The genetics of soft tissue tumors

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Medical Genetics


  • Sarcoma, diagnosis, Gene fusions



Soft tissue tumors (STT) constitute a heterogeneous group of neoplasms that clinically run the gamut from totally benign to highly malignant neoplasms. This clinical variability is reflected in the recognition of more than 100 histopathologic entities. Genetic analyses have provided a wealth of information on the genectic constitution of STT, and clearly nonrandom patterns of genetic changes, ranging from point mutations and gene fusions to massive genomic imbalalnces, have been identified in each histological entity studied in sufficient detail. The finding of a strong genotype-phenotype correlation has not only provided valuable clues to the cellular mechanisms behind STT development, but has also been of clinical significance by increasing the diagnostic accuracy. Our research activites concerning STT are focused on the characterization of the spectrum of acquired genetic changes occuring in vivo, using state of the art techniques. The aims of these studies are to identify genetic changes that are instrum

Recent research outputs

Jakob Hofvander, Jo, V. Y., Fletcher, C. D. M., Puls, F., Flucke, U., Nilsson, J., Magnusson, L. & Fredrik Mertens, 2020, In : Modern Pathology.

Research output: Contribution to journalArticle

Bertil Johansson, Fredrik Mertens, Schyman, T., Jonas Björk, Nils Mandahl & Felix Mitelman, 2019 Sep, In : Genes Chromosomes and Cancer. 58, 9, p. 607-611 5 p.

Research output: Contribution to journalArticle

View All (28)