Experimental Epilepsy Group

Organisational unit: Research group

More filtering options
  1. 2020
  2. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor.

    Esbjörn Melin, 2020, Lund: Lund University, Faculty of Medicine. 100 p.

    Research output: ThesisDoctoral Thesis (compilation)

  3. Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons

    Valentina Di Maria, Marine Moindrot, Martin Ryde, Antonino Bono, Luis Quintino & Marco Ledri, 2020, In : Frontiers in Molecular Neuroscience. 13, 168.

    Research output: Contribution to journalArticle

  4. Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

    Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia & David Paul Drucker Woldbye, 2020, In : Frontiers in Molecular Neuroscience. 13, 232.

    Research output: Contribution to journalArticle

  5. 2019
  6. Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy

    Esbjörn Melin, Avtandil Nanobashvili, Una Avdic, Casper R. Gøtzsche, My Andersson, David P.D. Woldbye & Merab Kokaia, 2019 Dec 13, In : Molecular Therapy - Methods and Clinical Development. 15, p. 179-193 15 p.

    Research output: Contribution to journalArticle

  7. Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy

    Asla Pitkänen, David C. Henshall, J. Helen Cross, Renzo Guerrini, Sergiusz Jozwiak, Merab Kokaia, Michele Simonato, Sanjay Sisodiya & Janet Mifsud, 2019, In : Epilepsia.

    Research output: Contribution to journalArticle

  8. Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons

    Shashank Vasudevan, Janko Kajtez, Ada Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez-Serrano, Stephan S. Keller & Jenny Emnéus, 2019, In : Advanced Science. 6, 24, 1902011.

    Research output: Contribution to journalArticle

  9. Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy

    Giovanna Paolone, Chiara Falcicchia, Francesca Lovisari, Merab Kokaia, William J. Bell, Tracie Fradet, Mario Barbieri, Lars U. Wahlberg, Dwaine F. Emerich & Michele Simonato, 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 11, p. 2144-2156 13 p.

    Research output: Contribution to journalArticle

  10. Unilateral ex vivo gene therapy by GDNF in epileptic rats

    Avtandil Nanobashvili, Esbjörn Melin, Dwaine Emerich, Jens Tornøe, Michele Simonato, Lars Wahlberg & Merab Kokaia, 2019, In : Gene Therapy. 26, 3-4, p. 65-74

    Research output: Contribution to journalArticle

  11. 2018
  12. Spatiotemporal pattern of Wnt-canonical pathway in dorsal telencephalic organoids.

    Ana Gonzalez Ramos, Jonothon Marshall & John O. Mason, 2018 Jul 6, (Unpublished).

    Research output: Contribution to conferencePoster

  13. Bridging the gap in translational epilepsy research - A patient brain tissue platform for validating animal data

    Jenny Wickham, 2018, Lund: Lund University: Faculty of Medicine. 79 p.

    Research output: ThesisDoctoral Thesis (compilation)

  14. 2017
  15. Altered chloride homeostasis decreases the action potential threshold and increases hyperexcitability in hippocampal neurons

    Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson & Merab Kokaia, 2017 Nov 1, In : eNeuro. 4, 6, e0172-17.2017.

    Research output: Contribution to journalArticle

  16. Epilepsy and optogenetics: Can seizures be controlled by light?

    Jan Tönnesen & Merab Kokaia, 2017 Jul 15, In : Clinical Science. 131, 14, p. 1605-1616 12 p.

    Research output: Contribution to journalReview article

  17. 2016
  18. DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue

    N. Avaliani, M. Andersson, A. H. Runegaard, D. Woldbye & M. Kokaia, 2016 Oct 1, In : Gene Therapy. 23, 10, p. 760-766 7 p.

    Research output: Contribution to journalArticle

  19. Advances in the development of biomarkers for epilepsy

    Asla Pitkänen, Wolfgang Löscher, Annamaria Vezzani, Albert J. Becker, Michele Simonato, Katarzyna Lukasiuk, Olli Gröhn, Jens P. Bankstahl, Alon Friedman, Eleonora Aronica, Jan A. Gorter, Teresa Ravizza, Sanjay M. Sisodiya, Merab Kokaia & Heinz Beck, 2016 Jul 1, In : Lancet Neurology. 15, 8, p. 843-856 14 p.

