Stem Cell Center

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  1. The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation.

    Acosta, H., Iliev, D., Hooi Min Tan Grahn, Gouignard, N., Marco Maccarana, Griesbach, J., Herzmann, S., Sagha, M., Climent, M. & Edgar Pera, 2015, In : Development. 142, 6, p. 1146-1158

    Research output: Contribution to journalArticle

  2. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

    Adewumi, O., Aflatoonian, B., Ahrlund-Richter, L., Amit, M., Andrews, P. W., Beighton, G., Bello, P. A., Benvenisty, N., Berry, L. S., Bevan, S., Blum, B., Brooking, J., Chen, K. G., Choo, A. B. H., Churchill, G. A., Corbel, M., Damjanov, I., Draper, J. S., Dvorak, P., Emanuelsson, K. & 65 othersFleck, R. A., Ford, A., Gertow, K., Gertsenstein, M., Gokhale, P. J., Hamilton, R. S., Hampl, A., Healy, L. E., Hovatta, O., Hyllner, J., Imreh, M. P., Itskovitz-Eldor, J., Jackson, J., Johnson, J. L., Jones, M., Kee, K., King, B. L., Knowles, B. B., Lako, M., Lebrin, F., Mallon, B. S., Manning, D., Mayshar, Y., Mckay, R. D. G., Michalska, A. E., Mikkola, M., Mileikovsky, M., Minger, S. L., Moore, H. D., Mummery, C. L., Nagy, A., Nakatsuji, N., O'Brien, C. M., Oh, S. K. W., Olsson, C., Otonkoski, T., Park, K-Y., Passier, R., Patel, H., Patel, M., Pedersen, R., Pera, M. F., Piekarczyk, M. S., Pera, R. A. R., Reubinoff, B. E., Robins, A. J., Rossant, J., Rugg-Gunn, P., Schulz, T. C., Semb, H., Sherrer, E. S., Siemen, H., Stacey, G. N., Stojkovic, M., Suemori, H., Szatkiewicz, J., Turetsky, T., Tuuri, T., van den Brink, S., Vintersten, K., Vuoristo, S., Ward, D., Weaver, T. A., Young, L. A. & Zhang, W., 2007, In : Nature Biotechnology. 25, 7, p. 803-816

    Research output: Contribution to journalArticle

  3. Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity

    Adolfsson, J., Borge, O. J., David Bryder, Theilgaard-Monch, K., Åstrand-Grundström, I., Ewa Sitnicka Quinn, Sasaki, Y. & Jacobsen, S. E. W., 2001, In : Immunity. 15, 4, p. 659-669

    Research output: Contribution to journalArticle

  4. Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment

    Adolfsson, J., Månsson, R., Buza-Vidas, N., Anne Hultquist, Liuba, K., Christina Jensen, David Bryder, Yang, L., Borge, OJ., Thorén, L., Anderson, K., Ewa Sitnicka Quinn, Sasaki, Y., Mikael Sigvardsson & Jacobsen, S. E. W., 2005, In : Cell. 121, 2, p. 295-306

    Research output: Contribution to journalArticle

  5. Expression and role of the cytokine tyrosine kinase receptor flt3 in early hematopoiesis

    Adolfsson, J., 2004, Jörgen Adolfsson, Stem Cell Laboratory, BMC B10, Klinikg 26, 22184 Lund. 180 p.

    Research output: ThesisDoctoral Thesis (compilation)

  6. Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies

    Agathangelidis, A., Darzentas, N., Hadzidimitriou, A., Brochet, X., Murray, F., Yan, X-J., Davis, Z., van Gastel-Mol, E. J., Tresoldi, C., Chu, C. C., Cahill, N., Giudicelli, V., Tichy, B., Pedersen, L. B., Foroni, L., Bonello, L., Janus, A., Smedby, K., Anagnostopoulos, A., Merle-Beral, H. & 16 othersLaoutaris, N., Gunnar Juliusson, di Celle, P. F., Pospisilova, S., Jurlander, J., Geisler, C., Tsaftaris, A., Lefranc, M-P., Langerak, A. W., Oscier, D. G., Chiorazzi, N., Belessi, C., Davi, F., Rosenquist, R., Ghia, P. & Stamatopoulos, K., 2012, In : Blood. 119, 19, p. 4467-4475

