Redox Medicine

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Infectious Medicine


Redox reactions and oxidative stress has been implicated as an important factor in the progression of many disease conditions, such as hemorrhage, inflammation, infection, ischemia-reperfusion and tumor targeted radiation. During these conditions increased levels of free radicals are generated, causing an imbalance in the redox-system that leads to oxidation of cells and molecules and subsequent tissue and organ damage.


Hemolysis of erythrocytes releases high levels of cell-free hemoglobin and its metabolites, which are potentially dangerous molecules contributing to tissue and cell damage via redox-reactions. Our research aim to characterize these pathophysiological reactions mechanisms and their importance in diseases, focusing on the immature brain and kidneys. Furthermore, we study defense mechanisms that protect against these reactions with a special emphasis on the heme- and radical-scavenging protein A1M. Of particular interest is evaluating A1M as therapy for these conditions.

Recent research outputs

Praveen Papareddy, Rossnagel, M., Doreen Hollwedel, F., Kilic, G., Srinivas Veerla, Naudin, C., Emanuel Smeds, Westman, J., Martinez-Martinez, I., Arne Egesten, de la Morena-Barrio, M. E., Corral, J., Adam Linder, Artoni, A., Abbattista, M., Novembrino, C., Herbert Brakebusch, C., Martinelli, I., Kasetty, G. & Heiko Herwald, 2019 Sep 23, In : Nature Microbiology. p. 1-14

Research output: Contribution to journalArticle

Romantsik, O., Alex Adusei Agyemang, Sveinsdóttir, S., Rutardóttir, S., Holmqvist, B., Magnus Cinthio, Mörgelin, M., Gumus, G., Karlsson, H., Stefan R. Hansson, Bo Åkerström, David Ley & Magnus Gram, 2019 Jun 7, In : Journal of Neuroinflammation. 16, 1, 122.

Research output: Contribution to journalArticle

Alex Adusei Agyemang, Kristbjörg Sveinsdóttir, Suvi Vallius, SVEINSDOTTIR, SNJOLAUG., Matteo Bruschettini, Romantsik, O., Hellström, A., Smith, L. E. H., Ohlsson, L., Holmqvist, B., Magnus Gram & David Ley, 2017 Jun 10, In : Translational Stroke Research. p. 1-13 13 p.

Research output: Contribution to journalArticle

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