Systemic Radiation Therapy Group

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • Nuclear Medicine, Medical Imaging, Molecular Imaging, Radioimmunotherapy, Radiation Therapy, Dosimetry, Prostate Cancer, hk2

Research

The main research area of the group is systemic treatment of metastasized cancer using therapeutic radionuclides. To optimize dose delivery to tumor cells, radionuclides are conjugated to tracer molecules, e.g. antibodies or antibody fragments, targeting cancer-specific epitopes. Preclinical evaluation of treatment combinations and strategies aim to improve treatment efficacy. Multimodality imaging such as SPECT/PET/CT, and Cerenkov and Bioluminescence Imaging are also employed to evaluate tracer biokinetics, biological effects and properties such as tumor uptake and penetration. Improving micro- and macro-scale dosimetry models and apply them using input from e.g. imaging modalities is another key aim. The group combines basic research with translational efforts, aiming to implement novel radionuclide therapies in the clinic. The current focus is on prostate cancer radioimmunotherapy targeting human kallikrein-related peptidase 2 (hK2), following promising preclinical results.

Recent research outputs

Irma Mahmutovic Persson, Hanna Falk Håkansson, Anders Örbom, Jian Liu, Karin von Wachenfeldt, Lars E. Olsson & the TRISTAN Consortium the TRISTAN Consortium, 2020 Jun 19, In : Frontiers in Physiology. 11, 584.

Research output: Contribution to journalArticle

Mesude Bicak, Katharina Lückerath, Teja Kalidindi, Michael E. Phelps, Sven Erik Strand, Michael J. Morris, Caius G. Radu, Robert Damoiseaux, Mari T. Peltola, Norbert Peekhaus, Austin Ho, Darren Veach, Ann Christin Malmborg Hager, Steven M. Larson, Hans Lilja, Michael R. McDevitt, Robert J. Klein & David Ulmert, 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 26, p. 15172-15181 10 p.

Research output: Contribution to journalArticle

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