Atena Malakpour Permlid

Doctoral Student

Research

I am from the northern part of Iran, near the coast of the Caspian Sea. I have always been fascinated by the field of Biology.  I studied Microbiology for my undergraduate degree and continued to get a master degree in molecular biology at Lund University in 2013. My motivation for being a part of molecular biology field lies in the fact that it is a foundation of our capability to treat almost all human diseases. I got the opportunity to work with some new anti-cancer compounds and their inhibitory effect on NF-κB signaling pathway in breast cancer cells during my master studies. Right after graduation, I was accepted as a PhD candidate under the supervision of professor Stina Oredsson and Per Fredrik Johansson in Biology department, Lund University in 2016.

Recent findings have shown that cells often exhibit different behaviour when they are separated from their native three dimensional (3D) tissues and confined to a monolayer cell cultures (2D). The development of complex synthetic 3D cell culture models, which can mimic the native extracellular matrix, represent an important step towards a more in vivo-like cell culture system.

In my project, we are working on the development of a novel 3D cell culture model using different types of polymers such as polycaprolactone (PCL) and polylactide (PLA). A modified electrospinning method is utilized to fabricate highly porous 3D nanofiber scaffolds, mimicking the collagen fibres of the extracellular matrix. We also investigate the proliferation and migration of primarily various breast cancer cell lines and other cells such as fibroblasts, immune cells and co-culture of such cells in randomly-oriented and aligned fibre scaffolds. The effect of different new anti-cancer compounds on the cancer cells and cancer stem cells proliferation and migration will be investigated as well.

Beside using 3D systems as excellent alternative in vivo models, we are replacing medium supplemented with donor horse serum instead of the commonly used but animal ethically questionable fetal calf serum in this project. Our goal is to contribute in replacing, refining and reducing the use of animal models in cancer research in future.

Recent research outputs

Atena Malakpour Permlid, Rocci, P., Fredlund, E., Fält, F., Önell, E., Per Fredrik Johansson & Stina Oredsson, 2019 May 10, In : Toxicology in Vitro. 60, p. 51-60

Research output: Contribution to journalArticle

Wendy Soria Sotillo, Villagomez, R., Smiljanic, S., Huang, X., Atena Malakpour, Kempengren, S., Rodrigo, G., Almanza, G., Olov Sterner & Stina Oredsson, 2017, In : PLoS ONE. 12, 9, p. e0184304

Research output: Contribution to journalArticle

Shinde, S., El-Schich, Z., Atena Malakpour, Wan, W., Dizeyi, N., Mohammadi, R., Rurack, K., Gjörloff Wingren, A. & Sellergren, B., 2015 Sep 28, In : Journal of the American Chemical Society. 137, 43, p. 13908-13912

Research output: Contribution to journalArticle

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