Molecular Neuromodulation

Organisational unit: Research group

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  1. 2020
  2. Deep learning-enhanced light-field imaging with continuous validation

    Nils Wagner, Fynn Beuttenmueller, Nils Norlin, Jakob Gierten, Joachim Wittbrodt, Martin Weigert, Lars Hufnagel, Robert Prevedel & Anna Kreshuk, 2020 Jul 31, In : bioRxiv. 24 p., 2020.07.30.228924.

    Research output: Contribution to journalArticle

  3. 2019
  4. Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease

    Carl Rosenblad, Qin Li, Elsa Y Pioli, Sandra Dovero, André S L M Antunes, Leticia Agúndez, Martino Bardelli, R Michael Linden, Els Henckaerts, Anders Björklund, Erwan Bezard & Tomas Björklund, 2019, In : Brain : a journal of neurology. p. 2402-2416

    Research output: Contribution to journalArticle

  5. 2018
  6. A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency

    Julie Tordo, Claire O'Leary, André S.L.M. Antunes, Nuria Palomar, Patrick Aldrin-Kirk, Mark Basche, Antonette Bennett, Zelpha D'Souza, Hélène Gleitz, Annie Godwin, Rebecca J. Holley, Helen Parker, Ai Yin Liao, Paul Rouse, Amir Saam Youshani, Larbi Dridi, Carla Martins, Thierry Levade, Kevin B. Stacey, Daniel M. Davis & 11 others, Adam Dyer, Nathalie Clément, Tomas Björklund, Robin R. Ali, Mavis Agbandje-McKenna, Ahad A. Rahim, Alexey Pshezhetsky, Simon N. Waddington, R. Michael Linden, Brian W. Bigger & Els Henckaerts, 2018 Jul 1, In : Brain. 141, 7, p. 2014-2031 18 p.

    Research output: Contribution to journalArticle

  7. Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing

    Marcus Davidsson, Paula Díaz-Fernández, Marcos Torroba, Oliver D. Schwich, Patrick Aldrin-Kirk, Luis Quintino, Andreas Heuer, Gang Wang, Cecilia Lundberg & Tomas Björklund, 2018 May 1, In : RNA. 24, 5, p. 673-687 15 p.

    Research output: Contribution to journalArticle

  8. Automated Operant Assessments of Huntington's Disease Mouse Models

    Emma Yhnell & Andreas Heuer, 2018, In : Methods in molecular biology (Clifton, N.J.). 1780, p. 143-162 20 p.

    Research output: Contribution to journalArticle

  9. Destabilizing Domains Enable Long-Term and Inert Regulation of GDNF Expression in the Brain

    Luis Quintino, Angrit Namislo, Marcus Davidsson, Ludivine S. Breger, Patrick Kavanagh, Martino Avallone, Erika Elgstrand-Wettergren, Christina Isaksson & Cecilia Lundberg, 2018, In : Molecular Therapy - Methods and Clinical Development. 11, p. 29-39 11 p.

    Research output: Contribution to journalArticle

  10. Repairing the brain: Gene therapy

    Tomas Björklund, 2018, In : Journal of Parkinson's Disease. 8, s1, p. S123-S130

    Research output: Contribution to journalReview article

  11. 2017
  12. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus

    Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia & My Andersson, 2017 Nov 26, In : Stem Cells International. 2017, 9 p., 5718608.

    Research output: Contribution to journalArticle

  13. 2016
  14. A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

    Marcus Davidsson, Paula Diaz-Fernandez, Oliver D. Schwich, Marcos Torroba, Gang Wang & Tomas Björklund, 2016 Nov 22, In : Scientific Reports. 6, 37563.

    Research output: Contribution to journalArticle

  15. Identification of multiple QTLs linked to neuropathology in the engrailed-1 heterozygous mouse model of Parkinson's disease

    Zuzanna Kurowska, Michael Jewett, Per Ludvik Brattås, Itzia Jimenez, Xuyian Kenéz, Tomas Björklund, Ulrika Nordström, Patrik Brundin & Maria Swanberg, 2016 Aug 23, In : Scientific Reports. 6, 31701.

