Experimental Pathology, Malmö

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Immunology in the medical area
  • Cell and Molecular Biology


  • WNT5A, melanoma, Breast cancer


Our studies are focused on the revelation of WNT5A, a secreted glycoprotein. WNT5A belongs to the non-transforming class of WNTs, and upon binding to different receptors or co-receptor complexes, it elicits non-canonical (ß-catenin-independent) signaling. WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. For example, in breast cancer loss of WNT5A protein is associated with poor survival. In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients. Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. On therapeutic front, we have developed a hexapeptide, Foxy5 (an agonist of WNT5A) which is in clinical trial for breast cancer, prostate cancer and colon carcinoma (NCT02020291). Another peptide, Box5 (a WNT5A derived antagonist) is in pre-clinical trials for malignant melanoma.


Recent research outputs

Njainday Pulo Jobe, Lisa Åsberg & Tommy Andersson, 2021 May 9, In: Molecular Oncology.

Research output: Contribution to journalArticle

Vikas Yadav, 2019 Sep 30, Germany: Scholars Press GMBH. 80 p.

Research output: Book/ReportBook

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