Pathways of cancer cell evolution

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Genetics
  • Cancer and Oncology
  • Pediatrics
  • Biomedical Laboratory Science/Technology

Keywords

  • Pathology, Paediatrics, Childhood cancer

Description

Research

We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. In particular, we aim to: 1. Make phylogenetic maps of cancer cell variation over anatomic space and treatment time in order to understand the conditions leading to treatment resistance; 2. Assess the functional effect on the RNA and protein levels of genetic variation in tumours; 3. Analyze to what extent clinical biomarkers exhibit variability within a tumour lineage – a potentially important source of error in clinical decision making; 4. Evaluate the potential of using parameters of genetic variation as biomarkers for response to treatment. To reach these aims we use a combination of traditional histopathology and next-generation sequencing technologies. We focus on three of the most common solid tumours in children: neuroblastoma, Wilms tumour and rhabdomyosarcoma.

Recent research outputs

Naveen Ravi, Minjun Yang, Sigurdur Gretarsson, Jansson, C., Mylona, N., Sydow, S. R., Eleanor L. Woodward, Lars Ekblad, Johan Wennerberg & Kajsa Paulsson, 2019 Mar 22, In : Cancers. 11, 3, 402.

Research output: Contribution to journalArticle

Linda Holmquist Mengelbier, Lindell-Munther, S., Hiroaki Yasui, Jansson, C., Esfandyari, J., Jenny Karlsson, Lau, K., Hui, C. C., Daniel Bexell, Hopyan, S. & David Gisselsson, 2019 Jan, In : Journal of Pathology. 247, 1

Research output: Contribution to journalArticle

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