    Research output: Contribution to journalReview article

  20. Optogenetic control of human neurons in organotypic brain cultures

    My Andersson, Natalia Avaliani, Andreas Svensson, Jenny Wickham, Lars H. Pinborg, Bo Jespersen, Søren H. Christiansen, Johan Bengzon, David P D Woldbye & Merab Kokaia, 2016 Apr 21, In : Scientific Reports. 6, 24818.

    Research output: Contribution to journalArticle

  21. Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry

    Fredrik Berglind, 2016, Experimental Epilepsy Group. 71 p.

    Research output: ThesisDoctoral Thesis (compilation)

  22. Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors.

    Litsa Nikitidou, Esbjörn Melin, Søren H Christiansen, Casper R Gøtzsche, Alessandra Cifra, David P D Woldbye & Merab Kokaia, 2016, In : Neurobiology of Disease. 86, nov 19, p. 52-61

    Research output: Contribution to journalArticle

  23. 2015
  24. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    Natalia Avaliani, 2015, Department of Clinical Sciences, Lund University. 75 p.

    Research output: ThesisDoctoral Thesis (compilation)

  25. Differential Effect of Neuropeptides on Excitatory Synaptic Transmission in Human Epileptic Hippocampus.

    Marco Ledri, Andreas T Sørensen, Marita Grönning Madsen, Søren H Christiansen, Litsa Nikitidou Ledri, Alessandra Cifra, Johan Bengzon, Eva Lindberg, Lars H Pinborg, Bo Jespersen, Casper R Gøtzsche, David P D Woldbye, My Andersson & Merab Kokaia, 2015, In : Journal of Neuroscience. 35, 26, p. 9622-9631

    Research output: Contribution to journalArticle

  26. 2014
  27. A compact multifunctional microfluidic platform for exploring cellular dynamics in real-time using electrochemical detection

    K. Zor, A. Heiskanen, C. Caviglia, M. Vergani, E. Landini, F. Shah, M. Carminati, A. Martinez-Serrano, Tania Ramos Moreno, Merab Kokaia, D. Benayahu, Zs. Keresztes, D. Papkovsky, U. Wollenberger, W. E. Svendsen, M. Dimaki, G. Ferrari, R. Raiteri, M. Sampietro, M. Dufva & 1 others, J. Emneus, 2014, In : RSC Advances. 4, 109, p. 63761-63771

    Research output: Contribution to journalArticle

  28. Global Optogenetic Activation of Inhibitory Interneurons during Epileptiform Activity.

    Marco Ledri, Marita Grönning Madsen, Litsa Nikitidou, Deniz Kirik & Merab Kokaia, 2014, In : Journal of Neuroscience. 34, 9, p. 3364-3377

    Research output: Contribution to journalArticle

  29. How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

    Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz & Merab Kokaia, 2014, Issues in Clinical Epileptology: A View From the Bench. Scharfman, H. E. & Buckmaster, P. S. (eds.). Springer, Vol. 813. p. 319-336 (Advances in Experimental Medicine and Biology; vol. 813).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  30. Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

    Fredrik Berglind, Marco Ledri, Andreas Toft Sørensen, Litsa Nikitidou, Miriam Melis, Pascal Bielefeld, Deniz Kirik, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, In : Neurobiology of Disease. 65, p. 133-141

    Research output: Contribution to journalArticle

  31. Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors.

    Natalia Avaliani, Andreas Toft Sörensen, Marco Ledri, Johan Bengzon, Philipp Koch, Oliver Brüstle, Karl Deisseroth, My Andersson & Merab Kokaia, 2014, In : Stem Cells. 32, 12, p. 3088-3098

    Research output: Contribution to journalArticle

  32. 2013
  33. Epilepsy therapy development: Technical and methodologic issues in studies with animal models

    Aristea S. Galanopoulou, Merab Kokaia, Jeffrey A. Loeb, Astrid Nehlig, Asla Pitkanen, Michael A. Rogawski, Kevin J. Staley, Vicky H. Whittemore & F. Edward Dudek, 2013, In : Epilepsia. 54, p. 13-23

    Research output: Contribution to journalArticle

  34. 2012
  35. Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations.

