Melanoma Genomics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Research

Recently the treatment landscape of metastatic melanoma has changed dramatically with introduction of targeted therapy and novel immune checkpoint blockade agents. However, acquired resistance to targeted therapy and relatively low response rates to immune therapy poses a major problem. Thus, increased knowledge in melanoma biology and identification of novel therapeutic strategies is a necessity to further increase survival. We posit that using human tumor molecular data as a foundation for functional studies will lead us to novel insights about the fundamental biology of melanoma as well as provide us with inspiration for designing novel therapeutic strategies. Accordingly, our research program is focused on genomic tumor biology and the subsequent functional elucidation of biological mechanisms. We are also part of international melanoma consortia such as MELGEN (www.melgen.org) and GenoMEL (www.genomel.org).

Recent research outputs

Newell, F., Kong, Y., Wilmott, J. S., Johansson, P. A., Ferguson, P. M., Cui, C., Li, Z., Kazakoff, S. H., Burke, H., Dodds, T. J., Patch, A. M., Nones, K., Tembe, V., Shang, P., van der Weyden, L., Wong, K., Holmes, O., Lo, S., Leonard, C., Wood, S. & 24 othersXu, Q., Rawson, R. V., Mukhopadhyay, P., Dummer, R., Levesque, M. P., Göran Jönsson, Wang, X., Yeh, I., Wu, H., Joseph, N., Bastian, B. C., Long, G. V., Spillane, A. J., Shannon, K. F., Thompson, J. F., Saw, R. P. M., Adams, D. J., Si, L., Pearson, J. V., Hayward, N. K., Waddell, N., Mann, G. J., Guo, J. & Scolyer, R. A., 2019 Jul 18, In : Nature Communications. 10, 1, 3163.

Research output: Contribution to journalArticle

Nathan, V., Johansson, P. A., Palmer, J. M., Howlie, M., Hamilton, H. R., Wadt, K., Göran Jönsson, Brooks, K. M., Pritchard, A. L. & Hayward, N. K., 2019 Jun 24, In : Pigment Cell and Melanoma Research.

Research output: Contribution to journalArticle

Phung, B., Cieśla, M., Sanna, A., Guzzi, N., Beneventi, G., Cao Thi Ngoc, P., Lauss, M., Cabrita, R., Cordero, E., Bosch, A., Rosengren, F., Häkkinen, J., Griewank, K., Paschen, A., Harbst, K., Olsson, H., Ingvar, C., Carneiro, A., Tsao, H., Schadendorf, D. & 3 othersKristian Pietras, Cristian Bellodi & Göran Jönsson, 2019 Jun 18, In : Cell Reports. 27, 12, p. 3573-3586.e7

Research output: Contribution to journalArticle

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