Molecular Vascular Physiology

Organisational unit: Research group

Description

Both coding and non-coding (e.g. microRNAs) genes play a crucial role for the regulation of smooth muscle phenotype, which may have major implications for the progression of vascular disease. However, the genetic regulation of smooth muscle phenotype is just beginning to be understood and there is an immense potential for novel discoveries in the field. The general aim of our research is to identify new genes, both coding and non-coding, that are important for smooth muscle phenotype modulation in vascular disease.

Research

Our studies have identified a number of novel genes that are involved in the regulation of smooth muscle phenotype. In recent years, our research has been focused on the role of smooth muscle miRNAs in mechanosensing of smooth muscle. However, we are also investigating the importance of smooth muscle genes regulated by the actin cytoskeleton and hyperglycemia since we believe that these are two vital factors in the development of vascular disease. Cardiovascular disease is still the leading cause of death worldwide and novel treatment strategies are warranted. MicroRNAs represent a promising new class of drug targets against several disease states, including vascular disease.

Recent research outputs

Martina M De Santis, Hani N Alsafadi, Sinem Tas, Deniz A Bölükbas, Sujeethkumar Prithiviraj, Iran A Da Silva, Margareta Mittendorfer, Chiharu Ota, John Stegmayr, Fatima Daoud, Melanie Königshoff, Karl Swärd, Jeffery A Wood, Manlio Tassieri, Paul E Bourgine, Sandra Lindstedt, Sofie Mohlin & Darcy E Wagner, 2021, In: Advanced Materials. 33, 3, 2005476.

Research output: Contribution to journalArticle

Karl Swärd, Sebastian Albinsson & Catarina Rippe, 2021, Vascular Mechanobiology in Physiology and Disease. Springer Science + Business Media, p. 69-96 28 p. (Cardiac and Vascular Biology; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingBook chapter

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