Division of Molecular Medicine and Gene Therapy

Organisational unit: Division

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  1. 2019
  2. HMGA2 promotes long-term engraftment and myeloerythroid differentiation of human hematopoietic stem and progenitor cells

    Kumar, P., Beck, D., Roman Galeev, Thoms, J. A. I., Mehrnaz Safaee Talkhoncheh, de Jong, I., Unnikrishnan, A., Aurélie Baudet, Agatheeswaran Subramaniam, Pimanda, J. E. & Jonas Larsson, 2019 Feb 26, In : Blood Advances. 3, 4, p. 681-691 11 p.

    Research output: Contribution to journalArticle

  3. The effect of 2D and 3D cell cultures on treatment response, EMT profile and stem cell features in head and neck cancer 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

    Melissaridou, S., Wiechec, E., Magan, M., Mayur Vilas Jain, Chung, M. K., Farnebo, L. & Roberg, K., 2019 Jan 14, In : Cancer Cell International. 19, 1, 16.

    Research output: Contribution to journalArticle

  4. A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia

    Siva, K., Fredrik Ek, Chen, J., Abdul Ghani Alattar, Sigmundsson, K., Roger Olsson, Wlodarski, M., Lundbäck, T. & Johan Flygare, 2019, In : SLAS discovery : advancing life sciences R & D. 24, 3, p. 304-313 10 p.

    Research output: Contribution to journalArticle

  5. Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model

    Katri, A., Dąbrowska, A., Löfvall, H., Ding, M., Karsdal, M. A., Andreassen, K. V., Thudium, C. S. & Henriksen, K., 2019, In : Arthritis Research & Therapy. 21, 1, 68.

    Research output: Contribution to journalArticle

  6. Ex Vivo Expansion of Human Hematopoietic Stem Cells

    Mehrnaz Safaee Talkhoncheh, 2019, Lund: Lund University, Faculty of Medicine. 100 p.

    Research output: ThesisDoctoral Thesis (compilation)

  7. GPDPLQ1237—A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro

    Löfvall, H., Katri, A., Dąbrowska, A., Karsdal, M. A., Luo, Y., He, Y., Manon-Jensen, T., Dziegiel, M. H., Bay-Jensen, A-C., Thudium, C. S. & Henriksen, K., 2019, In : Scientific Reports. 9, 3050.

    Research output: Contribution to journalArticle

  8. MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2

    Yang Liu, Feng, L., Xu, J., Yang, Z., Wu, T., Zhang, J., Shi, L., Zhu, D., Zhang, J. & Li, G., 2019, In : Stem Cell Research and Therapy. 10, 1, 108.

    Research output: Contribution to journalArticle

  9. Protein biomarkers associated with pain mechanisms in osteoarthritis

    Thudium, C. S., Löfvall, H., Karsdal, M. A., Bay-Jensen, A. C. & Bihlet, A. R., 2019, In : Journal of Proteomics. 190, p. 55-66

    Research output: Contribution to journalArticle

  10. 2018
  11. Direct Lineage Reprogramming of Adult Mouse Fibroblast to Erythroid Progenitors

    Melissa Ilsley, Sandra Capellera-Garcia, Dhulipala, K., Johansson, A. & Johan Flygare, 2018 Dec 14, In : Journal of visualized experiments : JoVE. 142, e58464.

    Research output: Contribution to journalArticle

  12. Direct reprogramming of fibroblasts into antigen-presenting dendritic cells

    Fábio F. Rosa, Cristiana F. Pires, Kurochkin, I., Alexandra G. Ferreira, Gomes, A. M., Palma, L. G., Shaiv, K., Solanas, L., Azenha, C., Papatsenko, D., Schulz, O., E Sousa, C. R. & Carlos Filipe Pereira, 2018 Dec 7, In : Science immunology. 3, 30, eaau4292.