    Research output: Contribution to journalArticle

  7. Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

    Helena Ågerstam, Christine Karlsson, Hansen, N., Carl Sandén, Askmyr, M., Sofia von Palffy, Högberg, C., Rissler, M., Wunderlich, M., Gunnar Juliusson, Johan Richter, Sjöström, K., Bhatia, R., Mulloy, J. C., Marcus Järås & Thoas Fioretos, 2015, In : Proceedings of the National Academy of Sciences. 112, 34, p. 10786-10791

    Research output: Contribution to journalArticle

  8. IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models

    Helena Ågerstam, Hansen, N., Sofia von Palffy, Carl Sandén, Reckzeh, K., Christine Karlsson, Henrik Lilljebjörn, Niklas Landberg, Askmyr, M., Högberg, C., Rissler, M., Porkka, K., Wadenvik, H., Mustjoki, S., Johan Richter, Marcus Järås & Thoas Fioretos, 2016 Dec 8, In : Blood. 128, 23, p. 2683-2693

    Research output: Contribution to journalArticle

  9. Adaptor Protein LNK Is a Negative Regulator of Brain Neural Stem Cell Proliferation after Stroke.

    Henrik Ahlenius, Devaraju, K., Emanuela Monni, Oki, K., Wattananit, S., Darsalia, V., Iosif, R., Torper, O., Wood, J., Sebastian Braun, Jagemann, L., Nuber, U., Elisabet Englund, Jacobsen, S. E. W., Olle Lindvall & Zaal Kokaia, 2012, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 32, 15, p. 5151-5164

    Research output: Contribution to journalArticle

  10. Mesenchymal stem cell content of human vertebral bone marrow

    Ahrens, N., Tormin, A., Paulus, M., Roosterman, D., Salama, A., Krenn, V., Neumann, U. & Stefan Scheding, 2004, In : Transplantation. 78, 6, p. 925-929

    Research output: Contribution to journalArticle

  11. Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

    Ajmone-Cat, M. A., Onori, A., Toselli, C., Stronati, E., Morlando, M., Bozzoni, I., Emanuela Monni, Zaal Kokaia, Lupo, G., Minghetti, L., Biagioni, S. & Cacci, E., 2019 Mar 14, In : Scientific Reports. 9, 1, 4572.

    Research output: Contribution to journalArticle

  12. Gene expression analysis suggests that EBF-1 and PPAR gamma 2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics

    Akerblad, P., Månsson, R., Lagergren, A., Westerlund, S., Basta, B., Lind, U., Thelin, A., Gisler, R., Liberg, D., Nelander, S., Bamberg, K. & Mikael Sigvardsson, 2005, In : Physiological Genomics. 23, 2, p. 206-216

    Research output: Contribution to journalArticle

  13. Early B-cell factor (o/e-1) is a promoter of adipogenesis and involved in control of genes important for terminal adipocyte differentiation.

    Åkerblad, P., Lind, U., Liberg, D., Bamberg, K. & Mikael Sigvardsson, 2002, In : Molecular and Cellular Biology. 22, 22, p. 8015-8025

    Research output: Contribution to journalArticle

  14. FGF signaling in specification of hESC-derived definitive endoderm

    Ameri, J., 2010, Stem Cells and Pancreas Development Biology. 91 p.

    Research output: ThesisDoctoral Thesis (compilation)

  15. FGF2 Specifies hESC-Derived Definitive Endoderm into Foregut/Midgut Cell Lineages in a Concentration-Dependent Manner.

    Ameri, J., Ståhlberg, A., Pedersen, J., Johansson, J., Johannesson, M., Isabella Artner & Semb, H., 2010, In : Stem Cells. 28, p. 45-56

    Research output: Contribution to journalArticle

  16. Efficient Generation of Glucose-Responsive Beta Cells from Isolated GP2+ Human Pancreatic Progenitors

    Ameri, J., Borup, R., Prawiro, C., Ramond, C., Schachter, K. A., Scharfmann, R. & Semb, H., 2017 Apr 4, In : Cell Reports. 19, 1, p. 36-49 14 p.

    Research output: Contribution to journalArticle

  17. Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes.

    Anderson, K., Rusterholz, C., Månsson, R., Christina Jensen, Karl Bacos, Zandi, S., Sasaki, Y., Nerlov, C., Mikael Sigvardsson & Jacobsen, S. E. W., 2007, In : Blood. 109, Jan 11, p. 3697-3705

    Research output: Contribution to journalArticle

  18. Fluorescence in situ hybridization for the study of cell lineage involvement in myelodysplastic syndromes with chromosome 5 anomalies

    Anderson, K., Arvidsson, I., Jacobsson, J. & Hast, R., 2002, In : Cancer Genetics and Cytogenetics. 136, 2, p. 101-107

    Research output: Contribution to journalArticle

  19. Cellular pathways and molecular regulation of hematopoietic stem cells

    Anderson, K., 2007, Hematopoietic Stem Cell Laboratory. 2001 p.

