Pathways of cancer cell evolution

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Genetics
  • Cancer and Oncology
  • Pediatrics
  • Biomedical Laboratory Science/Technology

Keywords

  • Pathology, Paediatrics, Childhood cancer

Description

Research

We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. In particular, we aim to: 1. Make phylogenetic maps of cancer cell variation over anatomic space and treatment time in order to understand the conditions leading to treatment resistance; 2. Assess the functional effect on the RNA and protein levels of genetic variation in tumours; 3. Analyze to what extent clinical biomarkers exhibit variability within a tumour lineage – a potentially important source of error in clinical decision making; 4. Evaluate the potential of using parameters of genetic variation as biomarkers for response to treatment. To reach these aims we use a combination of traditional histopathology and next-generation sequencing technologies. We focus on three of the most common solid tumours in children: neuroblastoma, Wilms tumour and rhabdomyosarcoma.

Recent research outputs

Andersson, N., Bakker, B., Karlsson, J., Anders Valind, Linda Holmquist Mengelbier, Spierings, D. C. J., Foijer, F. & David Gisselsson, 2020 Apr, In : Cancer Research. 80, 7, p. 1512-1523 12 p.

Research output: Contribution to journalArticle

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