Genetic and Molecular Epidemiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics
  • Medical Genetics
  • Cell and Molecular Biology

Keywords

  • Genomics, epidemiology, Type 2 diabetes

Description

Unhealthful lifestyles underpin much of the burden of cardiometabolic disease affecting contemporary societies. Our overarching objective is to discover and optimise measurable biomarkers that can be used to stratify patient populations into subgroups that can be treated more effectively with targeted lifestyle therapies, at lesser cost and with fewer adverse events than conventional approaches allow. There are three integrated components to my research programme: 1.Epidemiology - observational studies 2.Functional genomics - ex vivo experiments 3.Randomized controlled trials - lifestyle intervention studies The tailoring of such therapies will, it is hoped, improve treatment effectiveness, reduce costs and unnecessary side effects, and improve patient adherence.

Recent research outputs

Carole H. Sudre, Benjamin Murray, Thomas Varsavsky, Mark S. Graham, Rose S. Penfold, Ruth C. Bowyer, Joan Capdevila Pujol, Kerstin Klaser, Michela Antonelli, Liane S. Canas, Erika Molteni, Marc Modat, M. Jorge Cardoso, Anna May, Sajaysurya Ganesh, Richard Davies, Long H. Nguyen, David A. Drew, Christina M. Astley, Amit D. Joshi & 13 others, Jordi Merino, Neli Tsereteli, Tove Fall, Maria F. Gomez, Emma L. Duncan, Cristina Menni, Frances M.K. Williams, Paul W. Franks, Andrew T. Chan, Jonathan Wolf, Sebastien Ourselin, Tim Spector & Claire J. Steves, 2021 Apr 1, In: Nature Medicine. 27, 4, p. 626–631 6 p.

Research output: Contribution to journalArticle

Patrick Wyatt, Sarah E. Berry, Graham Finlayson, Ruairi O’Driscoll, George Hadjigeorgiou, David A. Drew, Haya Al Khatib, Long H. Nguyen, Inbar Linenberg, Andrew T. Chan, Tim D. Spector, Paul W. Franks, Jonathan Wolf, John Blundell & Ana M. Valdes, 2021 Apr 1, In: Nature Metabolism. 3, 4, p. 523–529 7 p.

Research output: Contribution to journalArticle

Amra Jujić, Peter M Nilsson, Naeimeh Atabaki-Pasdar, Anna Dieden, Tiinamaija Tuomi, Paul W Franks, Jens Juul Holst, Signe Sørensen Torekov, Susana Ravassa, Javier Díez, Margaretha Persson, Emma Ahlqvist, Olle Melander, Maria F Gomez, Leif Groop & Martin Magnusson, 2021 Jan, In: Diabetes Care. 44, 1, p. 224-230 7 p.

Research output: Contribution to journalArticle

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