Division of Molecular Medicine and Gene Therapy

Organisational unit: Division

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  1. 2020
  2. CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia

    Ramprasad Ramakrishnan, Pablo Peña-Martínez, Agarwal, P., Rodriguez-Zabala, M., Marion Chapellier, Högberg, C., Eriksson, M., David Yudovich, Shah, M., Mats Ehinger, Björn Nilsson, Jonas Larsson, Anna Hagström-Andersson, Ebert, B. L., Bhatia, R. & Marcus Järås, 2020 May 26, In : Cell Reports. 31, 8, 107684.

    Research output: Contribution to journalArticle

  3. Generation of gene-corrected functional osteoclasts from osteopetrotic induced pluripotent stem cells

    Xiaojie Xian, Moraghebi, R., Löfvall, H., Fasth, A., Henriksen, K., Johan Richter, Niels Bjarne Woods & Ilana Moscatelli, 2020 May 15, In : Stem Cell Research & Therapy. 11, 179.

    Research output: Contribution to journalArticle

  4. Induction of blood-circulating bile acids supports recovery from myelosuppressive chemotherapy

    Valgardur Sigurdsson, Haga, Y., Takei, H., Els Mansell, Okamatsu-Haga, C., Mitsuyoshi Suzuki, Visnja Radulovic, van der Garde, M., Koide, S., Svetlana Soboleva, Gåfvels, M., Nittono, H., Ohara, A. & Kenichi Miharada, 2020 May 12, In : Blood Advances. 4, 9, p. 1833-1843 11 p.

    Research output: Contribution to journalArticle

  5. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia

    Hochhaus, A., Baccarani, M., Silver, R. T., Schiffer, C., Apperley, J. F., Cervantes, F., Clark, R. E., Cortes, J. E., Deininger, M. W., Guilhot, F., Hjorth-Hansen, H., Hughes, T. P., Janssen, J. J. W. M., Kantarjian, H. M., Kim, D. W., Larson, R. A., Lipton, J. H., Mahon, F. X., Mayer, J., Nicolini, F. & 14 others, Niederwieser, D., Pane, F., Radich, J. P., Rea, D., J. Richter, Rosti, G., Rousselot, P., Saglio, G., Saußele, S., Soverini, S., Steegmann, J. L., Turkina, A., Zaritskey, A. & Hehlmann, R., 2020 Mar 3, In : Leukemia.

    Research output: Contribution to journalReview article

  6. A SOX2 reporter system identifies gastric cancer stem-like cells sensitive to monensin

    Pádua, D., Barros, R., Amaral, A. L., Mesquita, P., Freire, A. F., Sousa, M., Maia, A. F., Inês Caiado, Fernandes, H., Pombinho, A., Carlos Filipe Pereira & Almeida, R., 2020, In : Cancers. 12, 2, 495.

    Research output: Contribution to journalArticle

  7. Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase

    Wilkes, M. C., Siva, K., Chen, J., Varetti, G., Youn, M. Y., Chae, H., Ek, F., Olsson, R., Lundbäck, T., Dever, D. P., Nishimura, T., Narla, A., Glader, B., Nakauchi, H., Porteus, M. H., Repellin, C. E., Gazda, H. T., Lin, S., Serrano, M., Flygare, J. & 1 others, Sakamoto, K. M., 2020, In : Nature Communications. 11, 1, 3344.

    Research output: Contribution to journalArticle

  8. 2019
  9. The Role of Intracellular Calcium Signaling in Hematopoietic Stem Cells

    Hooi Min Tan Grahn, 2019 Dec 24, In : Genomics & Gene Therapy International Journal. 3, 1, p. 1-4

    Research output: Contribution to journalReview article

  10. Understanding and Modulating Immunity With Cell Reprogramming

    Cristiana F. Pires, Fábio F. Rosa, Kurochkin, I. & Carlos Filipe Pereira, 2019 Dec 11, In : Frontiers in Immunology. 10, 2809.

    Research output: Contribution to journalReview article

  11. Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors

    Rita Silvério-Alves, Gomes, A. M., Kurochkin, I., Moore, K. A. & Carlos Filipe Pereira, 2019 Nov 4, In : Journal of visualized experiments : JoVE. 153

    Research output: Contribution to journalArticle

  12. Activation of neuronal genes via LINE-1 elements upon global DNA demethylation in human neural progenitors

    Marie E. Jönsson, Ludvik Brattås, P., Gustafsson, C., Petri, R., David Yudovich, Karolina Pircs, Verschuere, S., Madsen, S., Jenny Hansson, Jonas Larsson, Månsson, R., Meissner, A. & Johan Jakobsson, 2019 Jul 18, In : Nature Communications. 10, 1, 3182.

    Research output: Contribution to journalArticle

  13. Preeclampsia is Associated with Sex-Specific Transcriptional and Proteomic Changes in Fetal Erythroid Cells

    Zahra Masoumi, Maes, G. E., Herten, K., Cortés-Calabuig, Á., Abdul Ghani Alattar, Hanson, E., Lena Erlandsson, Mezey, E., Mattias Magnusson, Vermeesch, J. R., Familari, M. & Stefan R. Hansson, 2019 Apr 25, In : International Journal of Molecular Sciences. 20, 8, 2038.