    Research output: Contribution to journalArticle

  16. DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

    Patrick Aldrin-Kirk, Andreas Heuer, Gang Wang, Bengt Mattsson, Martin Lundblad, Malin Parmar & Tomas Björklund, 2016 Jun 1, In : Neuron. 90, 5, p. 955-968 14 p.

    Research output: Contribution to journalArticle

  17. Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

    Tomas Björklund, 2016, In : Methods in Molecular Biology. 1382, p. 41-56

    Research output: Contribution to journalArticle

  18. 2014
  19. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

    Staffan Holmqvist, Oldriska Chutna, Luc Bousset, Patrick Aldrin-Kirk, Wen Li, Tomas Björklund, Zhan-You Wang, Laurent Roybon, Ronald Melki & Jia-Yi Li, 2014, In : Acta Neuropathologica. 128, 6, p. 805-820

    Research output: Contribution to journalArticle

  20. 2013
  21. A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

    Christian Hansen, Tomas Björklund, Géraldine Petit, Martin Lundblad, Reena Murmu, Patrik Brundin & Jia-Yi Li, 2013, In : Neurobiology of Disease. 56C, April,30, p. 145-155

    Research output: Contribution to journalArticle

  22. Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

    Erik Cederfjäll, Nathalie Nilsson, Gurdal Sahin, Yaping Chu, Elisabeth Nikitidou, Tomas Björklund, Jeffrey H Kordower & Deniz Kirik, 2013, In : Scientific Reports. 3, 2157.

    Research output: Contribution to journalArticle

  23. 2012
  24. 2011
  25. Gene therapy for Parkinson's disease shows promise.

    Anders Björklund & Tomas Björklund, 2011, In : Science Translational Medicine. 3, 79, p. 79ed1

    Research output: Contribution to journalArticle

  26. 2010
  27. Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

    Hemraj B. Dodiya, Tomas Björklund, James, III Stansell, Ronald J. Mandel, Deniz Kirik & Jeffrey H. Kordower, 2010, In : Molecular Therapy. 18, 3, p. 579-587

    Research output: Contribution to journalArticle

  28. Gene therapy for dopamine replacement.

    Tomas Björklund, Erik Cederfjäll & Deniz Kirik, 2010, In : Progress in Brain Research. 184, p. 221-235

    Research output: Contribution to journalReview article

  29. Gene therapy for Parkinson's disease.

    Tomas Björklund & Jeffrey H Kordower, 2010, In : Movement Disorders. 25 Suppl 1, p. S161-S173

    Research output: Contribution to journalArticle

  30. Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.

    Tomas Björklund, Thomas Carlsson, Erik Cederfjäll, Manolo Carta & Deniz Kirik, 2010, In : Brain. 133, Pt 2, p. 496-511

    Research output: Contribution to journalArticle

  31. 2009
  32. Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats

    Tomas Björklund, Helene Hall, Nathalie Breysse, Charlotte Soneson, Thomas Carlsson, Ronald J. Mandel, Manolo Carta & Deniz Kirik, 2009, In : Journal of Neurochemistry. 111, 2, p. 355-367

    Research output: Contribution to journalArticle

  33. 2008
  34. Future Cell- and Gene-Based Therapies for Parkinson's Disease

    Tomas Björklund, Asuka Morizane, Deniz Kirik & Patrik Brundin, 2008, Therapeutics of Parkinson's Disease and Other Movement Disorders. Hallett, M. & Poewe, P. (eds.). John Wiley and Sons Inc., p. 145-156

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  35. 2007
  36. 2006
  37. Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls

    Reza Emdad, David Bonekamp, Hans Peter Sondergaard, Tomas Björklund, Ingrid Agartz, Martin Ingvar & Tores Theorell, 2006, In : Psychotherapy and Psychosomatics. 75, 2, p. 122-132

    Research output: Contribution to journalLetter