Anja Meissner

Associate Senior Lecturer, PhD, Dipl. Troph.

Research areas and keywords

UKÄ subject classification

  • Physiology
  • Cell and Molecular Biology
  • Immunology in the medical area

Keywords

  • Vascular Function, Cardiovascular Diseases, Vascular Dementia, Sphingosine-1-phosphate signaling, Inflammation

Research

Cardiovascular disease such as heart attack, stroke, and peripheral vascular disease, is the number-one health problem in the world. Despite remarkable progress in diagnosis and prevention, cardiovascular diseases cause disability and death at an astounding rate. The best opportunities to develop and implement new strategies for preventing and treating cardiovascular disease lies in the understanding of its underlying mechanisms. Our research aims to isolate novel therapeutic targets that effectively prevent and most importantly, also reverse complications mediated by cardiovascular risk factors such as hypertension.

Specifically, we are interested in sphingosine-1-phosphate (S1P) signaling and its role in the regulation of the vascular and the immune system. We recently described a novel role for S1P and its generating enzyme SphK2 in the pathogenesis of experimental hypertension, whereby hematopoietic Sphk2 activity crucially regulates the hypertension-induced elevation of plasma S1P. Remarkably, elevated plasma S1P levels have also been reported in human hypertension. Thus far, our earlier work provides ample evidence that S1P plays a key role in immune cell recruitment, cytokine production and vascular tone regulation during experimental hypertension and heart failure. Therefore, we strongly believe that its signaling axis will prove to be an attractive therapeutic target in cardiovascular complications.

 

 

Recent research outputs

Munk, A. S., Wang, W., Nicholas Burdon Bèchet, Eltanahy, A. M., Cheng, A. X., Sigurdsson, B., Benraiss, A., Mäe, M. A., Kress, B. T., Kelley, D. H., Betsholtz, C., Møllgård, K., Anja Meissner, Nedergaard, M. & Iben Lundgaard, 2019, In : Cell Reports. p. 2955-2969.e3

Research output: Contribution to journalArticle

Salas Perdomo, A., Miro, F., Gallizioli, M., Brait, V., Justizia, C., Anja Meissner, Urra, X., Chamorro, A. & Planas, A. M., 2019, In : Scientific Reports. 9, 1, 8309.

Research output: Contribution to journalArticle

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