Catharina Svanborg

Senior Professor
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  1. 2019
  2. Beta-sheet-specific interactions with heat shock proteins define a mechanism of delayed tumor cell death in response to HAMLET

    Nadeem, A., Ho, J. C. S., Tran, T. H., Paul, S., Victoria Granqvist, Despretz, N. & Catharina Svanborg, 2019 May 11, In : Journal of Molecular Biology.

    Research output: Contribution to journalArticle

  3. 2018
  4. Neuroepithelial control of mucosal inflammation in acute cystitis

    Daniel S.C. Butler, Ines Ambite, Nagy, K., Caterina Cafaro, Ahmed, A., Nadeem, A., Filenko, N., Thi Hien Tran, Karl Erik Andersson, Wullt, B., Manoj Puthia & Catharina Svanborg, 2018 Jul 20, In : Scientific Reports. 8, 1, 11015.

    Research output: Contribution to journalArticle

  5. 2017
  6. HAMLET – A protein-lipid complex with broad tumoricidal activity

    Ho, J. C. S., Nadeem, A. & Catharina Svanborg, 2017 Jan 15, In : Biochemical and Biophysical Research Communications. 482, 3, p. 454-458 5 p.

    Research output: Contribution to journalReview article

  7. 2016
  8. Protein-dependent membrane interaction of a partially disordered protein complex with oleic acid: Implications for cancer lipidomics

    Chaudhuri, A., Prasanna, X., Agiru, P., Chakraborty, H., Anna Rydström, Ho, J. C. S., Catharina Svanborg, Sengupta, D. & Chattopadhyay, A., 2016 Oct 12, In : Scientific Reports. 6, 35015.

    Research output: Contribution to journalArticle

  9. Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets

    Ines Ambite, Manoj Puthia, Nagy, K., Caterina Cafaro, Nadeem, A., Daniel S C Butler, Rydström, G., Filenko, N. A., Wullt, B., Miethke, T. & Catharina Svanborg, 2016 Oct 1, In : PLoS Pathogens. 12, 10, e1005848.

    Research output: Contribution to journalArticle

  10. Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation

    Waldhuber, A., Manoj Puthia, Wieser, A., Cirl, C., Dürr, S., Neumann-Pfeifer, S., Albrecht, S., Römmler, F., Müller, T., Zheng, Y., Schubert, S., Groß, O., Catharina Svanborg & Miethke, T., 2016 Jul 1, In : Journal of Clinical Investigation. 126, 7, p. 2425-36 12 p.

    Research output: Contribution to journalArticle

  11. A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

    Waldhuber, A., Snyder, G. A., Römmler, F., Cirl, C., Müller, T., Xiao, T. S., Catharina Svanborg & Miethke, T., 2016, In : Pathogens (Basel, Switzerland). 5, 25, p. 1-8

    Research output: Contribution to journalArticle

  12. Asymtomatic Bacteriuria as a Model to Study the Coevolution of Hosts and Bacteria.

    Dobrindt, U., Wullt, B. & Catharina Svanborg, 2016, In : Pathogens (Basel, Switzerland). 5, 1, p. 1-8

    Research output: Contribution to journalReview article

  13. Bacterial suppression of RNA polymerase II-dependent host gene expression

    Ines Ambite, Lutay, N., Stork, C., Dobrindt, U., Wullt, B. & Catharina Svanborg, 2016, In : Pathogens (Basel, Switzerland). 5, 3, 49.

    Research output: Contribution to journalReview article

  14. Susceptibility to urinary tract infection: Benefits and hazards of the antibacterial host response

    Ines Ambite, Nagy, K., Gabriela Godaly, Manoj Puthia, Wullt, B. & Catharina Svanborg, 2016, In : Microbiology spectrum. 4, 3, UTI-0019-2014.

    Research output: Contribution to journalReview article

  15. Urinary Tract Infection Molecular Mechanisms and Clinical Translation.

    Gabriela Godaly, Ines Ambite, Manoj Puthia, Nadeem, A., Ho, J., Nagy, K., Huang, Y., Rydström, G. & Catharina Svanborg, 2016, In : Pathogens (Basel, Switzerland). 5, 1

    Research output: Contribution to journalReview article

  16. 2015
  17. Protein receptor-independent plasma membrane remodeling by HAMLET: a tumoricidal protein-lipid complex.

