Neurobiology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Neurosciences
  • Neurology

Description

Our research aims at developing new restorative and neuroprotective treatments for neurodegenerative diseases using cell transplantation and direct in vivo gene delivery. The Neurobiology Unit seeks to develop techniques for isolation and identification of neural progenitor cells with the capacity to generate fully functional dopamine neurons after transplantation to the Parkinsonian brain.

Research

We use cell sorting and cell engineering techniques to generate dopamine neuron precursor cells specifically for transplantation purposes, and explore techniques for insertion of genes into stem cells to direct the development of stem cells into transplantable midbrain dopamine neurons. In a second line of research we explore rodent models of Parkinson´s disease to study the mechanisms underlying development of L-DOPA-induced dyskinesias, and use recombinant viral vectors as tools to model Parkinson-like neurodegeneration in rodents, and for delivery of putative therapeutic factors, GDNF and Nurr 1 in particular, to the brain.

Recent research outputs

Meeter, L. H. H., Steketee, R. M. E., Salkovic, D., Vos, M. E., Grossman, M., McMillan, C. T., Irwin, D. J., Boxer, A. L., Rojas, J. C., Olney, N. T., Karydas, A., Miller, B. L., Pijnenburg, Y. A. L., Barkhof, F., Sánchez-Valle, R., Lladó, A., Borrego-Ecija, S., Diehl-Schmid, J., Grimmer, T., Goldhardt, O. & 27 othersAlexander F. Santillo, Oskar Hansson, Susanne Vestberg, Borroni, B., Padovani, A., Galimberti, D., Scarpini, E., Rohrer, J. D., Woollacott, I. O. C., Synofzik, M., Wilke, C., De Mendonca, A., Vandenberghe, R., Benussi, L., Ghidoni, R., Binetti, G., Niessen, W. J., Papma, J. M., Seelaar, H., Jiskoot, L. C., De Jong, F. J., Donker Kaat, L., Del Campo, M., Teunissen, C. E., Bron, E. E., Van Den Berg, E. & Van Swieten, J. C., 2019 May 28, In : Journal of Neurology, Neurosurgery and Psychiatry. 8 p.

Research output: Contribution to journalArticle

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