Immunology

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  1. 2019
  2. Pharmacologic exhaustion of suppressor cells with tasquinimod enhances bacterial clearance during tuberculosis

    Gupta, S., Krug, S., Pokkali, S., Tomas Leanderson, Isaacs, J. T., Srikrishna, G. & Bishai, W. R., 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 3, p. 386-389 4 p.

    Research output: Contribution to journalLetter

  3. 2018
  4. The immunomodulatory quinoline-3-carboxamide paquinimod reverses established fibrosis in a novel mouse model for liver fibrosis

    Fransén Pettersson, N., Deronic, A., Julia Nilsson, Hannibal, T., Hansen, L., Anja Schmidt-Christensen, Fredrik Ivars & Dan Holmberg, 2018 Sep 5, In : PLoS ONE. 13, 9, e0203228.

    Research output: Contribution to journalArticle

  5. Induction of S100A9 homodimer formation in vivo

    Eva Källberg, Tahvili, S., Fredrik Ivars & Tomas Leanderson, 2018 Jun, In : Biochemical and Biophysical Research Communications. p. 564-568 5 p.

    Research output: Contribution to journalArticle

  6. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

    Vogl, T., Stratis, A., Wixler, V., Völler, T., Thurainayagam, S., Jorch, S. K., Zenker, S., Dreiling, A., Chakraborty, D., Fröhling, M., Paruzel, P., Wehmeyer, C., Hermann, S., Papantonopoulou, O., Geyer, C., Loser, K., Schäfers, M., Ludwig, S., Stoll, M., Leanderson, T. & 4 othersSchultze, J. L., König, S., Pap, T. & Roth, J., 2018 May 1, In : Journal of Clinical Investigation. 128, 5, p. 1852-1866 15 p.

    Research output: Contribution to journalArticle

  7. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse

    Tahvili, S., Törngren, M., Dan Holmberg, Tomas Leanderson & Fredrik Ivars, 2018 May 1, In : PLoS ONE. 13, 5, e0196598.

    Research output: Contribution to journalArticle

  8. Immunity to gastrointestinal nematode infections

    Sorobetea, D., Svensson-Frej, M. & Grencis, R., 2018 Mar 1, In : Mucosal Immunology. 11, 2, p. 304-315 12 p.

    Research output: Contribution to journalReview article

  9. Streptococcal M protein promotes IL-10 production by cGAS-independent activation of the STING signaling pathway

    Elin Movert, Julia Lienard, Valfridsson, C., Nordström, T., Bengt Johansson-Lindbom & Fredric Carlsson, 2018 Mar 1, In : PLoS Pathogens. 14, 3, e1006969.

    Research output: Contribution to journalArticle

  10. S100A9 in inflammatory disease: a potential target for amelioration

    Tahvili, S., 2018, Lund: Lund University, Faculty of Medicine. 72 p.

    Research output: ThesisDoctoral Thesis (compilation)

  11. 2017
  12. 2016
  13. IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.

    Oruc, Z., Oblet, C., Boumediene, A., Druilhe, A., Pascal, V., Le Rumeur, E., Cuvillier, A., El Hamel, C., Lecardeur, S., Tomas Leanderson, Morelle, W., Demengeot, J., Aldigier, J-C. & Cogné, M., 2016 Sep, In : Journal of the American Society of Nephrology : JASN. 27, 9, p. 2748-2761

    Research output: Contribution to journalArticle

  14. MLH1 Ile219Val polymorphism in argentinean families with suspected lynch syndrome

    Dominguez-Valentin, M., Wernhoff, P., Cajal, A. R., Kalfayan, P. G., Piñero, T. A., Gonzalez, M. L., Ferro, A., Sammartino, I., Causada Calo, N. S. & Vaccaro, C. A., 2016 Aug 24, In : Frontiers in Oncology. 6, AUG, 189.

    Research output: Contribution to journalArticle

  15. A reduced population of CD103+CD11b+ dendritic cells has a limited impact on oral Salmonella infection

    Fernández-Santoscoy, M., Wenzel, U. A., Persson, E., Yrlid, U., William Agace & Wick, M. J., 2016 Aug 1, In : Immunology Letters. 176, p. 72-80 9 p.

