Epilepsy Center
Organisational unit: Division
- 2020
Early infantile epileptic encephalopathy due to biallelic pathogenic variants in PIGQ: Report of seven new subjects and review of the literature
Devon L. Johnstone, Thi Tuyet Mai Nguyen, Jessica Zambonin, Kristin D. Kernohan, Anik St-Denis, Nissan V. Baratang, Taila Hartley, Michael T. Geraghty, Julie Richer, Jacek Majewski, Eric Bareke, Andrea Guerin, Manuela Pendziwiat, Loren D.M. Pena, Hilde M.H. Braakman, Karen W. Gripp, Andrew C. Edmondson, Miao He, Rebecca C. Spillmann, Erik A. Eklund & 4 others, , 2020 Nov, In : Journal of Inherited Metabolic Disease. 43, 6, p. 1321-1332 12 p.Research output: Contribution to journal › Article
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Predominant and novel de novo variants in 29 individuals with ALG13 deficiency: Clinical description, biomarker status, biochemical analysis, and treatment suggestions
Undiagnosed Diseases Network Undiagnosed Diseases Network, Bobby G Ng, Erik Eklund & Hudson H. Freeze, 2020 Nov, In : Journal of Inherited Metabolic Disease. 43, 6, p. 1333-1348 16 p.Research output: Contribution to journal › Article
Neuropsychological outcome after cardiac arrest: A prospective case control sub-study of the Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest trial (TTM2)
Erik Blennow Nordström, Gisela Lilja, Susanna Vestberg, Susann Ullén, Hans Friberg, Niklas Nielsen, Katarina Heimburg, Lars Evald, Marco Mion, Magnus Segerström, Anders M. Grejs, Thomas Keeble, Hans Kirkegaard, Hanna Ljung, Sofia Rose, Matthew P. Wise, Christian Rylander, Johan Undén & Tobias Cronberg, 2020 Oct 7, In : BMC Cardiovascular Disorders. 20, 1, 439.Research output: Contribution to journal › Article
Evidence-based Anti-seizure Monotherapy in Newly Diagnosed Epilepsy: a New Approach
MARIA COMPAGNO STRANDBERG, Karin Söderberg-Löfdal, Elin Kimland, Maria Dahlin & Kristina Kallen, 2020 Oct, In : Acta Neurologica Scandinavica. 142, 4, p. 323-332 10 p.Research output: Contribution to journal › Article
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Professionen har varit snabb att ta till sig nya läkemedel
Kristina Kallen, MARIA COMPAGNO STRANDBERG & Karin Söderberg-Löfdal, 2020 Oct, In : Läkartidningen.Research output: Contribution to journal › Debate/Note/Editorial
Tensor-valued diffusion MRI differentiates cortex and white matter in malformations of cortical development associated with epilepsy
Björn Lampinen, Ariadne Zampeli, Isabella M. Björkman-Burtscher, Filip Szczepankiewicz, Kristina Källén, Maria Compagno Strandberg & Markus Nilsson, 2020 Jul, In : Epilepsia. 61, 8, p. 1701-1713Research output: Contribution to journal › Article
Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor.
