Organisational unit: Research group
Research areas and keywords
UKÄ subject classification
- Platelets, immunology, TRALI
Professor Semple joined St. Michaels Hospital in 1990 and was a Professor of Pharmacology at the University of Toronto. In 2016, he moved to Lund where he is a Professor of Transfusion Medicine and Group Leader in Platelet Immunology. He is a member of several organizations and has delivered over 150 presentations at international meetings. He is currently the Scientific Secretary of the ISBT, a member of the Scientific Committee on Megakaryocytes and Platelets of ASH and on the Editorial Board of Blood and Transfusion journals. His primary research interests include the pathogenesis of immune thrombocytopenia (ITP) where he studies animal models of platelet immunity. He also discovered Toll-like Receptors on platelets and has an interest in platelet-immune interactions. A third focus of his is understanding the pathogenic mechanisms that lead to Transfusion Related Acute Lung Injury (TRALI). He has authored more than 175 publications in the area of platelet immunology and TRALI.
Recent research outputs
FcγRI and FcγRIII on splenic macrophages mediate phagocytosis of anti-glycoprotein IIb/IIIa autoantibody-opsonized platelets in immune thrombocytopeniaPeter A.A. Norris, George B. Segel, W. Richard Burack, Ulrich J. Sachs, Suzanne N. Lissenberg-Thunnissen, Gestur Vidarsson, Behnaz Bayat, Christine M. Cserti-Gazdewich, Jeannie Callum, Yulia Lin, Donald R. Branch, Rick Kapur, John W. Semple & Alan H. Lazarus, 2021, In: Haematologica. 106, 1, p. 250-254 5 p.
Research output: Contribution to journal › Letter
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Platelet extracellular vesicles mediate transfusion-related acute lung injury by imbalancing the sphingolipid rheostatMark J. McVey, Sarah Weidenfeld, Mazharul Maishan, Chris Spring, Michael Kim, Arata Tabuchi, Victoria Srbely, Alisa Takabe-French, Szandor Simmons, Christoph Arenz, John W. Semple & Wolfgang M. Kuebler, 2021, In: Blood. 137, 5, p. 690-701 12 p.
Research output: Contribution to journal › Article