IPSC Laboratory for CNS Disease Modeling

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology


Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. To this aim, we generate induced pluripotent stem cells (iPSC) from patients, which we utilize to understand cell autonomous and non-cell autonomous processes that lead to neuronal damage. By generating iPSCs from patients suffering familial and idiopathic forms of the diseases, we aim to elucidate causative mechanisms leading to neural cell dysfunction, and neurodegeneration. Our cutting-edge approach will allow for the identification of new molecular targets, which could be used for the development of new diagnostic tools for early diagnosis, as well as for the stratification and recruitment of patients for future clinical trials.

Recent research outputs

Bogetofte, H., Jensen, P., Ryding, M., Schmidt, S. I., Okarmus, J., Ritter, L., Worm, C. S., Hohnholt, M. C., Carla Azevedo, Laurent Roybon, Bak, L. K., Waagepetersen, H., Ryan, B. J., Wade-Martins, R., Larsen, M. R. & Meyer, M., 2019 Jul 5, In : Frontiers in Cellular Neuroscience. 13, 297.

Research output: Contribution to journalArticle

Ekaterina Savchenko, Teku, G. N., Antonio Boza-Serrano, Kaspar Russ, Berns, M., Tomas Deierborg, Lamas, N. J., Wichterle, H., Rothstein, J., Henderson, C. E., Mauno Vihinen & Laurent Roybon, 2019 Jul 3, In : Scientific Reports. 9, 1, 9610.

Research output: Contribution to journalArticle

View All (33)