    Research output: Contribution to journalArticle

  13. Prospective evaluation of a combination of fungal biomarkers for the diagnosis of invasive fungal disease in high-risk haematology patients

    Hammarström, H., Stjärne Aspelund, A., Bertil Christensson, Heußel, C. P., Isaksson, J., Kondori, N., Lennart Larsson, Markowicz, P., Johan Richter, Wennerås, C. & Friman, V., 2018 Sep 1, In : Mycoses. 61, 9, p. 623-632 10 p.

    Research output: Contribution to journalArticle

  14. Fetal gene therapy for neurodegenerative disease of infants

    Massaro, G., Mattar, C. N. Z., Wong, A. M. S., Sirka, E., Buckley, S. M. K., Herbert, B. R., Karlsson, S., Perocheau, D. P., Burke, D., Heales, S., Richard-Londt, A., Brandner, S., Huebecker, M., Priestman, D. A., Platt, F. M., Mills, K., Biswas, A., Cooper, J. D., Chan, J. K. Y., Cheng, S. H. & 2 othersWaddington, S. N. & Rahim, A. A., 2018 Sep, In : Nature Medicine. 24, 9, p. 1317-1323

    Research output: Contribution to journalLetter

  15. Tipping clonal hematopoiesis into transformation

    Stefan Karlsson, 2018 Jul 19, In : New England Journal of Medicine. 379, 3, p. 295-296 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  16. Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes

    Löfvall, H., Newbould, H., Karsdal, M. A., Dziegiel, M. H., Johan Richter, Henriksen, K. & Thudium, C. S., 2018 Apr 10, In : Arthritis Research and Therapy. 20, 1, 67.

    Research output: Contribution to journalArticle

  17. A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines

    Martin Gonzalez, J., Aurélie Baudet, Abelechian, S., Bonderup, K., d'Altri, T., Porse, B., Brakebusch, C., Gunnar Juliusson & Cammenga, J., 2018, In : Genesis. 56, 9, e23238.

    Research output: Contribution to journalArticle

  18. Cohesin in haematopoiesis and leukaemia

    Roman Galeev & Jonas Larsson, 2018, In : Current Opinion in Hematology. 25, 4, p. 259-265 7 p.

    Research output: Contribution to journalReview article

  19. Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming

    Gomes, A. M., Kurochkin, I., Chang, B., Daniel, M., Law, K., Satija, N., Lachmann, A., Wang, Z., Ferreira, L., Ma'ayan, A., Chen, B. K., Papatsenko, D., Lemischka, I. R., Moore, K. A. & Carlos Filipe Pereira, 2018, In : Cell Reports.

    Research output: Contribution to journalArticle

  20. Development of Novel Therapies, Models, and Biomarkers for Osteoclast-Related Diseases

    Löfvall, H., 2018, Lund: Lund University, Faculty of Medicine. 114 p.

    Research output: ThesisDoctoral Thesis (compilation)

  21. Direct role of FLT3 in regulation of early lymphoid progenitors

    Zriwil, A., Charlotta Böiers, Trine A. Kristiansen, Wittmann, L., Joan Yuan, Nerlov, C., Ewa Sitnicka & Jacobsen, S. E. W., 2018, In : British Journal of Haematology. 183, 4, p. 588-600

    Research output: Contribution to journalArticle

  22. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach.

    Roman Galeev, 2018, Lund: Lund University, Faculty of Medicine. 127 p.

    Research output: ThesisDoctoral Thesis (compilation)

  23. In vitro tumorigenic assay: colony forming assay for cancer stem cells

    Rajendran, V. & Mayur Vilas Jain, 2018, Methods in Molecular Biology. Humana Press, Vol. 1692. p. 89-95 7 p. (Methods in Molecular Biology; vol. 1692).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  24. On new and current treatments for Diamond-Blackfan anemia

    Sara Sjögren, 2018, Lund: Lund University, Faculty of Medicine. 80 p.

