IPSC Laboratory for CNS Disease Modeling

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology


Research in the laboratory attempts to define pathogenic cellular and molecular mechanisms involved in synucleiopathies, in particular Parkinson's disease and multiple system atrophy, and Alzheimer's disease. To this aim, we generate induced pluripotent stem cells (iPSC) from patients, which we utilize to understand cell autonomous and non-cell autonomous processes that lead to neuronal damage. By generating iPSCs from patients suffering familial and idiopathic forms of the diseases, we aim to elucidate causative mechanisms leading to neural cell dysfunction, and neurodegeneration. Our cutting-edge approach will allow for the identification of new molecular targets, which could be used for the development of new diagnostic tools for early diagnosis, as well as for the stratification and recruitment of patients for future clinical trials.

Recent research outputs

Siebzehnrübl, F. A., Raber, K. A., Urbach, Y. K., Schulze-Krebs, A., Canneva, F., Moceri, S., Habermeyer, J., Achoui, D., Gupta, B., Steindler, D. A., Stephan, M., Nguyen, H. P., Bonin, M., Riess, O., Bauer, A., Aigner, L., Couillard-Despres, S., Paucar, M. A., Svenningsson, P., Osmand, A. & 11 othersAndreew, A., Zabel, C., Weiss, A., Kuhn, R., Moussaoui, S., Blockx, I., Van der Linden, A., Rachel Y. Cheong, Laurent Roybon, Åsa Petersén & Von Hörsten, S., 2018 Sep 11, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8765-E8774

Research output: Contribution to journalArticle

Marote, A., Yuriy Pomeshchik, Collin, A., Goldwurm, S., Lamas, N. J., Pinto, L., Salgado, A. J. & Laurent Roybon, 2018 Apr 1, In : Stem Cell Research. 28, p. 44-47 4 p.

Research output: Contribution to journalArticle

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