Orthopedics - Clinical and Molecular Osteoporosis Research
Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Medical Genetics
- Sport and Fitness Sciences
- Public Health, Global Health, Social Medicine and Epidemiology
- Osteoporosis, skeleton, muscle
Osteoporosis predominantly, but not exclusively affects older women and its clinical consequence, fracture, results in pain, lost independence and premature death. In our research we investigate the genetic and non-genetic factors contributing to skeletal strength in young adults, men and elderly women, with an emphasis on defining the genes, age related gene-environment interactions and interactions between the skeleton, muscle, adipose tissue, inflammation and metabolism. Our research strategy takes an integrated approach connecting basic science and clinical research through 1) Genetic studies in population based cohorts of young and elderly women with more than 10y of longitudinal data 2) Experimental studies in human bone tissue and animal models 3) Translational studies applying our research findings clinically at the Osteoporosis Research Unit, Malmö. Ultimately, our aim is to identify very high-risk individuals and personalize fracture prevention management.
Recent research outputs
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Severity of idiopathic scoliosis is associated with differential methylation: An epigenome‐wide association study of monozygotic twins with idiopathic scoliosisPatrick M. Carry, Elizabeth A. Terhune, George D. Trahan, Lauren A. Vanderlinden, Cambria I. Wethey, Parvaneh Ebrahimi, Fiona McGuigan, Kristina Åkesson & Nancy Hadley‐Miller, 2021 Aug, In: Genes. 12, 8, 1191.
Research output: Contribution to journal › Article