    Nadeem, A., Sanborn, J., Gettel, D. L., James, H. C. S., Anna Rydström, Ngassam, V. N., Klausen, T. K., Pedersen, S. F., Lam, M., Parikh, A. N. & Catharina Svanborg, 2015, In : Scientific Reports. 5, 16432.

    Research output: Contribution to journalArticle

  18. The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET.

    Ho, J., Sielaff, H., Nadeem, A., Catharina Svanborg & Grüber, G., 2015, In : Journal of Molecular Biology. 427, 10, p. 1866-1874

    Research output: Contribution to journalArticle

  19. 2014
  20. Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens.

    Sheppard, N. C., Brinckmann, S. A., Gartlan, K. H., Manoj Puthia, Catharina Svanborg, Krashias, G., Eisenbarth, S. C., Flavell, R. A., Sattentau, Q. J. & Wegmann, F., 2014, In : International Immunology. 26, 10, p. 531-538

    Research output: Contribution to journalArticle

  21. Rare emergence of symptoms during long-term asymptomatic E. coli 83972 carriage, without altered virulence factor repertoire.

    Köves, B., Salvador, E., Grönberg Hernandez, J., Zdziarski, J., Wullt, B., Catharina Svanborg & Dobrindt, U., 2014, In : Journal of Urology. 191, 2, p. 519-528

    Research output: Contribution to journalArticle

  22. The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection.

    Jaillon, S., Moalli, F., Ragnarsdottir, B., Bonavita, E., Manoj Puthia, Riva, F., Barbati, E., Nebuloni, M., Cvetko Krajinovic, L., Markotic, A., Valentino, S., Doni, A., Tartari, S., Graziani, G., Montanelli, A., Delneste, Y., Catharina Svanborg, Garlanda, C. & Mantovani, A., 2014, In : Immunity. 40, 4, p. 621-632

    Research output: Contribution to journalArticle

  23. 2013
  24. A Unifying Mechanism for Cancer Cell Death through Ion Channel Activation by HAMLET.

    Storm, P., Kjaer Klausen, T., Trulsson, M., Ho Cs, J., Dosnon, M., Westergren, T., Chao, Y., Anna Rydström, Yang, H., Pedersen, S. F. & Catharina Svanborg, 2013, In : PLoS ONE. 8, 3, e58578.

    Research output: Contribution to journalArticle

  25. Bacterial control of host gene expression through RNA polymerase II

    Lutay, N., Ines Ambite, Grönberg Hernandez, J., Rydstrom, G., Ragnarsdottir, B., Manoj Puthia, Nadeem, A., Zhang, J., Storm, P., Dobrindt, U., Wullt, B. & Catharina Svanborg, 2013, In : Journal of Clinical Investigation. 123, 6, p. 2366-2379

    Research output: Contribution to journalArticle

  26. Electrostatic interactions play an essential role in the binding of oleic acid with a-lactalbumin in the HAMLET-like complex: A study using charge-specific chemical modifications

    Xie, Y., Min, S., Harte, N. P., Kirk, H., O'Brien, J. E., Voorheis, H. P., Catharina Svanborg & Mok, K., 2013, In : Proteins. 81, 1, p. 1-17

    Research output: Contribution to journalArticle

  27. Lipids as Tumoricidal Components of Human Alpha-lactalbumin Made Lethal to Tumor Cells (HAMLET); Unique and Shared Effects on Signaling and Death.

    Ho Cs, J., Storm, P., Anna Rydström, Bowen, B., Alsin, F., Sullivan, L., Ines Ambite, Mok, K. H., Northen, T. & Catharina Svanborg, 2013, In : Journal of Biological Chemistry. 288, 24, p. 17460-17471

    Research output: Contribution to journalArticle

  28. 2012
  29. Alternatively folded proteins with unexpected beneficial functions

    Min, S., Meehan, J., Sullivan, L. M., Harte, N. P., Xie, Y., Davey, G. P., Catharina Svanborg, Brodkorb, A. & Mok, K., 2012, In : Biochemical Society Transactions. 40, p. 746-751

    Research output: Contribution to journalArticle

  30. Comparison of Asymptomatic Bacteriuria Escherichia coli Isolates from Healthy Individuals versus Those from Hospital Patients Shows that Long-Term Bladder Colonization Selects for Attenuated Virulence Phenotypes

    Salvador, E., Wagenlehner, F., Koehler, C-D., Mellmann, A., Hacker, J., Catharina Svanborg & Dobrindt, U., 2012, In : Infection and Immunity. 80, 2, p. 668-678

    Research output: Contribution to journalArticle

  31. Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?

