Anders P Hakansson

Professor, Research Fellow, Children's Hospital Boston, HMS, Boston, MA, Research Fellow, Brigham and Women's Hospital, HMS, Boston, MA, Post-doc, Univeristy of Alabama at Birmingham, Birmingham, AL, Assistant Professor of Microbiology and Immunology, Univeristy at Buffalo, Buffalo, NY, PhD, B. MedFormer name: Anders HakanssonFormer name: Anders Håkansson

Research areas and keywords

UKÄ subject classification

  • Microbiology in the medical area
  • Immunology in the medical area
  • Infectious Medicine
  • Microbiology
  • Immunology
  • Biochemistry and Molecular Biology

Keywords

  • Host-pathogen interactions, Bacteria, Streptococci, Staphylococci, Biofilms, Respiratory disease, Otitis media, Pneumonia, Sepsis, Virus infection, Vaccines, Inflammation, Antibiotics, Antibiotic resistance, Human milk, Protein, Drug development, Infections

Research

Our laboratory are focused on understanding host-pathogen interactions, with emphasis on respiratory pathogens, and to use this knowledge to develop novel preventive and therapeutic strategies to protect against bacterial infection. Our work focuses on both the factors used by bacteria to establish colonization and cause disease and how this is counteracted by the host inflammatory response to colonization and infection. The main research projects in the laboratory are:

(A) The study of biofilm formation during bacterial colonization, the role of biofilm formation and colonization for optimal transformation and genetic exchange, and the mechanisms of transition from colonization to infection;

(B) Applying the information from our pathogenesis studies to develop novel strategies to protect individuals against upper respiratory tract infection (pneumonia and otitis media) through immunization; and

(C) The study of the direct bactericidal activity of a human milk protein-lipid complex (HAMLET, human alpha-lactalbumin made lethal to tumor cells) against various bacterial species as well as develop its adjuvant activity in sensitizing bacteria to a broad range of common antibiotics to provide novel therapeutic strategies against respiratory and other infections with antibiotic-resistant bacteria.

Highlighted research outputs

Anders P Hakansson, Marks, L. R. & Roche-Hakansson, H., 2015 Jan 1, Streptococcus pneumoniae: Molecular mechanisms of host-pathogen interactions. Orihuela, C., Hammerschmidt, S. & Brown, J. (eds.). London: Elsevier Limited, p. 129-142 14 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Yashuan Chao, Caroline Bergenfelz & Anders P Hakansson, 2019, Streptococcus pneumoniae: Methods and Protocols. Humana Press, Vol. 1968. p. 147-171 (Methods in molecular biology (Clifton, N.J.)).

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Meikle, V., Mossberg, A-K., Mitra, A., Anders P Hakansson & Niederweis, M., 2019 Feb 1, In : Antimicrobial Agents and Chemotherapy. 63, 2, e01846-18.

Research output: Contribution to journalArticle

A. P. Hakansson, Orihuela, C. J. & Bogaert, D., 2018 Apr, In : Physiological Reviews. 98, 2, p. 781-811 31 p.

Research output: Contribution to journalReview article

Yashuan Chao, Caroline Bergenfelz & Anders P. Håkansson, 2017, Methods in Molecular Biology. Humana Press, Vol. 1535. p. 285-299 15 p. (Methods in Molecular Biology; vol. 1535).

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Li, Y., Hill, A., Beitelshees, M., Shao, S., Lovell, J. F., Davidson, B. A., Knight, P. R., Anders P Hakansson, Pfeifer, B. A. & Jones, C. H., 2016 Jun 21, In : Proceedings of the National Academy of Sciences. 113, 25, p. 6898-6903 6 p.

Research output: Contribution to journalArticle

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