Urothelial Cancer Genomics

Organisational unit: Research group

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Research

Urothelial cancer, bladder cancer, is divided in two major subtypes, non-muscle invasive and muscle-invasive, with very distinct biological and clinical properties. Prognosis and treatment are mainly based on pathological criteria. The fact that only 20-25% of high grade low stage tumors are confirmed by review pathology, and that 30% of patients with intermediate stage tumors are upstaged after repeated transurethral resection (TUR), argues that standard pathological methods is unreliable for proper tumor assessment. To address these problems we have constructed a molecular taxonomy of urothelial cancer. This taxonomy is based on a combination of gene expression, epigenetic and genomic changes, and gene mutations analyses. The overall goal is to refine and optimize UC classification into molecular subtypes important for prognosis and treatment.

Recent research outputs

Sia Viborg Lindskrog, Frederik Prip, Philippe Lamy, Ann Taber, Clarice S. Groeneveld, Karin Birkenkamp-Demtröder, Jørgen Bjerggaard Jensen, Trine Strandgaard, Iver Nordentoft, Emil Christensen, Mateo Sokac, Nicolai J. Birkbak, Lasse Maretty, Gregers G. Hermann, Astrid C. Petersen, Veronika Weyerer, Marc Oliver Grimm, Marcus Horstmann, Gottfrid Sjödahl, Mattias Höglund & 27 others, Torben Steiniche, Karin Mogensen, Aurélien de Reyniès, Roman Nawroth, Brian Jordan, Xiaoqi Lin, Dejan Dragicevic, Douglas G. Ward, Anshita Goel, Carolyn D. Hurst, Jay D. Raman, Joshua I. Warrick, Ulrika Segersten, Danijel Sikic, Kim E.M. van Kessel, Tobias Maurer, Joshua J. Meeks, David J. DeGraff, Richard T. Bryan, Margaret A. Knowles, Tatjana Simic, Arndt Hartmann, Ellen C. Zwarthoff, Per Uno Malmström, Núria Malats, Francisco X. Real & Lars Dyrskjøt, 2021 Dec, In: Nature Communications. 12, 2301.

Research output: Contribution to journalArticle

Nour-Al-Dain Marzouka & Pontus Eriksson, 2021 Feb 5, (Accepted/In press) In: Bioinformatics (Oxford, England). 2 p., btab088.

Research output: Contribution to journalDebate/Note/Editorial

Joshua J. Meeks, Gottfrid Sjödahl, Seth P. Lerner, Arighno Das, David J. McConkey & Peter C. Black, 2021, In: Bladder Cancer. 7, 1, p. 1-11 11 p.

Research output: Contribution to journalReview article

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