Esbjörn Melin, 2020, Lund: Lund University, Faculty of Medicine. 100 p.Research output: Thesis › Doctoral Thesis (compilation)
Development and Validation of CRISPR Activator Systems for Overexpression of CB1 Receptors in Neurons
Valentina Di Maria, Marine Moindrot, Martin Ryde, Antonino Bono, Luis Quintino & Marco Ledri, 2020, In : Frontiers in Molecular Neuroscience. 13, 168.Research output: Contribution to journal › Article
Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats
Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia & David Paul Drucker Woldbye, 2020, In : Frontiers in Molecular Neuroscience. 13, 232.Research output: Contribution to journal › Article
- 2019
Disease Modification by Combinatorial Single Vector Gene Therapy: A Preclinical Translational Study in Epilepsy
Esbjörn Melin, Avtandil Nanobashvili, Una Avdic, Casper R. Gøtzsche, My Andersson, David P.D. Woldbye & Merab Kokaia, 2019 Dec 13, In : Molecular Therapy - Methods and Clinical Development. 15, p. 179-193 15 p.Research output: Contribution to journal › Article
In vivo assessment of anticoagulant and antiplatelet effects of Syzygium cumini leaves extract in rabbits
Ahad Abdul Rehman, Azra Riaz, Muhammad Arif Asghar, Muhammad Liaquat Raza, Shadab Ahmed & Kamran Khan, 2019 Sep 3, In : BMC Complementary and Alternative Medicine. 19, 1, 236.Research output: Contribution to journal › Article
The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders
Arne Reimers & Hanna Ljung, 2019 Jun 24, In : Therapeutic advances in psychopharmacology. 9Research output: Contribution to journal › Review article
Immune profile in blood following non-convulsive epileptic seizures in rats
Una Avdic, Matilda Ahl, Maria Öberg & Christine T. Ekdahl, 2019 Jan 1, In : Frontiers in Neurology. 10, JUL, 701.Research output: Contribution to journal › Article
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Advancing research toward faster diagnosis, better treatment, and end of stigma in epilepsy
Asla Pitkänen, David C. Henshall, J. Helen Cross, Renzo Guerrini, Sergiusz Jozwiak, Merab Kokaia, Michele Simonato, Sanjay Sisodiya & Janet Mifsud, 2019, In : Epilepsia.Research output: Contribution to journal › Article
Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients
Jenny Wickham, Marco Ledri, Johan Bengzon, Bo Jespersen, Lars H. Pinborg, Elisabet Englund, David P.D. Woldbye, My Andersson & Merab Kokaia, 2019, In : Scientific Reports. 9, 1, 19393.Research output: Contribution to journal › Article
Leaky Optoelectrical Fiber for Optogenetic Stimulation and Electrochemical Detection of Dopamine Exocytosis from Human Dopaminergic Neurons
Shashank Vasudevan, Janko Kajtez, Ada Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martínez-Serrano, Stephan S. Keller & Jenny Emnéus, 2019, In : Advanced Science. 6, 24, 1902011.Research output: Contribution to journal › Article
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Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy
Giovanna Paolone, Chiara Falcicchia, Francesca Lovisari, Merab Kokaia, William J. Bell, Tracie Fradet, Mario Barbieri, Lars U. Wahlberg, Dwaine F. Emerich & Michele Simonato, 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 11, p. 2144-2156 13 p.Research output: Contribution to journal › Article
Physical Activity Reduces Epilepsy Incidence: a Retrospective Cohort Study in Swedish Cross-Country Skiers and an Experimental Study in Seizure-Prone Synapsin II Knockout Mice
Matilda Ahl, Una Avdic, Maria Compagno Strandberg, Deepti Chugh, Emelie Andersson, Ulf Hållmarker, Stefan James, Tomas Deierborg & Christine T. Ekdahl, 2019, In : Sports Medicine - Open. 5, 1, 52.Research output: Contribution to journal › Article
Therapeutic Potential of Iridoid Derivatives: Patent Review.
