MultiPark: Multidisciplinary research focused on Parkinson´s disease

Organisational unit: Strategic research area

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  1. Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study.

    Chouraki, V., Beiser, A., Younkin, L., Preis, S. R., Weinstein, G., Oskar Hansson, Skoog, I., Lambert, J-C., Au, R., Launer, L., Wolf, P. A., Younkin, S. & Seshadri, S., 2015, In : Alzheimer's & Dementia. 11, 3, p. 249-257

    Research output: Contribution to journalArticle

  2. Removing the barriers of plasticity after experimental brain injury

    Jakob Hakon Christensen, 2018, Lund: Lund University: Faculty of Medicine. 66 p.

    Research output: ThesisDoctoral Thesis (compilation)

  3. A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses

    Chtarto, A., Humbert-Claude, M., Bockstael, O., Das, A. T., Boutry, S., Breger, L. S., Klaver, B., Melas, C., Barroso-Chinea, P., Gonzalez-Hernandez, T., Muller, R. N., DeWitte, O., Levivier, M., Cecilia Lundberg, Berkhout, B. & Tenenbaum, L., 2016, In : Molecular therapy. Methods & clinical development. 5, 16027.

    Research output: Contribution to journalArticle

  4. Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease

    Chumarina, M., Carla Azevedo, Bigarreau, J., Vignal, C., Kim, K. S., Jia-Yi Li & Laurent Roybon, 2017 Mar 1, In : Stem Cell Research. 19, p. 17-20 4 p.

    Research output: Contribution to journalArticle

  5. Stem cell-based models to study cellular alterations in Parkinson’s Disease

    Chumarina, M., 2020, Lund: Lund University, Faculty of Medicine. 84 p.

    Research output: ThesisDoctoral Thesis (compilation)

  6. Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease

    Chung, S. J., Biernacka, J. M., Armasu, S. M., Anderson, K., Frigerio, R., Aasly, J. O., Annesi, G., Bentivoglio, A. R., Brighina, L., Chartier-Harlin, M-C., Goldwurm, S., Hadjigeorgiou, G., Jasinska-Myga, B., Jeon, B. S., Kim, Y. J., Krueger, R., Lesage, S., Markopoulou, K., Mellick, G., Morrison, K. E. & 9 others, Andreas Puschmann, Tan, E-K., Crosiers, D., Theuns, J., Van Broeckhoven, C., Wirdefeldt, K., Wszolek, Z. K., Elbaz, A. & Maraganore, D. M., 2014, In : Movement Disorders. 29, 8, p. 1053-1057

    Research output: Contribution to journalArticle

  7. Mutant huntingtin is present in neuronal grafts in Huntington disease patients

    Cicchetti, F., Lacroix, S., Cisbani, G., Vallières, N., Saint-Pierre, M., St-Amour, I., Tolouei, R., Skepper, J. N., Hauser, R. A., Mantovani, D., Barker, R. A. & Freeman, T. B., 2014 Jul, In : Annals of Neurology. 76, 1, p. 31-42 12 p.

    Research output: Contribution to journalArticle

  8. Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

    Cicognola, C., Brinkmalm, G., Wahlgren, J., Portelius, E., Gobom, J., Cullen, N. C., Oskar Hansson, Parnetti, L., Constantinescu, R., Wildsmith, K., Chen, H. H., Beach, T. G., Lashley, T., Zetterberg, H., Blennow, K. & Höglund, K., 2019, In : Acta Neuropathologica. 137, 2, p. 279-296

    Research output: Contribution to journalArticle

  9. Cystamine/cysteamine rescues the dopaminergic system and shows neurorestorative properties in an animal model of Parkinson's disease.

    Cisbani, G., Drouin-Ouellet, J., Gibrat, C., Saint-Pierre, M., Lagacé, M., Badrinarayanan, S., Lavallée-Bourget, M. H., Charest, J., Chabrat, A., Boivin, L., Lebel, M., Bousquet, M., Lévesque, M. & Cicchetti, F., 2015, In : Neurobiology of Disease. 82, p. 430-444

    Research output: Contribution to journalArticle

  10. Management and outcomes following emergency surgery for traumatic brain injury – A multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study)

    Clark, D., Joannides, A., Ibrahim Abdallah, O., Olufemi Adeleye, A., Hafid Bajamal, A., Bashford, T., Bhebhe, A., Biluts, H., Budohoska, N., Budohoski, K., Cherian, I., Marklund, N., Fernandez Mendez, R., Figaji, T., Kumar Gupta, D., Iaccarino, C., Ilunga, A., Joseph, M., Khan, T., Laeke, T. & 19 others, Waran, V., Park, K., Rosseau, G., Rubiano, A., Saleh, Y., Shabani, H. K., Smith, B., Sichizya, K., Tewari, M., Tirsit, A., Thu, M., Tripathi, M., Trivedi, R., Villar, S., Devi Bhagavatula, I., Servadei, F., Menon, D., Kolias, A. & Hutchinson, P., 2020, In : International Journal of Surgery Protocols. 20, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  11. Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

    Clausen, B. H., Degn, M., Martin, N. A., Couch, Y., Karimi, L., Ormhoj, M., Mortensen, M-L. B., Gredal, H. B., Gardiner, C., Sargent, I. I. L., Szymkowski, D. E., Petit, G., Tomas Deierborg, Finsen, B., Anthony, D. C. & Lambertsen, K. L., 2014, In : Journal of Neuroinflammation. 11, 203.