    Research output: ThesisDoctoral Thesis (compilation)

  25. Pentaisomaltose, an Alternative to DMSO. Engraftment of Cryopreserved Human CD34+ Cells in Immunodeficient NSG Mice

    Svalgaard, J. D., Mehrnaz Safaee Talkhoncheh, Haastrup, E. K., Munthe-Fog, L., Clausen, C., Hansen, M. B., Andersen, P., Gørløv, J. S., Jonas Larsson & Fischer-Nielsen, A., 2018, In : Cell Transplantation. 27, 9, p. 1407-1412 6 p.

    Research output: Contribution to journalArticle

  26. Programming Blood Cell Fates. Insights from Direct Lineage Conversion and Development

    Sandra Capellera Garcia, 2018, Lund: Lund University, Faculty of Medicine. 111 p.

    Research output: ThesisDoctoral Thesis (compilation)

  27. Targeting NSG Mice Engrafting Cells with a Clinically Applicable Lentiviral Vector Corrects Osteoclasts in Infantile Malignant Osteopetrosis

    Ilana Moscatelli, Löfvall, H., Schneider Thudium, C., Rothe, M., Montano, C., Kertész, Z., Sirin, M., Schulz, A., Schambach, A., Henriksen, K. & Johan Richter, 2018, In : Human Gene Therapy. 29, 8, p. 938-949

    Research output: Contribution to journalArticle

  28. The Role of Hepatic Leukemia Factor in Hematopoiesis

    Komorowska, K., 2018, Lund: Lund University, Faculty of Medicine. 100 p.

    Research output: ThesisDoctoral Thesis (compilation)

  29. 2017
  30. Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration

    Komorowska, K., Alexander Doyle, Martin Wahlestedt, Agatheeswaran Subramaniam, Debnath, S., Chen, J., Shamit Soneji, Van Handel, B., Mikkola, H. K. A., Kenichi Miharada, David Bryder, Jonas Larsson & Mattias Magnusson, 2017 Dec 19, In : Cell Reports. 21, 12, p. 3514-3523 10 p.

    Research output: Contribution to journalArticle

  31. Critical Modulation of Hematopoietic Lineage Fate by Hepatic Leukemia Factor

    Martin Wahlestedt, Ladopoulos, V., Isabel Hidalgo, Sanchez Castillo, M., Hannah, R., Petter Säwén, Haixia Wan, Monika Dudenhöffer-Pfeifer, Mattias Magnusson, Norddahl, G. L., Göttgens, B. & David Bryder, 2017 Nov 21, In : Cell Reports. 21, 8, p. 2251-2263 13 p.

    Research output: Contribution to journalArticle

  32. Signaling via Smad2 and Smad3 is dispensable for adult murine hematopoietic stem cell function in vivo

    Billing, M., Rörby, E., Maria Dahl, Blank, U., Andradottír, S., Mats Ehinger & Stefan Karlsson, 2017 Nov, In : Experimental Hematology.

    Research output: Contribution to journalArticle

  33. Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells

    Eriksson, M., Pablo Peña-Martínez, Ramprasad Ramakrishnan, Chapellier, M., Högberg, C., Glowacki, G., Christina Orsmark-Pietras, Velasco-Hernández, T., Lazarević, V. L., Gunnar Juliusson, Cammenga, J., Mulloy, J. C., Johan Richter, Thoas Fioretos, Ebert, B. L. & Marcus Järås, 2017 Oct 24, In : Blood Advances. 1, 23, p. 2046-2057 12 p.

    Research output: Contribution to journalArticle

  34. The stem cell regulator PEDF is dispensable for maintenance and function of hematopoietic stem cells

    Rörby, E., Billing, M., Maria Dahl, Sarah Warsi, Andradottir, S., Kenichi Miharada, Siva, K., Jönsson, J-I., Blank, U., Göran Karlsson & Stefan Karlsson, 2017 Aug 31, In : Scientific Reports. 7, 10134.

