Protease Inhibitor Research

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Clinical Laboratory Medicine
  • Cell and Molecular Biology
  • Cancer and Oncology

Keywords

  • Proteases, proteinases, inhibitors, enzymes, protein structure, enzymology, kidney, inflammation, proteolytic

Description

Research

The aim of the the Protease Inhibitor Group is to elucidate how an important class of proteolytic enzymes, the cysteine proteases, are regulated in health and disease in order to understand how they can be targetted pharmacologically. Natural inhibitors of cysteine proteases are normally small proteins with structures complementary to the substrate binding clefts of their target enzymes. Such inhibitors are studied with respect to structure, function and biological activity in cell culture systems. A specific focus is on cancer research, to address the role of cystatins as markers and tumour suppressors. Another is to study cystatin C as a marker for kidney function and a third to reveal the mechanism leading to amyloidosis and brain haemorrhage due to aggregation of the inhibitor cystatin C. The work also includes research about proteases/inhibitors of pathogenic bacteria and parasites such as S. aureus , P. gingivalis and T. cruzi, and their interplay with host defense systems.

Recent research outputs

Arash Mokhtari, Ardavan Khoshnood, Jakob Lundager Forberg, Caroline Hård Af Segerstad, Ulf Ekström, Tommy Schyman, Mahin Akbarzadeh Mameghanilar, Bertil Lindahl & Ulf Ekelund, 2020 Nov, In: Cardiology. 145, 11, p. 685-692 8 p.

Research output: Contribution to journalArticle

Christel Nielsen, Ulrika Andersson Hall, Christian Lindh, Ulf Ekström, Yiyi Xu, Ying Li, Agneta Holmäng & Kristina Jakobsson, 2020 Jul 8, In: Environmental Health: A Global Access Science Source. 19, 1, 80.

Research output: Contribution to journalArticle

Jason Glaser, Erik Hansson, Ilana Weiss, Catharina Wesseling, Kristina Jakobsson, Ulf Ekström, Jenny Apelqvist, Rebekah Lucas, Esteban Arias Monge, Sandra Peraza, Christer Hogstedt & David H. Wegman, 2020 Jul, In: Occupational and environmental medicine. 77, 8, p. 527-534 8 p.

Research output: Contribution to journalArticle

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