    Norinder, B. S., Köves, B., Yadav, M., Brauner, A. & Catharina Svanborg, 2012, In : Microbial Pathogenesis. 52, 1, p. 10-16

    Research output: Contribution to journalArticle

  32. HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers

    Baumann, A., Gjerde, A. U., Ying, M., Catharina Svanborg, Holmsen, H., Glomm, W. R., Martinez, A. & Halskau, O., 2012, In : Journal of Molecular Biology. 418, 1-2, p. 90-102

    Research output: Contribution to journalArticle

  33. HAMLET: functional properties and therapeutic potential.

    Ho Cs, J., Anna Rydström, Trulsson, M., Bålfors, J., Storm, P., Manoj Puthia, Nadeem, A. & Catharina Svanborg, 2012, In : Future Oncology. 8, 10, p. 1301-1313

    Research output: Contribution to journalArticle

  34. Low Resolution Solution Structure of HAMLET and the Importance of Its Alpha-Domains in Tumoricidal Activity.

    Ho Cs, J., Anna Rydström, Manimekalai, M. S. S., Catharina Svanborg & Grüber, G., 2012, In : PLoS ONE. 7, 12, e53051.

    Research output: Contribution to journalArticle

  35. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

    Wegmann, F., Gartlan, K. H., Harandi, A. M., Brinckmann, S. A., Coccia, M., Hillson, W. R., Kok, W. L., Cole, S., Ho, L-P., Lambe, T., Puthia, M., Svanborg, C., Scherer, E. M., Krashias, G., Williams, A., Blattman, J. N., Greenberg, P. D., Flavell, R. A., Moghaddam, A. E., Sheppard, N. C. & 1 othersSattentau, Q. J., 2012, In : Nature Biotechnology. 30, 9, p. 883-888

    Research output: Contribution to journalArticle

  36. 2011
  37. Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.

    Svensson, M., Yadav, M., Holmqvist, B., Lutay, N., Catharina Svanborg & Gabriela Godaly, 2011, In : Kidney International. 80, 10, p. 1064-1072

    Research output: Contribution to journalArticle

  38. Apoptosis-Like Death in Bacteria Induced by HAMLET, a Human Milk Lipid-Protein Complex

    Anders P Håkansson, Roche-Hakansson, H., Mossberg, A. & Catharina Svanborg, 2011, In : PLoS ONE. 6, 3, e17717.

    Research output: Contribution to journalArticle

  39. Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.

    Storm, P., Sonja Aits, Puthia, M. K., Urbano, A., Northen, T., Powers, S., Bowen, B., Chao, Y., Reindl, W., Lee, D. Y., Sullivan, N. L., Zhang, J., Trulsson, M., Yang, H., Watson, J. D. & Catharina Svanborg, 2011, In : Oncogene. 30, p. 4765-4779

    Research output: Contribution to journalArticle

  40. Genetic control of the variable innate immune response to asymptomatic bacteriuria.

    Grönberg Hernandez, J., Sundén, F., Connolly, J., Catharina Svanborg & Wullt, B., 2011, In : PLoS ONE. 6, 11, e28289.

    Research output: Contribution to journalArticle

  41. Genetics of innate immunity and UTI susceptibility.

    Ragnarsdottir, B., Lutay, N., Grönberg Hernandez, J., Köves, B. & Catharina Svanborg, 2011, In : Nature Reviews Urology. 8, p. 449-468

    Research output: Contribution to journalArticle

  42. HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment.

    Trulsson, M., Yu, H., Gisselsson, L., Chao, Y., Urbano, A., Sonja Aits, Mossberg, A. & Catharina Svanborg, 2011, In : PLoS ONE. 6, 3, e17179.

