Experimental oncology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Cancer and Oncology

Keywords

  • Tumor microenvironment , Targeted therapy, Angiogenesis, Cancer-associated fibroblasts, Mouse models of cancer

Description

Research

Our aim is to molecularly map support functions performed by the various cell types comprising the tumor microenvironment. We believe that decisive treatment benefit can only be achieved by targeting several of the cell types that collectively sustain tumor growth. Importantly, the cellular networks within tumors cannot be studied in isolation. Thus, our work ranges over many different topics, with methodology and purpose as common denominators: 1. Basic Biology Identification of new cellular subsets of the tumor stroma and their influence on cancer progression 2. Pre-clinical studies Investigation of the therapeutic utility of the tumor stroma 3. Translational studies Exploration of the tumor stroma as biomarkers of prognosis or response to therapy The overarching aim of our work is to generate basic knowledge about the interdependent way cells within a tumor relate to each other, as well as produce information that will be immediately useful for the design of clinical practice.

Recent research outputs

Phung, B., Cieśla, M., Sanna, A., Guzzi, N., Beneventi, G., Cao Thi Ngoc, P., Lauss, M., Cabrita, R., Cordero, E., Bosch, A., Rosengren, F., Häkkinen, J., Griewank, K., Paschen, A., Harbst, K., Olsson, H., Ingvar, C., Carneiro, A., Tsao, H., Schadendorf, D. & 3 othersKristian Pietras, Cristian Bellodi & Göran Jönsson, 2019 Jun 18, In : Cell Reports. 27, 12, p. 3573-3586.e7

Research output: Contribution to journalArticle

Strell, C., Paulsson, J., Jin, S-B., Tobin, N. P., Mezheyeuski, A., Roswall, P., Mutgan, C., Mitsios, N., Johansson, H., Wickberg, S. M., Svedlund, J., Nilsson, M., Hall, P., Mulder, J., Radisky, D. C., Kristian Pietras, Bergh, J., Lendahl, U., Wärnberg, F. & Östman, A., 2019 Feb 28, In : Journal of the National Cancer Institute.

Research output: Contribution to journalArticle

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