    Research output: Contribution to journalArticle

  16. A new mouse model that spontaneously develops chronic liver inflammation and fibrosis

    Fransén-Pettersson, N., Duarte, N., Julia Nilsson, Lundholm, M., Mayans, S., Larefalk, Å., Hannibal, T. D., Hansen, L., Anja Schmidt-Christensen, Fredrik Ivars, Cardell, S., Palmqvist, R., Rozell, B. & Dan Holmberg, 2016 Jul 1, In : PLoS ONE. 11, 7, e0159850.

    Research output: Contribution to journalArticle

  17. Eosinophils may play regionally disparate roles in influencing IgA+ plasma cell numbers during large and small intestinal inflammation

    Forman, R., Bramhall, M., Logunova, L., Svensson-Frej, M., Cruickshank, S. M. & Else, K. J., 2016 May 31, In : BMC Immunology. 17, 1, 12.

    Research output: Contribution to journalArticle

  18. CD14 is a co-receptor for TLR4 in the S100A9-induced pro-inflammatory response in monocytes

    He, Z., Riva, M., Björk, P., Karl Swärd, Mörgelin, M., Tomas Leanderson & Fredrik Ivars, 2016, In : PLoS ONE. 11, 5, e0156377.

    Research output: Contribution to journalArticle

  19. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis

    Stenström, M., Nyhlén, H. C., Törngren, M., Liberg, D., Sparre, B., Tuvesson, H., Eriksson, H. & Tomas Leanderson, 2016, In : Journal of Dermatological Science. 83, 1, p. 52-59 8 p.

    Research output: Contribution to journalArticle

  20. S100A9 in inflammation

    He, Z., 2016, Lund: Lund University, Faculty of Medicine. 62 p.

    Research output: ThesisDoctoral Thesis (compilation)

  21. Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.

    Rutardottir, S., Karnaukhova, E., Nantasenamat, C., Songtawee, N., Prachayasittikul, V., Rajabi, M., Wester Rosenlöf, L., Alayash, A. I. & Bo Åkerström, 2016, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 1, p. 29-41

    Research output: Contribution to journalArticle

  22. 2015
  23. Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells.

    Chakraborty, P., Bjork, P., Eva Källberg, Olsson, A., Riva, M., Mörgelin, M., Liberg, D., Fredrik Ivars & Tomas Leanderson, 2015 Dec, In : PLoS ONE. 10, 12, e0145217.

    Research output: Contribution to journalArticle

  24. A1M Ameliorates Preeclampsia-Like Symptoms in Placenta and Kidney Induced by Cell-Free Fetal Hemoglobin in Rabbit.

    Åsa Nääv, Lena Erlandsson, Axelsson, J., Larsson, I., Martin Johansson, Wester Rosenlöf, L., Mörgelin, M., Casslén, V., Magnus Gram, Bo Åkerström & Stefan Hansson, 2015, In : PLoS ONE. 10, 5, e0125499.

    Research output: Contribution to journalArticle

  25. Antagonistic Human FcγRIIB (CD32B) Antibodies Have Anti-Tumor Activity and Overcome Resistance to Antibody Therapy In Vivo.

    Roghanian, A., Teige, I., Mårtensson, L., Cox, K. L., Kovacek, M., Ljungars, A., Mattson, J., Sundberg, A., Vaughan, A. T., Shah, V., Smyth, N. R., Sheth, B., Chan, H. T. C., Li, Z-C., Williams, E. L., Manfredi, G., Oldham, R. J., Mockridge, C. I., James, S. A., Dahal, L. N. & 12 othersHussain, K., Björn Nilsson, Verbeek, J. S., Gunnar Juliusson, Markus Hansson, Mats Jerkeman, Johnson, P. W. M., Davies, A., Beers, S. A., Glennie, M. J., Frendéus, B. & Cragg, M. S., 2015, In : Cancer Cell. 27, 4, p. 473-488