    Research output: ThesisDoctoral Thesis (compilation)

  20. The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response

    Andersson, M. K., Stahlberg, A., Arvidsson, Y., Olofsson, A., Semb, H., Stenman, G., Nilsson, O. & Aman, P., 2008, In : BMC Cell Biology. 9, 37.

    Research output: Contribution to journalArticle

  21. Management of patients with polycythaemia vera: results of a survey among Swedish haematologists

    Andreasson, B., Lofvenberg, E. & Westin, J., 2005, In : European Journal of Haematology. 74, 6, p. 489-495

    Research output: Contribution to journalArticle

  22. The International Stem Cell initiative: toward benchmarks for human embryonic stem cell research

    Andrews, P. W., Benvenisty, N., McKay, R., Pera, M. F., Rossant, J., Semb, H. & Stacey, G. N., 2005, In : Nature Biotechnology. 23, 7, p. 795-797

    Research output: Contribution to journalArticle

  23. Decreased inducibility of TNF expression in lipid-loaded macrophages.

    Ares, M., Stollenwerk, M., Olsson, A., Kallin, B., Jovinge, S. & Jan Nilsson, 2002, In : BMC Immunology. 3, 1, p. 13-13

    Research output: Contribution to journalArticle

  24. Retinol dehydrogenase-10 regulates pancreas organogenesis and endocrine cell differentiation via paracrine retinoic acid signaling

    Arregi, I., Climent, M., Iliev, D., Strasser, J., Gouignard, N., Johansson, J. K., Tania Singh, Mazur, M., Semb, H., Isabella Artner, Minichiello, L. & Edgar M. Pera, 2016 Dec 1, In : Endocrinology. 157, 12, p. 4615-4631 17 p.

    Research output: Contribution to journalArticle

  25. MafA and MafB Regulate Genes Critical to beta-Cells in a Unique Temporal Manner

    Isabella Artner, Hang, Y., Mazur, M., Yamamoto, T., Guo, M., Lindner, J., Magnuson, M. A. & Stein, R., 2010, In : Diabetes. 59, 10, p. 2530-2539

    Research output: Contribution to journalArticle

  26. MaFA is a dedicated activator of the insulin gene in vivo.

    Isabella Artner, Hang, Y., Guo, M., Gu, G. & Stein, R., 2008, In : Journal of Endocrinology. May 30, p. 271-279

    Research output: Contribution to journalArticle

  27. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

    Askmyr, M., Helena Ågerstam, Hansen, N., Gordon, S., Alexandros Arvanitakis, Rissler, M., Gunnar Juliusson, Johan Richter, Marcus Järås & Thoas Fioretos, 2013, In : Blood. 121, 18, p. 3709-3713

    Research output: Contribution to journalArticle

  28. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

    Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M. & 9 othersJ D Johnson, C B Wollheim, Derry, J. M. J., Mecham, B., P Spégel, H Mulder, Costa, I. G., E Zhang & Rosengren, A. H., 2017 Jun 6, In : Nature Communications. 8, p. 15652

    Research output: Contribution to journalArticle

  29. HemaExplorer: a Web server for easy and fast visualization of gene expression in normal and malignant hematopoiesis

    Bagger, F. O., Rapin, N., Theilgaard-Moench, K., Kaczkowski, B., Jendholm, J., Winther, O. & Porse, B., 2012, In : Blood. 119, 26, p. 6394-6395

    Research output: Contribution to journalLetter

  30. HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis.

    Bagger, F. O., Rapin, N., Theilgaard-Moench, K., Kaczkowski, B., Thorén, L., Jendholm, J., Winther, O. & Porse, B. T., 2013, In : Nucleic Acids Research. 41, D1, p. D1034-D1039

    Research output: Contribution to journalArticle

  31. Recurrent mutations refine prognosis in chronic lymphocytic leukemia.

    Baliakas, P., Hadzidimitriou, A., Sutton, L-A., Rossi, D., Minga, E., Villamor, N., Larrayoz, M., Kminkova, J., Agathangelidis, A., Davis, Z., Tausch, E., Stalika, E., Kantorova, B., Mansouri, L., Scarfò, L., Cortese, D., Navrkalova, V., Rose-Zerilli, M. J. J., Smedby, K. E., Juliusson, G. & 14 othersAnagnostopoulos, A., Makris, A. M., Navarro, A., Delgado, J., Oscier, D., Belessi, C., Stilgenbauer, S., Ghia, P., Pospisilova, S., Gaidano, G., Campo, E., Strefford, J. C., Stamatopoulos, K. & Rosenquist, R., 2015, In : Leukemia. 29, 2, p. 329-336

    Research output: Contribution to journalArticle

  32. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.

