Anna Darabi

Researcher, PhD, Ass. Professor, Associate Professor, Doctor of Philosophy, University degree of Masters of Science, University certificate in Biomedical Laboratory ScienceFormer name: Anna C Johansson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology
  • Immunology in the medical area
  • Pediatrics

Keywords

  • Brain tumor, Immunotherapy, Medulloblastoma, Pediatric brain tumor, Inflammation

Research

Brain tumors represent 1/4 of all cancers in children. Although ca. 50% are cured, the long-term side effects of current therapy are significant. Immunotherapy has proven effective in experimental brain tumor models and several clinical trials have been initiated. Most tumors, including brain tumors in children, contain not only tumor cells, but also various types of immune cells and other stromal cells. These cells interact with tumor cells, via common signaling, and induce inflammation and immunosuppression locally in the tumor, but also systemically. Our research is focused on investigating how the immune system can be modulated from tumor-promoting conditions to a state where the immune system instead helps to reject tumors. We are also working to develop good model systems that represent different types of childhood brain tumors, as there is currently strong demand for such models. These models can be used to answer how tumors respond to new cancer treatments, how current treatment works in tune with new treatments, and provide detailed knowledge of specific interactions between the tumor and surrounding cells.

Highlighted research outputs

Emma Sandén, Julio Enríquez Pérez, Edward Visse, Marcel Kool, Helena Carén, Peter Siesjö & Anna Darabi, 2016 Dec, In: Pediatric Blood & Cancer. 63, 12, p. 2112-2122

Research output: Contribution to journalArticle

Emma Sandén, Cecilia Dyberg, Cecilia Krona, Edward Visse, Helena Carén, Paul A Northcott, Marcel Kool, Nils Ståhl, Annette Persson, Elisabet Englund, John I Johnsen, Peter Siesjö & Anna Darabi, 2015, In: Journal of Neuro-Oncology. 123, 1, p. 1-13

Research output: Contribution to journalArticle

Malin Wickström, Cecilia Dyberg, Jelena Milosevic, Christer Einvik, Raul Calero, Baldur Sveinbjörnsson, Emma Sandén, Anna Darabi, Peter Siesjö, Marcel Kool, Per Kogner, Ninib Baryawno & John Inge Johnsen, 2015, In: Nature Communications. 6, 8904.

Research output: Contribution to journalArticle

Paul A Northcott, Catherine Lee, Thomas Zichner, Adrian M Stütz, Serap Erkek, Daisuke Kawauchi, David J H Shih, Volker Hovestadt, Marc Zapatka, Dominik Sturm, David T W Jones, Marcel Kool, Marc Remke, Florence M G Cavalli, Scott Zuyderduyn, Gary D Bader, Scott VandenBerg, Lourdes Adriana Esparza, Marina Ryzhova, Wei Wang & 59 others, Andrea Wittmann, Sebastian Stark, Laura Sieber, Huriye Seker-Cin, Linda Linke, Fabian Kratochwil, Natalie Jäger, Ivo Buchhalter, Charles D Imbusch, Gideon Zipprich, Benjamin Raeder, Sabine Schmidt, Nicolle Diessl, Stephan Wolf, Stefan Wiemann, Benedikt Brors, Chris Lawerenz, Jürgen Eils, Hans-Jörg Warnatz, Thomas Risch, Marie-Laure Yaspo, Ursula D Weber, Cynthia C Bartholomae, Christof von Kalle, Eszter Turányi, Peter Hauser, Emma Sandén, Anna Darabi, Peter Siesjö, Jaroslav Sterba, Karel Zitterbart, David Sumerauer, Peter van Sluis, Rogier Versteeg, Richard Volckmann, Jan Koster, Martin U Schuhmann, Martin Ebinger, H Leighton Grimes, Giles W Robinson, Amar Gajjar, Martin Mynarek, Katja von Hoff, Stefan Rutkowski, Torsten Pietsch, Wolfram Scheurlen, Jörg Felsberg, Guido Reifenberger, Andreas E Kulozik, Andreas von Deimling, Olaf Witt, Roland Eils, Richard J Gilbertson, Andrey Korshunov, Michael D Taylor, Peter Lichter, Jan O Korbel, Robert J Wechsler-Reya & Stefan M Pfister, 2014, In: Nature. 511, 7510, p. 428

Research output: Contribution to journalArticle

Sofia Eberstål, Emma Sandén, Sara Fritzell, Anna Darabi, Edward Visse & Peter Siesjö, 2014, In: International Journal of Cancer. 134, 11, p. 2748-2753

Research output: Contribution to journalArticle

Sara Fritzell, Emma Sandén, Sofia Eberstål, Edward Visse, Anna Darabi & Peter Siesjö, 2013, In: Cancer Immunology and Immunotherapy. 62, 9, p. 1463-1474

Research output: Contribution to journalArticle

Sofia Eberstål, Wiaam Badn, Sara Fritzell, Magnus Esbjörnsson, Anna Darabi, Edward Visse & Peter Siesjö, 2012, In: Cancer immunology, immunotherapy : CII. 61, 8, p. 1191-1199

Research output: Contribution to journalArticle

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