Molecular Neuromodulation

Organisational unit: Research group

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  1. 2020
  2. Deep learning-enhanced light-field imaging with continuous validation

    Wagner, N., Beuttenmueller, F., Nils Norlin, Gierten, J., Wittbrodt, J., Weigert, M., Hufnagel, L., Prevedel, R. & Kreshuk, A., 2020 Jul 31, In : bioRxiv. 24 p., 2020.07.30.228924.

    Research output: Contribution to journalArticle

  3. 2019
  4. Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

    Carl Rosenblad, Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S. L. M., Agúndez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Anders Björklund, Bezard, E. & Tomas Björklund, 2019, In : Brain : a journal of neurology. p. 2402-2416

    Research output: Contribution to journalArticle

  5. 2018
  6. A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

    Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R. J., Parker, H., Liao, A. Y., Rouse, P., Youshani, A. S., Dridi, L., Martins, C., Levade, T., Stacey, K. B., Davis, D. M. & 11 others, Dyer, A., Clément, N., Tomas Björklund, Ali, R. R., Agbandje-McKenna, M., Rahim, A. A., Pshezhetsky, A., Waddington, S. N., Linden, R. M., Bigger, B. W. & Henckaerts, E., 2018 Jul 1, In : Brain. 141, 7, p. 2014-2031 18 p.

    Research output: Contribution to journalArticle

  7. Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

    Marcus Davidsson, Díaz-Fernández, P., Torroba, M., Schwich, O. D., Patrick Aldrin-Kirk, Luis Quintino, Andreas Heuer, Wang, G., Cecilia Lundberg & Tomas Björklund, 2018 May 1, In : RNA. 24, 5, p. 673-687 15 p.

    Research output: Contribution to journalArticle

  8. Automated Operant Assessments of Huntington's Disease Mouse Models

    Yhnell, E. & Andreas Heuer, 2018, In : Methods in molecular biology (Clifton, N.J.). 1780, p. 143-162 20 p.

    Research output: Contribution to journalArticle

  9. Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain

    Luis Quintino, Namislo, A., Marcus Davidsson, Breger, L. S., Kavanagh, P., Martino Avallone, Elgstrand-Wettergren, E., Isaksson, C. & Cecilia Lundberg, 2018, In : Molecular Therapy - Methods and Clinical Development. 11, p. 29-39 11 p.

    Research output: Contribution to journalArticle

  10. Repairing the brain: Gene therapy

    Tomas Björklund, 2018, In : Journal of Parkinson's Disease. 8, s1, p. S123-S130

    Research output: Contribution to journalReview article

  11. 2017
  12. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus

    Avaliani, N., Pfisterer, U., Andreas Heuer, Malin Parmar, Merab Kokaia & My Andersson, 2017 Nov 26, In : Stem Cells International. 2017, 9 p., 5718608.

    Research output: Contribution to journalArticle

  13. 2016
  14. A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

    Marcus Davidsson, Diaz-Fernandez, P., Schwich, O. D., Torroba, M., Wang, G. & Tomas Björklund, 2016 Nov 22, In : Scientific Reports. 6, 37563.

    Research output: Contribution to journalArticle

  15. Identification of multiple QTLs linked to neuropathology in the engrailed-1 heterozygous mouse model of Parkinson's disease

    Kurowska, Z., Jewett, M., Brattås, P. L., Itzia Jimenez, Kenéz, X., Tomas Björklund, Nordström, U., Brundin, P. & Maria Swanberg, 2016 Aug 23, In : Scientific Reports. 6, 31701.

    Research output: Contribution to journalArticle

  16. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

    Patrick Aldrin-Kirk, Andreas Heuer, Wang, G., Mattsson, B., Lundblad, M., Malin Parmar & Tomas Björklund, 2016 Jun 1, In : Neuron. 90, 5, p. 955-968 14 p.

    Research output: Contribution to journalArticle

  17. Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

    Tomas Björklund, 2016, In : Methods in Molecular Biology. 1382, p. 41-56

    Research output: Contribution to journalArticle

  18. 2014
  19. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

    Holmqvist, S., Chutna, O., Bousset, L., Patrick Aldrin-Kirk, Wen Li, Tomas Björklund, Wang, Z-Y., Laurent Roybon, Melki, R. & Jia-Yi Li, 2014, In : Acta Neuropathologica. 128, 6, p. 805-820

    Research output: Contribution to journalArticle

  20. 2013
  21. A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

    Christian Hansen, Tomas Björklund, Petit, G., Lundblad, M., Murmu, R., Brundin, P. & Jia-Yi Li, 2013, In : Neurobiology of Disease. 56C, April,30, p. 145-155

    Research output: Contribution to journalArticle

  22. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

    Cederfjäll, E., Nilsson, N., Gurdal Sahin, Chu, Y., Nikitidou, E., Tomas Björklund, Kordower, J. H. & Deniz Kirik, 2013, In : Scientific Reports. 3, 2157.

    Research output: Contribution to journalArticle

  23. 2012
  24. 2011
  25. Gene therapy for Parkinson's disease shows promise.

    Anders Björklund & Tomas Björklund, 2011, In : Science Translational Medicine. 3, 79, p. 79ed1

    Research output: Contribution to journalArticle

  26. 2010
  27. Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

    Dodiya, H. B., Tomas Björklund, Stansell, J. III., Mandel, R. J., Deniz Kirik & Kordower, J. H., 2010, In : Molecular Therapy. 18, 3, p. 579-587

    Research output: Contribution to journalArticle

  28. Gene therapy for dopamine replacement.

    Tomas Björklund, Cederfjäll, E. & Deniz Kirik, 2010, In : Progress in Brain Research. 184, p. 221-235

    Research output: Contribution to journalReview article

  29. Gene therapy for Parkinson's disease.

    Tomas Björklund & Kordower, J. H., 2010, In : Movement Disorders. 25 Suppl 1, p. S161-S173

    Research output: Contribution to journalArticle

  30. 2009
  31. Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

    Tomas Björklund, Hall, H., Breysse, N., Soneson, C., Carlsson, T., Mandel, R. J., Carta, M. & Deniz Kirik, 2009, In : Journal of Neurochemistry. 111, 2, p. 355-367

    Research output: Contribution to journalArticle

  32. 2008
  33. Future Cell- and Gene-Based Therapies for Parkinson's Disease

    Tomas Björklund, Morizane, A., Deniz Kirik & Brundin, P., 2008, Therapeutics of Parkinson's Disease and Other Movement Disorders. Hallett, M. & Poewe, P. (eds.). John Wiley and Sons Inc., p. 145-156

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  34. 2007
  35. 2006
  36. Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

    Emdad, R., Bonekamp, D., Sondergaard, H. P., Tomas Björklund, Agartz, I., Ingvar, M. & Theorell, T., 2006, In : Psychotherapy and Psychosomatics. 75, 2, p. 122-132

    Research output: Contribution to journalLetter