Unit for translational obstetric research
Organisational unit: Research group
Preeclampsia (PE) is a severe pregnancy-related condition affecting 10M women worldwide. The etiology is unknown and diagnosis based on maternal clinical symptoms: high blood pressure and organ damage manifesting after 20 weeks. Delivery is the only cure. Increased long-term risk for cardiovascular diseases and stroke after PE shows its seriousness. Reliable early diagnosis and prognosis, and effective treatment are urgently needed. Our research group focus on different aspects of PE; 1) molecular factors in the etiology, e.g. free fetal hemoglobin, globin and iron, 2) role of air pollution in PE, 3) evaluation of hemopexin and alpha-1-microglobulin as biomarkers for PE and intra uterine growth restriction, 4) gastrointestinal microbiota in PE, 5) vascular mechanisms involved in long-term risk for cardiovascular diseases after PE, 6) therapeutic approaches for PE in animal models, 7) document womens experiences from PE, 8) psychological mechanisms involved in decision making in obstetric emergencies.
Our research group has projects related to different aspects of preeclampsia; 1. To understand the molecular aspects of the etiology with special focus on free fetal hemoglobin, globin and iron. 2. To understand the role of air pollution in PE etiology. 3. To evaluate the scavenger proteins hemopexin, alpha-1-microglobulin and haptoglobin as predictive and diagnostic biomarkers for PE and IUGR. 4. To evaluate biomarkers and clinical parameters to predict eclampsia. 5. To understand how the gastrointestinal microbiota is affected by PE. 6. To reveal the vascular mechanisms causing the long-term risks for cardiovascular diseases. 7. Evaluate new therapeutic approaches for PE in established animal models. 8. To evaluate the womens aspect of having PE. 9. To understand the psychological mechanism in the decision making in obstetric emergency situations.
Recent research outputs
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Non-immune hydrops fetalis was rare in Sweden during 1997-2015, but cases were associated with complications and poor prognosisCatharina Whybra, Karin Källén, Stefan R. Hansson & Rolf Gunnarsson, 2020, In : Acta Paediatrica, International Journal of Paediatrics. 109, 12, p. 2570-2577 8 p.
Research output: Contribution to journal › Article