Hematogenomics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Immunology in the medical area
  • Immunology
  • Bioinformatics (Computational Biology)
  • Medical Genetics
  • Hematology
  • Cell and Molecular Biology
  • Clinical Laboratory Medicine

Keywords

  • Multiple myeloma, leukemia, ALL, AML, CRISPR/Cas9, shRNA, Flow cytometry, blood cell formation, population genetics, hematology, genomics, computional biology, bioinformatics

Description

Research

Our research group combines mathematics and genomics to address clinically important problems in hematology and immunology. Current projects focus on blood cell formation and blood disorders, e.g. multiple myeloma and childhood leukemia. The team of computer scientists, clinicians, and molecular biologists work closely together. Computational models are combined with genetic approaches to identify risk genes for blood- and immunological disorders, as well as regulators of the cell functions. Our network of international collaborations include deCODE Genetics and the Broad Institute. Our research has contributed to the understanding of inherited susceptibility to multiple myeloma, the identification of the gene behind the Vel-blood group and a diagnostic tool for the blood group used in clinical practice. Sources of funding include e.g. the Swedish foundation for Strategic Research, the Knut and Alice Wallenberg Foundation, The Swedish Childhood Cancer Foundation and Swedish Research Council.

Recent research outputs

Maroulio Pertesi, Björn Nilsson, McKay, J. D., Dumontet, C. & et al., 2019, In : Leukemia.

Research output: Contribution to journalLetter

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