Unit for Biological and Precision Psychiatry

Organisational unit: Research group

Description

Depression, Biomarkers, Clinical trials

Research

The overreaching hypothesis that frames our work is that depressive disorders are accompanied by, if not caused by, identifiable biological abnormalities that contribute to both the psychological and somatic aspects of these illnesses. This is a comprehensive hypothesis involving the study of several biomarkers including (but not limited to) cellular stress, inflammation, oxidative stress, mitochondrial dysfunction, vitamin D, neurotransmitters, gut microbiome and brain imaging. Treatment of depression is hampered by the failure to identify distinct symptom profiles with distinct pathophysiologies that differentially respond to distinct treatments. We use blood, brain, and feces biomarkers to delineate specific subgroups of depression, and test the antidepressant efficacy of various interventions targeting these specific biological pathways. The goal of our research program is to advance precision psychiatry by tailoring antidepressant treatments.

Recent research outputs

Aminata Ndiaye, Klara Suneson, Irene Njuguna, Gwen Ambler, Tomas Hanke, Grace John-Stewart, Walter Jaoko & Marie Reilly, 2020 Dec 2, In : Maternal and Child Nutrition.

Research output: Contribution to journalArticle

Kelsey R. Dean, Rasha Hammamieh, Synthia H. Mellon, Duna Abu-Amara, Janine D. Flory, Guia Guffanti, Kai Wang, Bernie J. Daigle, Aarti Gautam, Inyoul Lee, Ruoting Yang, Lynn M. Almli, F. Saverio Bersani, Nabarun Chakraborty, Duncan Donohue, Kimberly Kerley, Taek Kyun Kim, Eugene Laska, Min Young Lee, Daniel Lindqvist & 20 others, Adriana Lori, Liangqun Lu, Burook Misganaw, Seid Muhie, Jennifer Newman, Nathan D. Price, Shizhen Qin, Victor I. Reus, Carole Siegel, Pramod R. Somvanshi, Gunjan S. Thakur, Yong Zhou, The PTSD Systems Biology Consortium The PTSD Systems Biology Consortium, Leroy Hood, Kerry J. Ressler, Owen M. Wolkowitz, Rachel Yehuda, Marti Jett, Francis J. Doyle III & Charles Marmar, 2020 Dec, In : Molecular Psychiatry. 25, 12, p. 3337-3349 13 p.

Research output: Contribution to journalArticle

Christina M. Hough, F. Saverio Bersani, Synthia H. Mellon, Alexandra E. Morford, Daniel Lindqvist, Victor I. Reus, Elissa S. Epel & Owen M. Wolkowitz, 2020 May 22, In : Psychological Medicine.

Research output: Contribution to journalArticle

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