    Research output: Contribution to journalArticle

  26. A phase 1 dose-escalation study of antibody BI-505 in relapsed/refractory multiple myeloma.

    Markus Hansson, Gimsing, P., Badros, A. Z., Martinsson Niskanen, T., Nahi, H., Offner, F., Salomo, M., Sonesson, E., Mau-Sorensen, M., Stenberg, Y., Sundberg, A., Teige, I., van Droogenbroeck, J., Wichert, S., Zangari, M., Frendeus, B., Korsgren, M., Poelman, M. & Tricot, G., 2015, In : Clinical Cancer Research. 21, 12, p. 2730-2736

    Research output: Contribution to journalArticle

  27. Effect of quinoline-3-carboxamides on myeloid cells in inflammation and cancer

    Deronic, A., 2015, Immunology, Experimental Medical Science, Lund University. 90 p.

    Research output: ThesisDoctoral Thesis (compilation)

  28. Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

    Westman, J., Praveen Papareddy, Dahlgren, M., Chakrakodi, B., Norrby-Teglund, A., Emanuel Smeds, Adam Linder, Mörgelin, M., Bengt Johansson Lindbom, Arne Egesten & Heiko Herwald, 2015, In : PLoS Pathogens. 11, 12, e1005319.

    Research output: Contribution to journalArticle

  29. Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.

    Pruenster, M., Kurz, A. R. M., Chung, K-J., Cao-Ehlker, X., Bieber, S., Nussbaum, C. F., Bierschenk, S., Eggersmann, T. K., Rohwedder, I., Heinig, K., Immler, R., Moser, M., Koedel, U., Gran, S., McEver, R. P., Vestweber, D., Verschoor, A., Leanderson, T., Chavakis, T., Roth, J. & 2 othersVogl, T. & Sperandio, M., 2015, In : Nature Communications. 6, 6915.

    Research output: Contribution to journalArticle

  30. MyD88 Signaling Regulates Steady-State Migration of Intestinal CD103+ Dendritic Cells Independently of TNF-α and the Gut Microbiota.

    Hägerbrand, K., Westlund, J., Yrlid, U., William Agace & Bengt Johansson Lindbom, 2015, In : Journal of Immunology. 195, 6, p. 2888-2899

    Research output: Contribution to journalArticle

  31. Myeloid-related protein 14 promote inflammation and injury in meningitis.

    Wache, C., Klein, M., Ostergaard, C., Angele, B., Häcker, H., Pfister, H-W., Pruenster, M., Sperandio, M., Tomas Leanderson, Roth, J., Vogl, T. & Koedel, U., 2015, In : Journal of Infectious Diseases. 212, 2, p. 247-257

    Research output: Contribution to journalArticle

  32. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis.

    Schelbergen, R. F., Geven, E. J., van den Bosch, M. H. J., Eriksson, H., Tomas Leanderson, Vogl, T., Roth, J., van de Loo, F. A. J., Koenders, M. I., van der Kraan, P. M., van den Berg, W. B., Blom, A. B. & van Lent, P. L. E. M., 2015, In : Annals of the Rheumatic Diseases. 74, 12, p. 2254-2258

    Research output: Contribution to journalArticle

  33. Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models

    Shen, L., Sundstedt, A., Ciesielski, M., Miles, K. M., Celander, M., Adelaiye, R., Orillion, A., Ciamporcero, E., Ramakrishnan, S., Ellis, L., Fenstermaker, R., Abrams, S. I., Eriksson, H., Tomas Leanderson, Olsson, A. & Pili, R., 2015, In : Cancer immunology research. 3, 2, p. 136-148

    Research output: Contribution to journalArticle

  34. Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment.

    Olsson, A., Nakhlé, J., Sundstedt, A., Plas, P., Bauchet, A-L., Pierron, V., Bruetschy, L., Deronic, A., Törngren, M., Liberg, D., Schmidlin, F. & Tomas Leanderson, 2015, In : Journal for ImmunoTherapy of Cancer. 3, 53.