Muhammad Liaquat Raza, Hidayat Hussain, Ivan R. Green, Muhammad Saleem & Mamona Nazir, 2019, In : Inventions. 4, 2, 29.Research output: Contribution to journal › Review article
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Unilateral ex vivo gene therapy by GDNF in epileptic rats
Avtandil Nanobashvili, Esbjörn Melin, Dwaine Emerich, Jens Tornøe, Michele Simonato, Lars Wahlberg & Merab Kokaia, 2019, In : Gene Therapy. 26, 3-4, p. 65-74Research output: Contribution to journal › Article
- 2018
Prolonged life of human acute hippocampal slices from temporal lobe epilepsy surgery
J. Wickham, N. G. Brödjegård, R. Vighagen, L. H. Pinborg, J. Bengzon, D. P.D. Woldbye, M. Kokaia & M. Andersson, 2018 Dec 1, In : Scientific Reports. 8, 1, 4158.Research output: Contribution to journal › Article
PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity
Julia Adelöf, My Andersson, Michelle Porritt, Anne Petersen, Madeleine Zetterberg, John Wiseman & Malin Hernebring, 2018 Nov 6, In : BMC Neuroscience. 19, 1, 17.Research output: Contribution to journal › Article
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Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain
Idrish Ali, Una Avdic, Deepti Chugh & Christine T. Ekdahl, 2018 Oct 30, In : Cellular and Molecular Immunology. 15, 4, p. 414-417 4 p.Research output: Contribution to journal › Letter
The neuroprotective effects of 17β-estradiol pretreatment in a model of neonatal hippocampal injury induced by trimethyltin
Elisa Marchese, Valentina Corvino, Valentina Di Maria, Alfredo Furno, Stefano Giannetti, Eleonora Cesari, Paola Lulli, Fabrizio Michetti & Maria Concetta Geloso, 2018 Oct 26, In : Frontiers in Cellular Neuroscience. 12, 385.Research output: Contribution to journal › Article
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Test-specific differences in verbal memory assessments used prior to surgery in temporal lobe epilepsy
Hanna Ljung, Maria Compagno Strandberg, Isabella M Björkman-Burtscher, Elia Psouni & Kristina Källén, 2018 Oct, In : Epilepsy and Behavior. 87, p. 18-24 7 p.Research output: Contribution to journal › Article
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Spatiotemporal pattern of Wnt-canonical pathway in dorsal telencephalic organoids.
Ana Gonzalez Ramos, Jonothon Marshall & John O. Mason, 2018 Jul 6, (Unpublished).Research output: Contribution to conference › Poster
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Microscopic diffusion anisotropy reveals microstructural heterogeniety of malformations of cortical development associated with wpilwpsy: a b-tensor encoding study at 7T
Björn Lampinen, Ariadne Zampeli, Filip Szczepankiewicz, MARIA COMPAGNO STRANDBERG, Kristina Källén, Isabella Björkman-Burtscher & Markus Nilsson, 2018 Jun 16.Research output: Contribution to conference › Abstract
Impact of donor chest radiography on clinical outcome after lung transplantation
Gracijela Bozovic, Catharina Adlercreutz, Isabella M Björkman-burtscher, Peter Reinstrup, Richard Ingemansson, Elin Skansebo & Mats Geijer, 2018 May 1, In : Acta Radiologica Open. 7, 6, 7 p.Research output: Contribution to journal › Article
Preserved function of afferent parvalbumin-positive perisomatic inhibitory synapses of dentate granule cells in rapidly kindled mice
Marita G. Hansen, Litsa N. Ledri, Deniz Kirik, Merab Kokaia & Marco Ledri, 2018 Jan 9, In : Frontiers in Cellular Neuroscience. 11, 433.Research output: Contribution to journal › Article
Bridging the gap in translational epilepsy research - A patient brain tissue platform for validating animal data
Jenny Wickham, 2018, Lund: Lund University: Faculty of Medicine. 79 p.Research output: Thesis › Doctoral Thesis (compilation)
Immune responses and synaptic protein expression in epilepsy
Una Avdic, 2018, Lund: Lund University: Faculty of Medicine. 103 p.Research output: Thesis › Doctoral Thesis (compilation)
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Nonconvulsive status epilepticus in rats leads to brain pathology
Una Avdic, Matilda Ahl, Deepti Chugh, Idrish Ali, Karthik Chary, Alejandra Sierra & Christine T. Ekdahl, 2018, In : Epilepsia. 59, 5, p. 945-958Research output: Contribution to journal › Article
Predictors of Verbal Memory Deficits from Temporal Lobe Surgery in Epilepsy. Improving patient selection by investigation of methods used for predicting verbal memory following surgery.