    Research output: Contribution to journalArticle

  12. Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke.

    Clausen, B. H., Lambertsen, K. L., Dagnæs-Hansen, F., Babcock, A. A., von Linstow, C. U., Meldgaard, M., Kristensen, B. W., Tomas Deierborg & Finsen, B., 2016, In : Acta Neuropathologica. 131, 5, p. 775-91

    Research output: Contribution to journalArticle

  13. Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

    Clausen, F., Hånell, A., Israelsson, C., Hedin, J., Ebendal, T., Mir, A. K., Gram, H. & Niklas Marklund, 2011 Jul, In : European Journal of Neuroscience. 34, 1, p. 110-23 14 p.

    Research output: Contribution to journalArticle

  14. Conditional ablation of myeloid TNF increases lesion volume after experimental stroke in mice, possibly via altered ERK1/2 signaling

    Clausen, B. H., Degn, M., Sivasaravanaparan, M., Fogtmann, T., Andersen, M. G., Trojanowsky, M. D., Gao, H., Hvidsten, S., Baun, C., Tomas Deierborg, Finsen, B., Kristensen, B. W., Bak, S. T., Meyer, M., Lee, J., Nedospasov, S. A., Brambilla, R. & Lambertsen, K. L., 2016 Jul 7, In : Scientific Reports. 6, 29291.

    Research output: Contribution to journalArticle

  15. Fumarate decreases edema volume and improves functional outcome after experimental stroke

    Clausen, B. H., Lundberg, L., Yli-Karjanmaa, M., Martin, N. A., Martina Svensson, Alfsen, M. Z., Flæng, S. B., Lyngsø, K., Antonio Boza-Serrano, Nielsen, H. H., Hansen, P. B., Finsen, B., Tomas Deierborg, Illes, Z. & Lambertsen, K. L., 2017 Sep 1, In : Experimental Neurology. 295, p. 144-154 11 p.

    Research output: Contribution to journalArticle

  16. Interstitial F(2)-isoprostane 8-iso-PGF(2α) as a biomarker of oxidative stress after severe human traumatic brain injury

    Clausen, F., Niklas Marklund, Lewén, A., Enblad, P., Basu, S. & Hillered, L., 2012 Mar 20, In : Journal of Neurotrauma. 29, 5, p. 766-75

    Research output: Contribution to journalArticle

  17. The Fluid Percussion Injury Rodent Model in Preclinical Research on Traumatic Brain Injury

    Clausen, F., Hillered, L. & Niklas Marklund, 2019 Jan 1, Animal Models of Neurotrauma. Risling, M. & Davidsson, J. (eds.). Humana Press, p. 3-18 16 p. (Neuromethods; vol. 149).

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  18. Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation

    Clayton, E. L., Mancuso, R., Tolstrup Nielsen, T., Mizielinska, S., Holmes, H., Powell, N., Norona, F., Overgaard Larsen, J., Milioto, C., Wilson, K. M., Lythgoe, M. F., Ourselin, S., Nielsen, J. E., Johannsen, P., Holm, I., Collinge, J., Oliver, P. L., Gomez-Nicola, D., Isaacs, A. M., Englund, E. & 1 others, FReJA, 2017 Mar 1, In : Human Molecular Genetics. 26, 5, p. 873-887

    Research output: Contribution to journalArticle

  19. Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment

    Clerx, L., van Rossum, I. A., Burns, L., Knol, D. L., Scheltens, P., Verhey, F., Aalten, P., Lapuerta, P., van de Pol, L., van Schijndel, R., de Jong, R., Barkhof, F., Wolz, R., Rueckert, D., Bocchetta, M., Tsolaki, M., Nobili, F., Wahlund, L-O., Minthon, L., Froelich, L. & 3 others, Hampel, H., Soininen, H. & Visser, P. J., 2013, In : Neurobiology of Aging. 34, 8, p. 2003-2013

    Research output: Contribution to journalArticle

  20. Proliferation of amyloid-beta 42 aggregates occurs through a secondary nucleation mechanism

    Cohen, S. I. A., Sara Linse, Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D. E., Vendruscolo, M., Dobson, C. M. & Knowles, T. P. J., 2013, In : Proceedings of the National Academy of Sciences. 110, 24, p. 9758-9763

    Research output: Contribution to journalArticle

  21. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

    Cohen, S. I. A., Cukalevski, R., Michaels, T. C. T., Šarić, A., Mattias Törnquist, Vendruscolo, M., Dobson, C. M., Buell, A. K., Knowles, T. P. J. & Sara Linse, 2018 May 1, In : Nature Chemistry. 10, 5, p. 523-531 9 p.

    Research output: Contribution to journalArticle

  22. Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease

    Collins, L. M., Begeti, F., Panin, F., Lazar, A. S., Cruickshank, T., Ziman, M., Mason, S. L. & Barker, R. A., 2015 Sep 8, In : PLoS Currents. 7

    Research output: Contribution to journalArticle

  23. A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington's disease

    Collins, L. M., Lazic, S. E. & Barker, R. A., 2014 Feb 24, In : BMC Neurology. 14, 35.

    Research output: Contribution to journalArticle