    Research output: Contribution to journalArticle

  14. HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

    Kumar, P., Beck, D., Roman Galeev, Thoms, J. A. I., Mehrnaz Safaee Talkhoncheh, Ineke de Jong, Unnikrishnan, A., Aurélie Baudet, Agatheeswaran Subramaniam, Pimanda, J. E. & Jonas Larsson, 2019 Feb 26, In : Blood Advances. 3, 4, p. 681-691 11 p.

    Research output: Contribution to journalArticle

  15. The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

    Melissaridou, S., Wiechec, E., Magan, M., Jain, M. V., Chung, M. K., Farnebo, L. & Roberg, K., 2019 Jan 14, In : Cancer Cell International. 19, 1, 16.

    Research output: Contribution to journalArticle

  16. A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model

    Katri, A., Dąbrowska, A., Löfvall, H., Karsdal, M. A., Andreassen, K. V., Thudium, C. S. & Henriksen, K., 2019, In : Osteoarthritis and Cartilage. 27, 9, p. 1339-1346

    Research output: Contribution to journalArticle

  17. A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

    Siva, K., Fredrik Ek, Jun Chen, Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

    Research output: Contribution to journalArticle

  18. Autoantibodies in Pandemrix®-induced narcolepsy: Nine candidate autoantigens fail the conformational autoantibody test

    Wallenius, M., Alexander Lind, Akel, O., Karlsson, E., Svensson, M., Arvidsson, E., Ramelius, A., Törn, C., Palm, L., Åke Lernmark & Helena Elding Larsson, 2019, In : Autoimmunity. 52, 4, p. 185-191 7 p.

    Research output: Contribution to journalArticle

  19. Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model

    Katri, A., Dąbrowska, A., Löfvall, H., Ding, M., Karsdal, M. A., Andreassen, K. V., Thudium, C. S. & Henriksen, K., 2019, In : Arthritis Research & Therapy. 21, 1, 68.

    Research output: Contribution to journalArticle

  20. Cyclin-dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing

    Amirhosseini, M., Bernhardsson, M., Lång, P., Andersson, G., Johan Flygare & Fahlgren, A., 2019, In : Journal of Cellular Physiology. 234, 9, p. 16503-16516 14 p.

    Research output: Contribution to journalArticle

  21. Ex Vivo Expansion of Human Hematopoietic Stem Cells

    Mehrnaz Safaee Talkhoncheh, 2019, Lund: Lund University: Faculty of Medicine. 100 p.

    Research output: ThesisDoctoral Thesis (compilation)

  22. Genome-wide mapping of bivalent histone modifications in hepatic stem/progenitor cells

    Kanayama, K., Chiba, T., Oshima, M., Kanzaki, H., Koide, S., Saraya, A., Miyagi, S., Mimura, N., Kusakabe, Y., Saito, T., Ogasawara, S., Suzuki, E., Ooka, Y., Maruyama, H., Iwama, A. & Kato, N., 2019, In : Stem Cells International. 2019, 9789240.

    Research output: Contribution to journalArticle

  23. GPDPLQ1237—A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro

    Löfvall, H., Katri, A., Dąbrowska, A., Karsdal, M. A., Luo, Y., He, Y., Manon-Jensen, T., Dziegiel, M. H., Bay-Jensen, A-C., Thudium, C. S. & Henriksen, K., 2019, In : Scientific Reports. 9, 3050.

    Research output: Contribution to journalArticle

  24. Hematopoietic stem cell-targeted neonatal gene therapy with a clinically applicable lentiviral vector corrects osteopetrosis in oc/oc Mice

    Löfvall, H., Rothe, M., Schambach, A., Henriksen, K., Johan Richter & Ilana Moscatelli, 2019, In : Human Gene Therapy. 30, 11, p. 1395-1404 10 p.

    Research output: Contribution to journalArticle

  25. Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture

    Daniel, M. G., Sachs, D., Bernitz, J. M., Fstkchyan, Y., Rapp, K., Satija, N., Law, K., Patel, F., Gomes, A. M., Kim, H. S., Carlos Filipe Pereira, Chen, B., Lemischka, I. R. & Moore, K. A., 2019, In : FEBS Letters. 593, 23, p. 3266-3287

    Research output: Contribution to journalArticle

  26. Is immunotherapy the holy grail for pancreatic cancer?

    Roland Andersson, Carlos Filipe Pereira, Bauden, M. & Daniel Ansari, 2019, In : Immunotherapy. 11, 17, p. 1435-1438 4 p.

