Proteomic Hematology

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Hematopoieisis, stem cell, leukemia, proteomics, mass spectrometry

Description

Research

Proteins are the machinery of the cell, responsible for executing the functions essential for cells to operate, survive, differentiate and divide. In hematopoiesis, the proteomic make-up of blood stem cells and progenitors can regulate their cell fate and susceptibility to initiation as well as progression of leukemia. The broad interest of our group lies in understanding the molecular differences between fetal and adult hematopoiesis. By using in-depth mass spectrometry-based quantitative proteomics to monitor protein levels in a comprehensive and quantitative manner, our ongoing research aims at defining the fetal- and adult-specific proteomic programs that regulate normal and malignant hematopoiesis. Future work will include detailed proteomic profiling of ontogeny-specific leukemic features, investigation of the mechanistic details of hematopoietic stem cell plasticity, as well as specific types of post-translational modifications of particular importance in early hematopoiesis.

Recent research outputs

Simon Raffel, Daniel Klimmeck, Mattia Falcone, Aykut Demir, Alireza Pouya, Petra Zeisberger, Cristoph Lutz, Marco Tinelli, Oliver Bischel, Lars Bullinger, Christian Thiede, Anne Flörcken, Gerhard Ehninger, Anthony Ho, Carsten Müller-Tidow, Zuguang Gu, Carl Hermann, Jeroen Krijgsveld, Andreas Trumpp & Jenny Hansson, 2020 Jun 18, In : Blood.

Research output: Contribution to journalArticle

Marie E. Jönsson, Per Ludvik Brattås, Charlotte Gustafsson, Rebecca Petri, David Yudovich, Karolina Pircs, Shana Verschuere, Sofia Madsen, Jenny Hansson, Jonas Larsson, Robert Månsson, Alexander Meissner & Johan Jakobsson, 2019 Jul 18, In : Nature Communications. 10, 1, 3182.

Research output: Contribution to journalArticle

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