Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Cell and Molecular Biology
- Immunology in the medical area
- Cancer and Oncology
Inflammation can be induced both by tissue damage and infection and the purpose of this physiological response is to repair damaged tissue and return it to normalcy. Inflammation is also a central component of both autoimmune disease and cancer. During such conditions, however, the inflammatory response is not properly regulated and the response becomes chronic and a component of disease. The sterile inflammation induced upon tissue injury has been shown to be due to be partially caused by the release of components from damaged and dying cells. These so-called DAMP (damage associated molecular patterns) molecules have been shown to be ligands of pro-inflammatory receptors such as TLRs and RAGE.
Recent research outputs
Pharmacologic exhaustion of suppressor cells with tasquinimod enhances bacterial clearance during tuberculosisGupta, S., Krug, S., Pokkali, S., Tomas Leanderson, Isaacs, J. T., Srikrishna, G. & Bishai, W. R., 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 3, p. 386-389 4 p.
Research output: Contribution to journal › Letter
The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosisFransén Pettersson, N., Deronic, A., Julia Nilsson, Hannibal, T., Hansen, L., Anja Schmidt-Christensen, Fredrik Ivars & Dan Holmberg, 2018 Sep 5, In : PLoS ONE. 13, 9, e0203228.
Research output: Contribution to journal › Article
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