    Research output: Contribution to journalDebate/Note/Editorial

  27. Junctional Adhesion Molecule 2 Represents a Subset of Hematopoietic Stem Cells with Enhanced Potential for T Lymphopoiesis

    Visnja Radulovic, van der Garde, M., Koide, S., Valgardur Sigurdsson, Stefan Lang, Kaneko, S. & Kenichi Miharada, 2019, In : Cell Reports. 27, 10, p. 2826-2836.e5

    Research output: Contribution to journalArticle

  28. MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2

    Yang Liu, Feng, L., Xu, J., Yang, Z., Wu, T., Zhang, J., Shi, L., Zhu, D., Zhang, J. & Li, G., 2019, In : Stem Cell Research and Therapy. 10, 1, 108.

    Research output: Contribution to journalArticle

  29. Protein biomarkers associated with pain mechanisms in osteoarthritis

    Thudium, C. S., Löfvall, H., Karsdal, M. A., Bay-Jensen, A. C. & Bihlet, A. R., 2019, In : Journal of Proteomics. 190, p. 55-66

    Research output: Contribution to journalArticle

  30. 2018
  31. Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

    Melissa Ilsley, Sandra Capellera-Garcia, Dhulipala, K., Johansson, A. & Johan Flygare, 2018 Dec 14, In : Journal of visualized experiments : JoVE. 142, e58464.

    Research output: Contribution to journalArticle

  32. Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

    Fábio F. Rosa, Cristiana F. Pires, Kurochkin, I., Alexandra G. Ferreira, Gomes, A. M., Palma, L. G., Shaiv, K., Solanas, L., Azenha, C., Papatsenko, D., Schulz, O., E Sousa, C. R. & Carlos Filipe Pereira, 2018 Dec 7, In : Science Immunology. 3, 30, eaau4292.

    Research output: Contribution to journalArticle

  33. Prospective evaluation of a combination of fungal biomarkers for the diagnosis of invasive fungal disease in high-risk haematology patients

    Hammarström, H., Stjärne Aspelund, A., Bertil Christensson, Heußel, C. P., Isaksson, J., Kondori, N., Lennart Larsson, Markowicz, P., Johan Richter, Wennerås, C. & Friman, V., 2018 Sep 1, In : Mycoses. 61, 9, p. 623-632 10 p.

    Research output: Contribution to journalArticle

  34. Fetal gene therapy for neurodegenerative disease of infants

    Massaro, G., Mattar, C. N. Z., Wong, A. M. S., Sirka, E., Buckley, S. M. K., Herbert, B. R., Karlsson, S., Perocheau, D. P., Burke, D., Heales, S., Richard-Londt, A., Brandner, S., Huebecker, M., Priestman, D. A., Platt, F. M., Mills, K., Biswas, A., Cooper, J. D., Chan, J. K. Y., Cheng, S. H. & 2 others, Waddington, S. N. & Rahim, A. A., 2018 Sep, In : Nature Medicine. 24, 9, p. 1317-1323

    Research output: Contribution to journalLetter

  35. Tipping clonal hematopoiesis into transformation

    Stefan Karlsson, 2018 Jul 19, In : New England Journal of Medicine. 379, 3, p. 295-296 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  36. Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes

    Löfvall, H., Newbould, H., Karsdal, M. A., Dziegiel, M. H., Johan Richter, Henriksen, K. & Thudium, C. S., 2018 Apr 10, In : Arthritis Research and Therapy. 20, 1, 67.

    Research output: Contribution to journalArticle

  37. A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

    Martin Gonzalez, J., Aurélie Baudet, Abelechian, S., Bonderup, K., d'Altri, T., Porse, B., Brakebusch, C., Gunnar Juliusson & Cammenga, J., 2018, In : Genesis. 56, 9, e23238.

    Research output: Contribution to journalArticle

  38. Cohesin in haematopoiesis and leukaemia

    Roman Galeev & Jonas Larsson, 2018, In : Current Opinion in Hematology. 25, 4, p. 259-265 7 p.

    Research output: Contribution to journalReview article

  39. Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

    Gomes, A. M., Kurochkin, I., Chang, B., Daniel, M., Law, K., Satija, N., Lachmann, A., Wang, Z., Ferreira, L., Ma'ayan, A., Chen, B. K., Papatsenko, D., Lemischka, I. R., Moore, K. A. & Carlos Filipe Pereira, 2018, In : Cell Reports.

    Research output: Contribution to journalArticle

  40. Development of Novel Therapies, Models, and Biomarkers for Osteoclast-Related Diseases

    Löfvall, H., 2018, Lund: Lund University: Faculty of Medicine. 114 p.

    Research output: ThesisDoctoral Thesis (compilation)

  41. Direct role of FLT3 in regulation of early lymphoid progenitors

    Zriwil, A., Charlotta Böiers, Trine A. Kristiansen, Wittmann, L., Joan Yuan, Nerlov, C., Ewa Sitnicka & Jacobsen, S. E. W., 2018, In : British Journal of Haematology. 183, 4, p. 588-600

    Research output: Contribution to journalArticle

  42. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach.

    Roman Galeev, 2018, Lund: Lund University: Faculty of Medicine. 127 p.

    Research output: ThesisDoctoral Thesis (compilation)

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