    Baliakas, P., Agathangelidis, A., Hadzidimitriou, A., Sutton, L-A., Minga, E., Tsanousa, A., Scarfò, L., Davis, Z., Yan, X-J., Shanafelt, T., Plevova, K., Sandberg, Y., Vojdeman, F. J., Boudjogra, M., Tzenou, T., Chatzouli, M., Chu, C. C., Veronese, S., Gardiner, A., Mansouri, L. & 28 othersSmedby, K. E., Pedersen, L. B., Moreno, D., Van Lom, K., Giudicelli, V., Francova, H. S., Nguyen-Khac, F., Panagiotidis, P., Gunnar Juliusson, Angelis, L., Anagnostopoulos, A., Lefranc, M-P., Facco, M., Trentin, L., Catherwood, M., Montillo, M., Geisler, C. H., Langerak, A. W., Pospisilova, S., Chiorazzi, N., Oscier, D., Jelinek, D. F., Darzentas, N., Belessi, C., Davi, F., Ghia, P., Rosenquist, R. & Stamatopoulos, K., 2015, In : Blood. 125, 5, p. 856-859

    Research output: Contribution to journalArticle

  33. Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study

    Baliakas, P., Hadzidimitriou, A., Sutton, L-A., Minga, E., Agathangelidis, A., Nichelatti, M., Tsanousa, A., Scarfo, L., Davis, Z., Yan, X-J., Shanafelt, T., Plevova, K., Sandberg, Y., Vojdeman, F. J., Boudjogra, M., Tzenou, T., Chatzouli, M., Chu, C. C., Veronese, S., Gardiner, A. & 28 othersMansouri, L., Smedby, K. E., Pedersen, L. B., van Lom, K., Giudicelli, V., Francova, H. S., Nguyen-Khac, F., Panagiotidis, P., Gunnar Juliusson, Angelis, L., Anagnostopoulos, A., Lefranc, M-P., Facco, M., Trentin, L., Catherwood, M., Montillo, M., Geisler, C. H., Langerak, A. W., Pospisilova, S., Chiorazzi, N., Oscier, D., Jelinek, D. F., Darzentas, N., Belessi, C., Davi, F., Rosenquist, R., Ghia, P. & Stamatopoulos, K., 2014, In : Lancet Haematology. 1, 2, p. E74-E84

    Research output: Contribution to journalArticle

  34. No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(Immuno)therapy

    Baliakas, P., Mattsson, M., Hadzidimitriou, A., Minga, E., Agathangelidis, A., Sutton, L. A., Scarfo, L., Davis, Z., Yan, X. J., Plevova, K., Sandberg, Y., Vojdeman, F. J., Tzenou, T., Chu, C. C., Veronese, S., Mansouri, L., Smedby, K. E., Giudicelli, V., Nguyen-Khac, F., Panagiotidis, P. & 20 othersGunnar Juliusson, Anagnostopoulos, A., Lefranc, M. P., Trentin, L., Catherwood, M., Montillo, M., Niemann, C. U., Langerak, A. W., Pospisilova, S., Stavroyianni, N., Chiorazzi, N., Oscier, D., Jelinek, D. F., Shanafelt, T., Darzentas, N., Belessi, C., Davi, F., Ghia, P., Rosenquist, R. & Stamatopoulos, K., 2018 Mar 23, In : Haematologica. 103, 4, p. e158-e161

    Research output: Contribution to journalLetter

  35. Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement.

