Bo Baldetorp

Senior Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology


  • Melanoma, Endometrial Cancer, Proteomics


Project: Studies at protein level, on human cancer cell lines and malignant melanomas for the identification of biomarkers for metastasizing and targeted therapy.
The aim of the project is to find biomarkers for malignant melonoma which will develop metastasis, and markers for sensitivity and resistance to treatment in malignant melanoma. We will investigate chemotherapeutic drugs and immunologically based agents. We are focusing on biomarkers involved in various aspects of the regulation of cell cycle progression and apoptosis from the gene level to the functional protein level. We aim at finding combinations of predictive biomarkers at the gene, mRNA, and protein levels for targeted treatment.

Project: Studies on prognostic cellbiologic indicators in endometrioid endometrial carcinoma.
Cancer treatment is often dependent on the knowledge of reliable prognostic factors; it is important to create adequate high- and low risk groups in order to identify patients that need a more advanced therapy and to spare those who do not. Flowcytometric (FCM) DNA ploidy, diploid versus non-diploid, is used according to the national Swedish health care protocol for FIGO stage I endometrial carcinoma. DNA FCM has been improved leading to reproducible estimation of S-phase fraction, proliferation, (SPF). In this project we study the prognostic importance of data from flow cytometric DNA ploidy status and SPF analyses, performed on formalin fixed and paraffin embedded curettage samples, with classic histopathologic factors in relation to overall, progression-free, disease specific and relative survival and to location of recurrence on patients with endometrial carcinoma.

Highlighted research outputs

H Sigurdsson, Bo Baldetorp, Åke Borg, M Dalberg, Mårten Fernö, Dick Killander & Håkan Olsson, 1990, In: New England Journal of Medicine. 322, 15, p. 1045-1053

Research output: Contribution to journalArticle

Bo Baldetorp, Pär-Ola Bendahl, Mårten Fernö, Kalle Alanen, Ulla Delle, Ursula Falkmer, Britt Hansson-Aggesjö, Thomas Hockenström, Anders Lindgren, Lotta Mossberg, Stig Nordling, Helgi Sigurdsson, Olle Stål & Tapio Visakorpi, 1995, In: Cytometry. 22, 2, p. 115-127

Research output: Contribution to journalArticle

C B Bagwell, G M Clark, F Spyratos, A Chassevent, Pär-Ola Bendahl, O Stal, D Killander, M L Jourdan, S Romain, B Hunsberger & Bo Baldetorp, 2001, In: Cytometry. 46, 3, p. 121-135

Research output: Contribution to journalArticle

Charlotte Welinder, Krzysztof Pawlowski, Yutaka Sugihara, Maria Yakovleva, Göran B Jönsson, Christian Ingvar, Lotta Lundgren, Bo Baldetorp, Håkan Olsson, Melinda Rezeli, Bo Jansson, Thomas Laurell, Thomas Fehniger, Balazs Döme, Johan Malm, Elisabet Wieslander, Toshihide Nishimura & György Marko-Varga, 2015, In: PLoS ONE. 10, 4, e0123661.

Research output: Contribution to journalArticle

Rasmus W Green, Sanna Engblom, Bo Baldetorp, Linda Werner Hartman, Anna Måsbäck & Maria Bjurberg, 2015, In: Acta Obstetricia et Gynecologica Scandinavica. 94, 10, p. 1064-1073

Research output: Contribution to journalArticle

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