Anna Hagström

Senior Lecturer, Principal InvestigatorFormer name: Anna AnderssonKnown as name: Anna Hagström-Andersson

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Leukemia, MLL, Mouse models

Research

Acute leukemia in infants (less than one year of age) is characterized by rearrangements of the Mixed Lineage Leukemia (MLL) gene (MLL-R) and a very poor survival. MLL-R leukemia can also be found in children above one year of age; these typically have a better survival. Thus, new therapeutic approaches are needed to improve the cure rates for these patients, in particular for infant ALL.

My research efforts focus on defining the landscape of epigenetic and genetic lesions that underlie pediatric MLL-R leukemia at diagnosis and at relapse. We use high-resolution genomic methods to identify aberrant genes and signaling pathways, in combination with murine models, to unravel their impact on tumor behavior. These studies will enhance our understanding of the differences between infant and non-infant MLL-R leukemia, and the nature of alterations that drive its development, and will increase our understanding about the genetic basis of relapse. In addition, we are interested in defining how distinct tumor clones cooperate to drive the growth of MLL-R leukemia, and the mechanisms behind clonal cooperation using murine models and in vitro assays to determine its biological significance. Our studies will advance our understanding of leukemogenesis, and may influence how leukemia is diagnosed, classified and treated in the future, and will help identify targets for novel treatment modalities.

Highlighted research outputs

Axel Hyrenius-Wittsten, Mattias Pilheden, Helena Sturesson, Jenny Hansson, Michael P. Walsh, Guangchun Song, Julhash U. Kazi, Jian Liu, Ramprasad Ramakrishan, Cristian Garcia-Ruiz, Stephanie Nance, Pankaj Gupta, Jinghui Zhang, Lars Rönnstrand, Anne Hultquist, James R. Downing, Karin Lindkvist-Petersson, Kajsa Paulsson, Marcus Järås, Tanja A. Gruber & 2 others, Jing Ma & Anna K. Hagström-Andersson, 2018 Dec 1, In: Nature Communications. 9, 1, 1770.

Research output: Contribution to journalArticle

Zachary J Faber, Xiang Chen, Amanda Larson Gedman, Kristy Boggs, Jinjun Cheng, Jing Ma, Ina Radtke, Jyh-Rong Chao, Michael P Walsh, Guangchun Song, Anna K Andersson, Jinjun Dang, Li Dong, Yu Liu, Robert Huether, Zhongling Cai, Heather Mulder, Gang Wu, Michael Edmonson, Michael Rusch & 29 others, Chunxu Qu, Yongjin Li, Bhavin Vadodaria, Jianmin Wang, Erin Hedlund, Xueyuan Cao, Donald Yergeau, Joy Nakitandwe, Stanley B Pounds, Sheila Shurtleff, Robert S Fulton, Lucinda L Fulton, John Easton, Evan Parganas, Ching-Hon Pui, Jeffrey E Rubnitz, Li Ding, Elaine R Mardis, Richard K Wilson, Tanja A Gruber, Charles G Mullighan, Richard F Schlenk, Peter Paschka, Konstanze Döhner, Hartmut Döhner, Lars Bullinger, Jinghui Zhang, Jeffery M Klco & James R Downing, 2016 Oct 31, In: Nature Genetics. 48, p. 1551–1556 6 p.

Research output: Contribution to journalLetter

Anna Andersson, Jing Ma, Jianmin Wang, Xiang Chen, Amanda Larson Gedman, Jinjun Dang, Joy Nakitandwe, Linda Holmfeldt, Matthew Parker, John Easton, Robert Huether, Richard Kriwacki, Michael Rusch, Gang Wu, Yongjin Li, Heather Mulder, Susana Raimondi, Stanley Pounds, Guolian Kang, Lei Shi & 30 others, Jared Becksfort, Pankaj Gupta, Debbie Payne-Turner, Bhavin Vadodaria, Kristy Boggs, Donald Yergeau, Jayanthi Manne, Guangchun Song, Michael Edmonson, Panduka Nagahawatte, Lei Wei, Cheng Cheng, Deqing Pei, Rosemary Sutton, Nicola C Venn, Albert Chetcuti, Amanda Rush, Daniel Catchpoole, Jesper Heldrup, Thoas Fioretos, Charles Lu, Li Ding, Ching-Hon Pui, Sheila Shurtleff, Charles G Mullighan, Elaine R Mardis, Richard K Wilson, Tanja A Gruber, Jinghui Zhang & James R Downing, 2015, In: Nature Genetics. 47, 4, p. 330-U192

Research output: Contribution to journalArticle

Maria E Figueroa, Shann-Ching Chen, Anna K Andersson, Letha A Phillips, Yushan Li, Jason Sotzen, Mondira Kundu, James R Downing, Ari Melnick & Charles G Mullighan, 2013 Jul, In: Journal of Clinical Investigation. 123, 7, p. 3099-111 13 p.

Research output: Contribution to journalArticle

Linda Holmfeldt, Lei Wei, Ernesto Diaz-Flores, Michael Walsh, Jinghui Zhang, Li Ding, Debbie Payne-Turner, Michelle Churchman, Anna Andersson, Shann-Ching Chen, Kelly McCastlain, Jared Becksfort, Jing Ma, Gang Wu, Samir N. Patel, Susan L. Heatley, Letha A. Phillips, Guangchun Song, John Easton, Matthew Parker & 43 others, Xiang Chen, Michael Rusch, Kristy Boggs, Bhavin Vadodaria, Erin Hedlund, Christina Drenberg, Sharyn Baker, Deqing Pei, Cheng Cheng, Robert Huether, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Yashodhan Tabib, David J. Dooling, Kerri Ochoa, Mark Minden, Ian D. Lewis, L. Bik To, Paula Marlton, Andrew W. Roberts, Gordana Raca, Wendy Stock, Geoffrey Neale, Hans G. Drexler, Ross A. Dickins, David W. Ellison, Sheila A. Shurtleff, Ching-Hon Pui, Raul C. Ribeiro, Meenakshi Devidas, Andrew J. Carroll, Nyla A. Heerema, Brent Wood, Michael J. Borowitz, Julie M. Gastier-Foster, Susana C. Raimondi, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Stephen P. Hunger, Mignon L. Loh & Charles G. Mullighan, 2013, In: Nature Genetics. 45, 3, p. 242-252

Research output: Contribution to journalArticle

Anna Andersson, Tor Olofsson, David Lindgren, Björn Nilsson, Cecilia Ritz, Patrik Edén, Carin Lassen, Johan Råde, Magnus Fontes, Helena Mörse, Jesper Heldrup, Mikael Behrendtz, Felix Mitelman, Mattias Höglund, Bertil Johansson & Thoas Fioretos, 2005, In: Proceedings of the National Academy of Sciences. 102, 52, p. 19069-19074

Research output: Contribution to journalArticle

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