Molecular Neurobiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Neurosciences
  • Cell and Molecular Biology


A common feature of multiple neurodegenerative diseases is the formation large protein rich aggregates inside neurons. Accumulating evidence suggests that the build-up of these large aggregates, may be driven primarily by misfolded amyloid proteins. Our focus is to investigate how chaperones involved in regulation of protein folding and protein homeostasis, might suppress aggregation of amyloid proteins such as alpha-synuclein, ,tau and huntingtin. We are particularly interested in a class of HSP70 co-chaperones named DNAJ proteins. Mutations in several DNAJ genes are genetically linked to an increased risk of contracting Parkinson’s Disease, but very little is known about the molecular mechanisms behind this. Our research group uses a variety of molecular biology tools, cell culture models and rodent models to pinpoint how these DNAJ proteins may suppress protein aggregation and be neuroprotective in Parkinson’s Disease and other neurodegenerative diseases.

Recent research outputs

Eduardo P. De Mattos, Anne Wentink, Carmen Nussbaum-Krammer, Christian Hansen, Steven Bergink, Ronald Melki & Harm H. Kampinga, 2020 Apr 3, In: Journal of Parkinson's Disease. 10, 2, p. 369-382 14 p.

Research output: Contribution to journalReview article

Claudio Rodríguez-González, Shiying Lin, Sertan Arkan & Christian Hansen, 2020, In: Scientific Reports. 10, 1, 8130.

Research output: Contribution to journalArticle

Natasja Deshayes, Sertan Arkan & Christian Hansen, 2019 Sep 11, In: International Journal of Molecular Sciences. 20, 18, 4495.

Research output: Contribution to journalArticle

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