    Marco Ledri, Litsa Nikitidou, Ferenc Erdelyi, Gabor Szabo, Deniz Kirik, Karl Deisseroth & Merab Kokaia, 2012, In : European Journal of Neuroscience. 36, 1, p. 1971-1983

    Research output: Contribution to journalArticle

  36. Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

    Casper R. Gotzsche, Litsa Nikitidou, Andreas Toft Sörensen, Mikkel V. Olesen, Gunnar Sorensen, Soren H. O. Christiansen, Mikael Ängehagen, David P. D. Woldbye & Merab Kokaia, 2012, In : Neurobiology of Disease. 45, 1, p. 288-296

    Research output: Contribution to journalArticle

  37. VEGF receptor-2 (flk-1) overexpression in mice counteracts focal epileptic seizures.

    Litsa Nikitidou, Irene Kanter Schlifke, Joke Dhondt, Peter Carmeliet, Diether Lambrechts & Merab Kokaia, 2012, In : PLoS ONE. 7, 7, e40535.

    Research output: Contribution to journalArticle

  38. 2011
  39. Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model.

    Jan Tønnesen, Clare L Parish, Andreas Toft Sörensen, Angelica Andersson, Cecilia Lundberg, Karl Deisseroth, Ernest Arenas, Olle Lindvall & Merab Kokaia, 2011, In : PLoS ONE. 6, 3, e17560.

    Research output: Contribution to journalArticle

  40. Tuning afferent synapses of hippocampal interneurons by neuropeptide Y.

    Marco Ledri, Andreas Toft Sörensen, Ferenc Erdelyi, Gabor Szabo & Merab Kokaia, 2011, In : Hippocampus. 21, p. 198-211

    Research output: Contribution to journalArticle

  41. 2010
  42. Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.

    David P D Woldbye, Mikael Ängehagen, Casper R Gøtzsche, Heidi Elbrønd-Bek, Andreas Toft Sörensen, Søren H Christiansen, Mikkel V Olesen, Litsa Nikitidou, Thomas V O Hansen, Irene Kanter Schlifke & Merab Kokaia, 2010, In : Brain. 133, Pt 9, p. 2778-2788

    Research output: Contribution to journalArticle

  43. 2009
  44. Optogenetic control of epileptiform activity.

    Jan Tønnesen, Andreas Toft Sörensen, Karl Deisseroth, Cecilia Lundberg & Merab Kokaia, 2009, In : Proceedings of the National Academy of Sciences. 106, 29, p. 12162-12167

    Research output: Contribution to journalArticle

  45. 2008
  46. Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in subiculum

    Andreas Toft Sörensen, Irene Kanter Schlifke, En-Ju D. Lin, Matthew J. During & Merab Kokaia, 2008, In : Molecular and Cellular Neuroscience. 39, 2, p. 229-37

    Research output: Contribution to journalArticle

  47. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    Andreas Toft Sörensen, 2008, Institutionen för kliniska vetenskaper, Lunds universitet. 134 p.

    Research output: ThesisDoctoral Thesis (compilation)

  48. 2007
  49. Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat.

    Irene Kanter Schlifke, Biljana Georgievska, Deniz Kirik & Merab Kokaia, 2007, In : NeuroReport. 18, 9, p. 845-850

    Research output: Contribution to journalArticle

  50. Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy.

    Irene Kanter Schlifke, Biljana Georgievska, Deniz Kirik & Merab Kokaia, 2007, In : Molecular Therapy. 15, p. 1106-1113

    Research output: Contribution to journalArticle

  51. 1989
  52. Ethanol stimulates basal and serotonin-induced formation of [32P]phosphatidic acid in human platelets

    Per Simonsson, Istvan Ferencz & Christer Alling, 1989, In : Drug and Alcohol Dependence. 24, 2, p. 169-174

    Research output: Contribution to journalArticle