    Bardini, M., Woll, P. S., Corral, L., Luc, S., Wittmann, L., Ma, Z., Lo Nigro, L., Basso, G., Biondi, A., Cazzaniga, G. & Jacobsen, S. E. W., 2015, In : Leukemia. 29, 1, p. 38-50

    Research output: Contribution to journalArticle

  36. In Infant ALL with t(4;11)/MLL-AF4 Multiple and Phenotypically Distinct CD19+BM Subsets Initiate Leukemia in NOD/SCID Mice

    Bardini, M., Wittmann, L., Corral, L., Lo Nigro, L., Ma, Z., Singh, R., Basso, G., De Rossi, G., Greaves, M., Biondi, A., Cazzaniga, G. & Jacobsen, S. E. W., 2009, In : Blood. 114, 22, p. 582-582

    Research output: Contribution to journalPublished meeting abstract

  37. In infant all with T(4;11)/MLL-AF4 multiple and phenotypically distinct BM subsets initiate leukemia into NOD/SCID mice

    Bardini, M., Wittmann, L., Corral, L., Ma, Z., Biondi, A., Singh, R., Cazzaniga, G. & Jacobsen, S. E. W., 2009, In : Experimental Hematology. 37, 9, p. S49-S49

    Research output: Contribution to journalPublished meeting abstract

  38. Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

    Barker, R. A., Malin Parmar, Agnete Kirkeby, Anders Björklund, Thompson, L. & Brundin, P., 2016, In : Journal of Parkinson's Disease. 6, 1, p. 57-63 7 p.

    Research output: Contribution to journalArticle

  39. Insamling av navelsträngsblod bör finansieras offentligt

    Békássy, A., Ringden, O., Gunnar Juliusson & Winiarski, J., 2005, In : Läkartidningen. 102, 1-2, p. 64-64

    Research output: Contribution to journalLetter

  40. Does Low-Molecular-Weight Heparin Influence the Antimyeloma Effects of Thalidomide? A Retrospective Analysis of Data from the GIMEMA, Nordic and Turkish Myeloma Study Groups

    Beksac, M., Waage, A., Bringhen, S., Kristinsson, S. Y., Sucak, G. T., Gimsing, P., Lupparelli, G., Firatli-Tuglular, T., Gunnar Juliusson, Ingemar Turesson & Palumbo, A., 2015, In : Acta Haematologica. 133, 4, p. 372-380

    Research output: Contribution to journalArticle

  41. Lack of the Cysteine-Protease Inhibitor Cystatin C Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice.

    Eva Bengtsson, To, F., Håkansson, K., Anders Grubb, Brånén, L., Jan Nilsson & Jovinge, S., 2005, In : Arteriosclerosis, Thrombosis and Vascular Biology. 25, 10, p. 2151-2156

    Research output: Contribution to journalArticle

  42. Absence of the protease inhibitor cystatin C in inflammatory cells results in larger plaque area in plaque regression of apoE-deficient mice.

    Eva Bengtsson, To, F., Anders Grubb, Håkansson, K., Wittgren, L., Jan Nilsson & Jovinge, S., 2005, In : Atherosclerosis. 180, 1, p. 45-53

    Research output: Contribution to journalArticle

  43. Quantification of mRNA in single cells and modelling of RT-qPCR induced noise

    Bengtsson, M., Hemberg, M., Rorsman, P. & Stålberg, A., 2008, In : BMC Molecular Biology. 9, 63

    Research output: Contribution to journalArticle

  44. Cystatin C and cathepsins in cardiovascular disease.

    Eva Bengtsson, Jan Nilsson & Jovinge, S., 2008, In : Frontiers in Bioscience. 13, 1, p. 5780-5786

    Research output: Contribution to journalArticle

  45. Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

    Bennet, H., Mollet, I., Balhuizen, A., Medina Benavente, A., Nagorny, C., Bagge, A., Fadista, J., Ottosson Laakso, E., Petter Vikman, Dekker Nitert, M., Lena Eliasson, Nils Wierup, Isabella Artner & Malin Fex, 2016, In : Diabetologia. 59, 4, p. 744-754

    Research output: Contribution to journalArticle

  46. Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBP alpha Mutant AML

    Bereshchenko, O., Mancini, E., Moore, S., Bilbao, D., Månsson, R., Luc, S., Grover, A., Jacobsen, S. E. W., David Bryder & Nerlov, C., 2009, In : Cancer Cell. 16, 5, p. 390-400

    Research output: Contribution to journalArticle

  47. Satisfactory outcome after intensive chemotherapy with pragmatic use of minimal residual disease (MRD) monitoring in older patients with Philadelphia-negative B cell precursor acute lymphoblastic leukaemia: a Swedish registry-based study

    Bergfelt, E., Kozlowski, P., Ahlberg, L., Hulegardh, E., Hagglund, H., Karlsson, K., Markuszewska-Kuczymska, A., Tomaszewska-Toporska, B., Smedmyr, B., Astrom, M., Amini, R-M. & Hallbook, H., 2015, In : Medical Oncology. 32, 4, p. 135

    Research output: Contribution to journalArticle

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