Pediatric Nephrology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Pediatrics
  • Urology and Nephrology
  • Immunology in the medical area

Keywords

  • Hemolytic uremic syndrome, vasculitis, microvesicles, Shiga toxin, kidney

Research

Diana Karpman's project focuses on the pathogenesis of renal diseases and the infectious, inflammatory and prothrombotic mechanisms leading to acute and chronic renal failure. Novel mechanisms of disease propagation via blood-borne and cell-derived microvesicles as well as complement and kinin system activation are investigated. The diseases investigated are enterohemorrhagic Escherichia coli (EHEC) infection, hemolytic uremic syndrome, complement-mediated renal disease and vasculitis. Mechanisms by which tissue damage is induced are investigated to define the bacterial and host components causing disease. Defining mechanisms of complement and kinin system activation based on genetic and functional assays may explain why patients are prone to thrombosis and inflammation promoting progression of kidney disease. Ultimately, we aim to develop specific treatments to prevent the spread of bacterial virulence factors and neutralize detrimental activation of the complement and kinin systems.

Recent research outputs

Diana Karpman & Ashmita Tontanahal, 2021 Aug 1, In: Free Radical Biology and Medicine. 171, p. 42-54 13 p.

Research output: Contribution to journalReview article

Milan Chromek, Asa Jungner, Niclas Rudolfson, David Ley, Detlef Bockenhauer & Lars Hagander, 2021 Apr 21, In: Archives of Disease in Childhood. 106, 5, p. 491-195 5 p.

Research output: Contribution to journalArticle

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