    Research output: Contribution to journalArticle

  35. 2014
  36. A1M/α1-Microglobulin Protects from Heme-Induced Placental and Renal Damage in a Pregnant Sheep Model of Preeclampsia.

    Wester Rosenlöf, L., Casslén, V., Axelsson, J., Edström, A., Magnus Gram, Holmqvist, M., Martin Johansson, Larsson, I., David Ley, Karel Marsal, Mörgelin, M., Rippe, B., Rutardottir, S., Shohani, B., Bo Åkerström & Stefan Hansson, 2014, In : PLoS ONE. 9, 1, e86353.

    Research output: Contribution to journalArticle

  37. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment.

    Isaacs, J. T., Dalrymple, S. L., Rosen, D. M., Hammers, H., Olsson, A. & Tomas Leanderson, 2014, In : Oncotarget. 5, 18, p. 8093-8106

    Research output: Contribution to journalArticle

  38. Characterization of heme binding to recombinant α1-microglobulin.

    Karnaukhova, E., Rutardottir, S., Rajabi, M., Wester Rosenlöf, L., Alayash, A. I. & Bo Åkerström, 2014, In : Frontiers in Physiology. 5, 465.

    Research output: Contribution to journalArticle

  39. High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome.

    Tidehag, V., Hammarsten, P., Egevad, L., Granfors, T., Stattin, P., Tomas Leanderson, Wikström, P., Josefsson, A., Hägglöf, C. & Bergh, A., 2014, In : European Journal of Cancer. 50, 10, p. 1829-1835

    Research output: Contribution to journalArticle

  40. Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency

    Burger, N. B., Stuurman, K. E., Kok, E., Konijn, T., Schooneman, D., Niederreither, K., Coles, M., William Agace, Christoffels, V. M., Mebius, R. E., van de Pavert, S. A. & Bekker, M. N., 2014, In : Prenatal Diagnosis. 34, 13, p. 1312-1319

    Research output: Contribution to journalArticle

  41. Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice.

    Khmaladze, I., Kelkka, T., Guerard, S., Wing, K., Pizzolla, A., Saxena, A., Lundqvist, K., Holmdahl, M., Kutty Selva, N. & Holmdahl, R., 2014, In : Proceedings of the National Academy of Sciences. 111, 35, p. E3669-E3678

    Research output: Contribution to journalArticle

  42. Somatic cells with a heavy mitochondrial DNA mutational load render iPS cells with distinct differentiation defects.

    Martin Wahlestedt, Ameur, A., Moraghebi, R., Norddahl, G., Sten, G., Niels-Bjarne Woods & David Bryder, 2014, In : Stem Cells. 32, 5, p. 1173-1182

    Research output: Contribution to journalArticle

  43. 2013
  44. A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo.

    Veitonmäki, N., Markus Hansson, Zhan, F., Sundberg, A., Löfstedt, T., Ljungars, A., Li, Z-C., Martinsson-Niskanen, T., Zeng, M., Yang, Y., Danielsson, L., Kovacek, M., Lundqvist, A., Mårtensson, L., Teige, I., Tricot, G. & Frendéus, B., 2013, In : Cancer Cell. 23, 4, p. 502-515

    Research output: Contribution to journalArticle

  45. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.

    Martin Wahlestedt, Norddahl, G., Sten, G., Amol Ugale, Micha Frisk, M-A., Mattsson, R., Tomas Deierborg, Mikael Sigvardsson & David Bryder, 2013, In : Blood. 121, 21, p. 4257-4264

    Research output: Contribution to journalArticle

  46. Common Interactions between S100A4 and S100A9 Defined by a Novel Chemical Probe.

    Per Björkman, Eva Källberg, Wellmar, U., Riva, M., Olsson, A., He, Z., Törngren, M., Liberg, D., Fredrik Ivars & Tomas Leanderson, 2013, In : PLoS ONE. 8, 5, e63012.

    Research output: Contribution to journalArticle

  47. Effect of the quinoline-3-carboxamide ABR-215757 during inflammation

    Helmersson, S., 2013, Immunology. 84 p.

    Research output: ThesisDoctoral Thesis (compilation)

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