    Research output: Contribution to journalArticle

  43. MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells

    Brest, P., Lassalle, S., Hofman, V., Bordone, O., Tanga, V. G., Bonnetaud, C., Moreilhon, C., Rios, G., Santini, J., Barbry, P., Catharina Svanborg, Mograbi, B., Mari, B. & Hofman, P., 2011, In : Endocrine-Related Cancer. 18, 6, p. 711-719

    Research output: Contribution to journalArticle

  44. 2010
  45. HAMLET interacts with lipid membranes and perturbs their structure and integrity.

    Mossberg, A., Puchades, M., Halskau, Ø., Baumann, A., Lanekoff, I., Chao, Y., Martinez, A., Catharina Svanborg & Karlsson, R., 2010, In : PLoS ONE. 5, 2, e9384.

    Research output: Contribution to journalArticle

  46. HAMLET Treatment Delays Bladder Cancer Development.

    Mossberg, A., Hou, Y., Svensson, M., Holmqvist, B. & Catharina Svanborg, 2010, In : The Journal of urology. 183, p. 1590-1597

    Research output: Contribution to journalArticle

  47. Host Imprints on Bacterial Genomes-Rapid, Divergent Evolution in Individual Patients

    Zdziarski, J., Brzuszkiewicz, E., Wullt, B., Liesegang, H., Biran, D., Voigt, B., Grönberg Hernandez, J., Ragnarsdottir, B., Hecker, M., Ron, E. Z., Daniel, R., Gottschalk, G., Hacker, J., Catharina Svanborg & Dobrindt, U., 2010, In : PLoS Pathogens. 6, 8

    Research output: Contribution to journalArticle

  48. Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.

    Yadav, M., Zhang, J., Fischer, H., Huang, W., Lutay, N., Cirl, C., Lum, J., Miethke, T. & Catharina Svanborg, 2010, In : PLoS Pathogens. 6, 9

    Research output: Contribution to journalArticle

  49. Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection.

    Fischer, H., Lutay, N., Ragnarsdottir, B., Yadav, M., Jönsson, K., Urbano, A., Al Hadad, A., Rämisch, S., Storm, P., Dobrindt, U., Salvador, E., Diana Karpman, Jodal, U. & Catharina Svanborg, 2010, In : PLoS Pathogens. 6, 9, p. 1-17 e1001109.

    Research output: Contribution to journalArticle

  50. Structure and function of human α-lactalbumin made lethal to tumor cells (HAMLET)-type complexes.

    Mossberg, A., Hun Mok, K., Morozova-Roche, L. A. & Catharina Svanborg, 2010, In : The FEBS Journal. 277, 22, p. 4614-4625

    Research output: Contribution to journalReview article

  51. Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection.

    Ragnarsdottir, B., Jönsson, K., Urbano, A., Grönberg Hernandez, J., Lutay, N., Tammi, M., Gustafsson, M., Lundstedt, A-C., Leijonhufvud, I., Diana Karpman, Wullt, B., Lennart Truedsson, Jodal, U., Andersson, B. & Catharina Svanborg, 2010, In : PLoS ONE. 5, 5, e10734.

    Research output: Contribution to journalArticle

  52. 2009
  53. HAMLET, a tumoricidal molecular complex from human milk

    C Svanborg, S Aits, Brest, P., Gustafsson, L., Mok, K., Moreillhon, C., Mossberg, A., Pettersson, J., Storm, P. & Trulsson, M., 2009 Jul 24, In : BMC Proceedings. 3, Suppl 5, p. S11

    Research output: Contribution to journalPublished meeting abstract

  54. alpha-Lactalbumin, Engineered to be Non-native and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A new biological function resulting from partial unfolding.

    Pettersson, J., Mossberg, A., Trulsson, M., Yong, Y. J., Min, S., Lim, Y., O'Brien, J. E., Catharina Svanborg & Mok, K., 2009, In : Journal of Molecular Biology. 394, 5, p. 994-1010

    Research output: Contribution to journalArticle

  55. Can misfolded proteins be beneficial? The HAMLET case.

    Pettersson, J., Sonja Aits, Gustafsson, L., Mossberg, A., Storm, P., Trulsson, M., Persson, F., Hun Mok, K. & Catharina Svanborg, 2009, In : Annals of Medicine. 41, p. 162-176

    Research output: Contribution to journalArticle

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