Hanna Ljung, 2018, Lund: Lund University: Faculty of Medicine. 61 p.Research output: Thesis › Doctoral Thesis (compilation)
- 2017
Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
Natalia Avaliani, Ulrich Pfisterer, Andreas Heuer, Malin Parmar, Merab Kokaia & My Andersson, 2017 Nov 26, In : Stem Cells International. 2017, 9 p., 5718608.Research output: Contribution to journal › Article
Altered chloride homeostasis decreases the action potential threshold and increases hyperexcitability in hippocampal neurons
Andreas T. Sørensen, Marco Ledri, Miriam Melis, Litsa Nikitidou Ledri, My Andersson & Merab Kokaia, 2017 Nov 1, In : eNeuro. 4, 6, e0172-17.2017.Research output: Contribution to journal › Article
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Epilepsy and optogenetics: Can seizures be controlled by light?
Jan Tönnesen & Merab Kokaia, 2017 Jul 15, In : Clinical Science. 131, 14, p. 1605-1616 12 p.Research output: Contribution to journal › Review article
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Autoimmunity and mental health in William’s syndrome
Tania Ramos-Moreno, 2017 Jan 1, Advances in Health and Disease. Lowell, D. (ed.). Nova Science Publishers, Inc., Vol. 2. p. 81-114 34 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter
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Common data elements and data management: Remedy to cure underpowered preclinical studies
Niina Lapinlampi, Esbjörn Melin, Eleonora Aronica, Jens P. Bankstahl, Albert Becker, Cristophe Bernard, Jan A. Gorter, Olli Gröhn, Anu Lipsanen, Katarzyna Lukasiuk, Wolfgang Löscher, Jussi Paananen, Teresa Ravizza, Paolo Roncon, Michele Simonato, Annamaria Vezzani, Merab Kokaia & Asla Pitkänen, 2017 Jan 1, In : Epilepsy Research. 129, p. 87-90 4 p.Research output: Contribution to journal › Article
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Impact of generic substitution on levetiracetam serum concentration - a prospective study in an outpatient setting
Patrik Olsson, Arne Reimers, Johanna Nilsson, Elin Hoff, Anders Lundgren, MARIA COMPAGNO STRANDBERG, Margareta Reis & Kristina Kallen, 2017.Research output: Contribution to conference › Abstract
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Toward an Optogenetic Therapy for Epilepsy
Jan Tönnesen, Marco Ledri & Merab Kokaia, 2017, Optogenetics: From Neuronal Function to Mapping and Disease Biology. Appasani, K. (ed.). Cambridge: Cambridge University Press, p. 292-307Research output: Chapter in Book/Report/Conference proceeding › Book chapter
- 2016
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DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue
N. Avaliani, M. Andersson, A. H. Runegaard, D. Woldbye & M. Kokaia, 2016 Oct 1, In : Gene Therapy. 23, 10, p. 760-766 7 p.Research output: Contribution to journal › Article
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Advances in the development of biomarkers for epilepsy
Asla Pitkänen, Wolfgang Löscher, Annamaria Vezzani, Albert J. Becker, Michele Simonato, Katarzyna Lukasiuk, Olli Gröhn, Jens P. Bankstahl, Alon Friedman, Eleonora Aronica, Jan A. Gorter, Teresa Ravizza, Sanjay M. Sisodiya, Merab Kokaia & Heinz Beck, 2016 Jul 1, In : Lancet Neurology. 15, 8, p. 843-856 14 p.Research output: Contribution to journal › Review article
Optogenetic control of human neurons in organotypic brain cultures
My Andersson, Natalia Avaliani, Andreas Svensson, Jenny Wickham, Lars H. Pinborg, Bo Jespersen, Søren H. Christiansen, Johan Bengzon, David P D Woldbye & Merab Kokaia, 2016 Apr 21, In : Scientific Reports. 6, 24818.Research output: Contribution to journal › Article
Novel approaches to explore mechanisms of epileptic seizures - optogenetic and chemogenetic manipulation of hippocampal circuitry
Fredrik Berglind, 2016, Experimental Epilepsy Group. 71 p.Research output: Thesis › Doctoral Thesis (compilation)