Experimental Cancer Research, Malmö

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Cell and Molecular Biology

Keywords

  • Cancer metastasis, lipid kinaes, prostate cancer

Description

Existing metastatic disease represents a major clinical challenge. The long-term goal of our study is to gain deeper understanding of cellular mechanisms underlying cancer metastasis. We focus on identification and validation of new predictive biomarkers and drug targets that are specifically for metastatic cancer. We recently focus on studying the role of lipid kinases in particular, phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5K1a) that is responsible for activation PI3K/AKT pathways in cancer cell survival and metastasis. Our study will provide new information to define the complexity of the molecular pathways in cancer metastasis and treatment response, and provide new strategies to improve personalized therapy.

Recent research outputs

Per Larsson, Azharuddin Sajid Syed Khaja, Julius Semenas, Tianyan Wang, Martuza Sarwar, Nishtman Dizeyi, Athanasios Simoulis, Andreas Hedblom, Sun Nyunt Wai, Niels Ødum & Jenny L. Persson, 2020 Mar 15, In: International Journal of Cancer. 146, 6, p. 1686-1699 14 p.

Research output: Contribution to journalArticle

Heather Johnson, Jinan Guo, Xuhui Zhang, Heqiu Zhang, Athanasios Simoulis, Alan H.B. Wu, Taolin Xia, Fei Li, Wanlong Tan, Allan Johnson, Nishtman Dizeyi, Per Anders Abrahamsson, Lukas Kenner, Xiaoyan Feng, Chang Zou, Kefeng Xiao, Jenny L. Persson & Lingwu Chen, 2020, In: BMC Medicine. 18, 1, 376.

Research output: Contribution to journalArticle

Jinan Guo, Dale Liu, Xuhui Zhang, Heather Johnson, Xiaoyan Feng, Heqiu Zhang, Alan H.B. Wu, Lingwu Chen, Jiequn Fang, Zhangang Xiao, Kefeng Xiao, Jenny L. Persson & Chang Zou, 2020, In: Frontiers in cell and developmental biology. 8, 597961.

Research output: Contribution to journalArticle

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