Annika JögiLäkare, Laboratory Researcher, Associate professor, M. Sci., M. Med., MD, PhD, M. Sci
Research areas and keywords
UKÄ subject classification
- Medical and Health Sciences
- Cell Biology
- Basic Medicine
- Cell and Molecular Biology
- Cancer and Oncology
- Cancer and Oncology, Tumor microenvironment , Breast cancer, Therapy resistance, Tumor models, Tumor hypoxia
Impact of the tumor microenvironment and hypoxia on breast cancer and therapy resistance
Breast cancer is the most common cancer in women with ~9000 cases yearly in Sweden. Treatment with surgery, often combined with additional therapy such as radiation and anti-estrogens, relieves tumor burden. In some cases re-growth or metastasis occur, which is linked to poor patient outcome.
The microenvironment within tumors differs from that of healthy tissues, especially oxygen delivery is poor leading to hypoxia. Intra tumor hypoxia leads to poor response to several cancer therapies including anti-estrogens, chemo and radiation.
We want to explore why some patients experience cancer recurrence, metastasis and therapy resistance with the aim to improve and specialize treatment. Therefore we molecularly map how hypoxia and factors induced by hypoxia contribute to anti-estrogen resistance. In parallel we investigate how the presence of intra-tumor hypoxia correlates to patient outcome.
Recent research outputs
Research output: Contribution to journal › Article