Medical Microspectroscopy

Organisational unit: Research group

Research

Ageing of the world’s population has amplified neurodegenerative disorders, of which Alzheimer’s disease (AD) and Parkinson’s disease (PD) are most common dementias. Both disorders are characterized by abnormal aggregation of proteins in brain. The molecular mechanism (or mechanisms) leading to the abnormal accumulation of ggregation of proteins remains unknown. We want to understand why abnormal protein aggregation begins and how these aggregated proteins (a-synuclein, amyloid-ß, and tau) may interact in vitro and in vivo combining advanced microscopy with synchrotron based micro- and nano-spectrocopic techniques.

Recent research outputs

Mustafa Kanziz, Alice Spadea, Jayakrupakar Nallala, Cassio Lima, Howbeer Muhamadali, Joanna Denbigh, Jayne Lawrence, Gorkem Bakir, Peter Gardner, Nick Stone, Roy Goodacre, Kathleen Gough & Oxana Klementieva, 2021 Mar 5, In: Advanced Chemical Microscopy for Life Science and Translational Medicine. 11656, 1165617.

Research output: Contribution to journalReview article

Oxana Klementieva, Christophe Sandt, Isak Martinsson, Mustafa Kansiz, Gunnar Keppler Gouras & Ferenc Borondics, 2020 Feb 7, In: Advanced Science. 9 p., 1903004.

Research output: Contribution to journalArticle

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