Stem Cells to Red Blood Cells

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology

Keywords

  • Blood, stem cells, red blood cells, erythrocytes, anemia, diamond-blackfans anemia , direct reprogramming, hemoglobin, erythropoiesis

Description

Research

We research the generation of the most abundant cells in our bodies, the red blood cells. We are particularly interested in how this process is regulated and what goes wrong when a failure leads to anemia. Two main aims of the group are. 1. Develop novel therapies for patients with anemia that today lack effective therapy. - From different screening and medicinal chemistry approaches we are identifying drug candidates for treatment of anemia that are validated in anemic mouse models and on cells from patients with severe congenital anemia. 2. To understand the developmental process of red blood cell formation. - The group was the first to define the genetic code that instructs a cell to become an erythropoietin-sensitive erythroblast. - Through analysis of genome wide association studies and screening the group has identified several previously unknown genes that are essential for normal red cell production.

Recent research outputs

Zahra Masoumi, Maes, G. E., Herten, K., Cortés-Calabuig, Á., Abdul Ghani Alattar, Hanson, E., Lena Erlandsson, Mezey, E., Mattias Magnusson, Vermeesch, J. R., Mary Familari & Stefan R. Hansson, 2019 Apr 25, In : International Journal of Molecular Sciences. 20, 8, 2038.

Research output: Contribution to journalArticle

Siva, K., Fredrik Ek, Chen, J., Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

Research output: Contribution to journalArticle

Amirhosseini, M., Bernhardsson, M., Lång, P., Andersson, G., Johan Flygare & Fahlgren, A., 2019, In : Journal of Cellular Physiology. 234, 9, p. 16503-16516 14 p.

Research output: Contribution to journalArticle

View All (13)