Malaria and Babesia

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Microbiology in the medical area
  • Infectious Medicine
  • Clinical Laboratory Medicine

Description

Research

Both Malaria and Babesia are parasites that live inside red blood cells. Malaria is spread with mosquitoes while Babesia is spread with ticks. We are looking for the mechanism for how the parasites enter the red blood cells to be able to find better medications, but also to understand how immunity against these diseases is formed. For Malaria we have shown that some antibodies bind with high affinity to their target antigens, and they can also stop invasion of new red blood cells, while other antibodies not are that efficient. We have also created a new method to measure Plasmodium falciparum-specific atypical Memory B-cells, and shown that these cells are very common in malaria endemic areas. For Babesia we have recently in a study from Skåne shown that almost one fifth of those that had Borrelia also had Babesia. We are now doing a bigger study to try and answer the question of whether donated blood should be screened for Babesia, since it can also spread via blood transfusion.

Recent research outputs

Caroline Rönnberg, Allan Lugaajju, Anna Nyman, Ulf Hammar, Matteo Bottai, Maximilian Julius Lautenbach, Christopher Sundling, Fred Kironde & Kristina E.M. Persson, 2021 Jan, In: PLoS ONE. 16, 1 January, e0245431.

Research output: Contribution to journalArticle

Linda Reiling, Michelle J. Boyle, Michael T. White, Danny W. Wilson, Gaoqian Feng, Rupert Weaver, D. Herbert Opi, Kristina E.M. Persson, Jack S. Richards, Peter M. Siba, Freya J.I. Fowkes, Eizo Takashima, Takafumi Tsuboi, Ivo Mueller & James G. Beeson, 2019 Feb 5, In: Nature Communications. 10, 1, 610.

Research output: Contribution to journalArticle

Christopher Sundling, Caroline Rönnberg, Victor Yman, Muhammad Asghar, Peter Jahnmatz, Tadepally Lakshmikanth, Yang Chen, Jaromir Mikes, Mattias N. Forsell, Klara Sondén, Adnane Achour, Petter Brodin, Kristina E.M. Persson & Anna Färnert, 2019, In: JCI Insight. 4, 9, e126492.

Research output: Contribution to journalArticle

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