    Research output: Contribution to journalArticle

  35. No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: A population-based study in Sweden

    Gunnarsson, N., Höglund, M., Stenke, L., Sandin, F., Björkholm, M., Dreimane, A., Lambe, M., Markevärn, B., Olsson-Strömberg, U., Wadenvik, H., J. Richter & Själander, A., 2017 Aug 1, In : Leukemia. 31, 8, p. 1825-1827 3 p.

    Research output: Contribution to journalLetter

  36. Barcodes show family trees in ALL

    Jonas Larsson, 2017 Jun 15, In : Blood. 129, 24, p. 3139-3140 2 p.

    Research output: Contribution to journalDebate/Note/Editorial

  37. Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia

    Ilander, M., Olsson-Strömberg, U., Schlums, H., Guilhot, J., Brück, O., Lähteenmäki, H., Kasanen, T., Koskenvesa, P., Söderlund, S., Höglund, M., Markevärn, B., Själander, A., Lotfi, K., Dreimane, A., Lübking, A., Holm, E., Björeman, M., Lehmann, S., Stenke, L., Ohm, L. & 11 othersGedde-Dahl, T., Majeed, W., H. Ehrencrona, Koskela, S., Saussele, S., Mahon, F. X., Porkka, K., Hjorth-Hansen, H., Bryceson, Y. T., J. Richter & Mustjoki, S., 2017 May 1, In : Leukemia. 31, 5, p. 1108-1116 9 p.

    Research output: Contribution to journalArticle

  38. Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition

    Guibentif, C., Roger Emanuel Rönn, Charlotta Böiers, Lang, S., Saxena, S., Shamit Soneji, Tariq Enver, Göran Karlsson & Niels-Bjarne Woods, 2017 Apr 4, In : Cell Reports. 19, 1, p. 10-19 10 p.

    Research output: Contribution to journalArticle

  39. Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML

    Rebecca Warfvinge, Linda Geironson Ulfsson, Mikael N E Sommarin, Lang, S., Christine Karlsson, Roschupkina, T., Stenke, L., Stentoft, J., Olsson-Strömberg, U., Hjorth-Hansen, H., Mustjoki, S., Shamit Soneji, Johan Richter & Göran Karlsson, 2017 Apr, In : Blood. 129, 17, p. 2384-2394

    Research output: Contribution to journalArticle

  40. Cytohesin 1 regulates homing and engraftment of human hematopoietic stem and progenitor cells

    Rak, J., Foster, K., Kasia Potrzebowska, Mehrnaz Safaee Talkhoncheh, Natsumi Miharada, Komorowska, K., Therese Torngren, Anders Kvist, Åke Borg, Lena Svensson, Bonnet, D. & Jonas Larsson, 2017 Feb 23, In : Blood. 129, 8, p. 950-958 9 p.

    Research output: Contribution to journalArticle

  41. Direct lineage reprogramming: a useful addition to the blood cell research toolbox

    Sandra Capellera-Garcia & Johan Flygare, 2017 Feb 1, In : Expert Review of Hematology. 10, 2, p. 107-109

    Research output: Contribution to journalDebate/Note/Editorial

  42. Reactive Oxygen Species Impair the Function of CD90+ Hematopoietic Progenitors Generated from Human Pluripotent Stem Cells

    Roger E. Rönn, Guibentif, C., Saxena, S. & Niels Bjarne Woods, 2017 Jan 1, In : Stem Cells. 35, 1, p. 197-206 10 p.

    Research output: Contribution to journalArticle

  43. Advanced phase chronic myeloid leukaemia (CML) in the tyrosine kinase inhibitor era - a report from the Swedish CML register

    Söderlund, S., Dahlén, T., Sandin, F., Olsson-Strömberg, U., Creignou, M., Dreimane, A., Lübking, A., Markevärn, B., Själander, A., Wadenvik, H., Stenke, L., Johan Richter & Höglund, M., 2017 Jan, In : European Journal of Haematology. 98, 1, p. 57-66

    Research output: Contribution to journalArticle

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