Stem Cell Metabolism

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology


  • Hematopoiesis, unfolded protein stress, red blood cell, bile acid, erythropoiesis



Hematopoiesis is a well-balanced system that requires both consistency and flexibility. Although the potential of hematopoietic stem cells (HSCs) has intensively been studied, contributions of these cells in different occasions and their regulations are still unclear. Our research group therefore aims to understand molecular mechanisms and cellular dynamics of HSCs, particularly under proliferative and stressed conditions. Concretely, we study (1) how different kinds of stress impact on cellular metabolism and stem cell heterogeneity, (2) how cells manage such stress conditions, and (3) what types of factors can play the role in the regulations. These are crucial for investigating molecular/cellular mechanisms involved in normal and malignant hematopoiesis, and also equally imperative for developing new technologies in order to expand/produce functional blood cells.

Recent research outputs

Els Mansell, Valgardur Sigurdsson, Elitza Deltcheva, John Brown, Chela James, Kenichi Miharada, Shamit Soneji, Jonas Larsson & Tariq Enver, 2021, In: Cell Stem Cell. 28, 2, p. 241-256.e6

Research output: Contribution to journalArticle

Valgardur Sigurdsson, Youichi Haga, Hajime Takei, Els Mansell, Chizuko Okamatsu-Haga, Mitsuyoshi Suzuki, Visnja Radulovic, Mark van der Garde, Shuhei Koide, Svetlana Soboleva, Mats Gåfvels, Hiroshi Nittono, Akira Ohara & Kenichi Miharada, 2020 May 12, In: Blood Advances. 4, 9, p. 1833-1843 11 p.

Research output: Contribution to journalArticle

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