Structural Biochemistry

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Other Basic Medicine

Description

The botulinum neurotoxins are the most toxic substances known; they are one million times more toxic than the cobra toxin. In spite of their extreme toxicity there has been a rapid expansion of the medical applications for the botulinum neurotoxins, with new applications constantly being discovered. This line of treatment is becoming the standard procedure for many conditions. The toxins are possible agents for bioterrorism and the development of countermeasures and vaccines are of high priority. We are studying the toxins using a wide variety of methods, including X-ray crystallography and cryo-EM to understand the toxins basic mechanism and to improve their therapeutic properties.

Research

We also study enzymes involved in the nucleotide metabolism. One example is MTH1, this protein is important for clearing oxidative damage from the nucleotide pool. Many types of cancer cells have high levels of oxidative damage and depend on MTH1 for survival. We use X-ray crystallography to study the binding of MTH1 to natural substrates and potent inhibitors that we are developing in an interdisciplinary research collaboration. We use structural based drug design to refine these inhibitors into novel cancer drugs.

Recent research outputs

Jonathan R Davies, Geoffrey Masuyer & Pål Stenmark, 2020 Sep 17, In : Toxins. 12, 9, 603.

Research output: Contribution to journalArticle

Markel Martínez-Carranza, Venkateswara Rao Jonna, Daniel Lundin, Margareta Sahlin, Lars-Anders Carlson, Newal Jemal, Martin Högbom, Britt-Marie Sjöberg, Pål Stenmark & Anders Hofer, 2020 Sep 3, In : The Journal of biological chemistry.

Research output: Contribution to journalArticle

Si Min Zhang, Matthieu Desroses, Anna Hagenkort, Nicholas C K Valerie, Daniel Rehling, Megan Carter, Olov Wallner, Tobias Koolmeister, Adam Throup, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Thomas Lundbäck, Hanna Axelsson, Shruti Regmi, Antonio Sarno, Andreas Krämer, Linda Pudelko, Lars Bräutigam, Azita Rasti & 17 others, Mona Göttmann, Elisée Wiita, Juliane Kutzner, Torsten Schaller, Christina Kalderén, Armando Cázares-Körner, Brent D G Page, Rosa Krimpenfort, Saeed Eshtad, Mikael Altun, Sean G Rudd, Stefan Knapp, Martin Scobie, Evert J Homan, Ulrika Warpman Berglund, Pål Stenmark & Thomas Helleday, 2020 Jul 20, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

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