Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Urology and Nephrology
- Immunology in the medical area
- Hemolytic uremic syndrome, vasculitis, microvesicles, Shiga toxin, kidney
Diana Karpman's project focuses on the pathogenesis of renal diseases and the infectious, inflammatory and prothrombotic mechanisms leading to acute and chronic renal failure. Novel mechanisms of disease propagation via blood-borne and cell-derived microvesicles as well as complement and kinin system activation are investigated. The diseases investigated are enterohemorrhagic Escherichia coli (EHEC) infection, hemolytic uremic syndrome, complement-mediated renal disease and vasculitis. Mechanisms by which tissue damage is induced are investigated to define the bacterial and host components causing disease. Defining mechanisms of complement and kinin system activation based on genetic and functional assays may explain why patients are prone to thrombosis and inflammation promoting progression of kidney disease. Ultimately, we aim to develop specific treatments to prevent the spread of bacterial virulence factors and neutralize detrimental activation of the complement and kinin systems.
Recent research outputs
Blockade of the kallikrein-kinin system reduces endothelial complement activation in vascular inflammationIngrid Lopatko Fagerström, Anne lie Ståhl, Maria Mossberg, Tati, R., Ann Charlotte Kristoffersson, Robin Kahn, Bascands, J. L., Klein, J., Schanstra, J. P., Mårten Segelmark & Diana Karpman, 2019 Aug 20, In : EBioMedicine.
Research output: Contribution to journal › Article
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