Cecilia Hegardt
Researcher- 2020
The mutational landscape of the SCAN‐B real‐world primary breast cancer transcriptome
Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon-Christersson, Cecilia Hegardt, Jari Häkkinen, Anthony George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Ryden, Åke Borg & Lao Saal, 2020 Sep 14, In : EMBO Molecular Medicine. 12, 10, e12118.Research output: Contribution to journal › Article
Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer
Christer Larsson, Anna Ehinger, Sofia Winslow, Karin Leandersson, Marie Klintman, Ludvig Dahl, Johan Vallon-christersson, Jari Häkkinen, Cecilia Hegardt, Jonas Manjer, Lao Saal, Lisa Rydén, Martin Malmberg, Åke Borg & Niklas Loman, 2020 Jul 6, In : npj Breast Cancer. 6, 1, 28.Research output: Contribution to journal › Article
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Defining the mutational landscape of 3,217 primary breast cancer transcriptomes through large-scale RNA-seq within the Sweden Cancerome Analysis Network: Breast Project (SCAN-B; NCT03430492).
Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon-christersson, Cecilia Hegardt, Jari Häkkinen, Anthony M George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Åke Borg & Lao H. Saal, 2020 May 20, In : Journal of Clinical Oncology. 38, 15_suppl, p. 518-518Research output: Contribution to journal › Published meeting abstract
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Whole-genome sequencing of triple negative breast cancers in a standard population-based clinical setting
Johan Staaf, Dominik Glodzik, Ana Bosch Campos, Johan Vallon-Christersson, Christel Reuterswärd, Jari Häkkinen, Andrea Degasperi, Tauanne Dias Amarante, Lao Saal, Cecilia Hegardt, Hilary Stobart, Anna Ehinger, Christer Larsson, Lisa Ryden, Niklas Loman, Martin Malmberg, Anders Kvist, Hans Ehrencrona, Helen R. Davies, Åke Borg & 1 others, , 2020 Feb 6, In : Breast Cancer Research and Treatment. 180, p. 531-532Research output: Contribution to journal › Published meeting abstract
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Abstract P1-18-10: Preoperative treatment of HER2-positive breast cancer in South Sweden. A retrospective, comprehensive survey of neo-adjuvant treated HER2-positve breast cancer in the SCAN-B project 2010-2017
Martin Malmberg, Christer Larsson, Johan Vallon-Christersson, Anna Ehinger, Cecilia Hegardt, Fredrika Killander, Lisa Ryden, Lao Saal, Niklas Loman & Åke Borg, 2020 Feb, In : Cancer research. Supplement. 80, Issue 4 Supplement, p. P1-18-10Research output: Contribution to journal › Published meeting abstract
The Mutational Landscape of the SCAN-B Real-World Primary Breast Cancer Transcriptome
Christian Brueffer, Sergii Gladchuk, Christof Winter, Johan Vallon-Christersson, Cecilia Hegardt, Jari Häkkinen, Anthony George, Yilun Chen, Anna Ehinger, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Ryden, Åke Borg & Lao Saal, 2020 Jan 31, bioRxiv.Research output: Other contribution › Miscellaneous
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
Dominik Glodzik, Ana Bosch, Johan Hartman, Mattias Aine, Johan Vallon-Christersson, Christel Reuterswärd, Anna Karlsson, Shamik Mitra, Emma Niméus, Karolina Holm, Jari Häkkinen, Cecilia Hegardt, Lao H. Saal, Christer Larsson, Martin Malmberg, Lisa Rydén, Anna Ehinger, Niklas Loman, Anders Kvist, Hans Ehrencrona & 3 others, , 2020, In : Nature Communications. 11, 1, 3747.Research output: Contribution to journal › Article
Psychological resilience and health-related quality of life in Swedish women with newly diagnosed breast cancer
Åsa Mohlin, Ulrika Axelsson, Pär Ola Bendahl, Carl Borrebaeck, Cecilia Hegardt, Per Johnsson, Ingalill Rahm Hallberg & Lisa Rydén, 2020, In : Cancer Management and Research. 12, p. 12041-12051 11 p.Research output: Contribution to journal › Article
- 2019
Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series
Johan Vallon-Christersson, Jari Häkkinen, Cecilia Hegardt, Lao Saal, Christer Larsson, Anna Ehinger, H Lindman, Helena Olofsson, Tobias Sjoblom, Fredrik Wärnberg, Lisa Rydén, Niklas Loman, Martin Malmberg, Åke Borg & Johan Staaf, 2019 Aug 21, In : Scientific Reports. 9, 12184.Research output: Contribution to journal › Article
Agreement between molecular subtyping and surrogate subtype classification: a contemporary population-based study of ER-positive/HER2-negative primary breast cancer
Christine Lundgren, Pär-Ola Bendahl, Anna Ehinger, Cecilia Hegardt, Christer Larsson, Niklas Loman, Martin Malmberg, Helena Olofsson, Lao Saal, Tobias Sjoblom, H Lindman, Marie Klintman, Jari Häkkinen, Johan Vallon-Christersson, Mårten Fernö, Lisa Rydén & Maria Ekholm, 2019 Aug 20, In : Breast Cancer Research and Treatment. p. 1-9 9 p.Research output: Contribution to journal › Article
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Prediction of lymph node metastasis in breast cancer by gene expression and clinicopathological models: Development and validation within a population based cohort.
Looket Dihge, Johan Vallon-Christersson, Cecilia Hegardt, Lao Saal, Jari Häkkinen, Christer Larsson, Anna Ehinger, Niklas Loman, Martin Malmberg, Pär-Ola Bendahl, Åke Borg, Johan Staaf & Lisa Rydén, 2019 Jul 24, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 25, 21, p. 6368-6381Research output: Contribution to journal › Article
Refinement of breast cancer molecular classification by miRNA expression profiles
Rolf Søkilde, Helena Persson, Anna Ehinger, Anna Chiara Pirona, Mårten Fernö, Cecilia Hegardt, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Lao Saal, Åke Borg, Johan Vallon-Christerson & Carlos Rovira, 2019 Jun 17, In : BMC Genomics. 20, 1, 12 p., 503.Research output: Contribution to journal › Article
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Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study
Johan Staaf, Dominik Glodzik, Ana Bosch, Johan Vallon-Christersson, Christel Reuterswärd, Jari Häkkinen, Andrea Degasperi, Tauanne Dias Amarante, Lao H Saal, Cecilia Hegardt, Hilary Stobart, Anna Ehinger, Christer Larsson, Lisa Rydén, Niklas Loman, Martin Malmberg, Anders Kvist, Hans Ehrencrona, Helen R Davies, Åke Borg & 1 others, , 2019, In : Nature Medicine. 25, p. 1526–1533Research output: Contribution to journal › Article
- 2018
The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
Xiaoli Huang, Björn Borgström, John Stegmayr, Yasmin Abassi, Monika Kruszyk, Hakon Leffler, Lo Persson, Sebastian Albinsson, Ramin Massoumi, Ivan G. Scheblykin, Cecilia Hegardt, Stina Oredsson & Daniel Strand, 2018 Jun 27, In : ACS Central Science. 4, 6, p. 760-767 8 p.Research output: Contribution to journal › Article
Clinical Value of RNA Sequencing–Based Classifiers for Prediction of the Five Conventional Breast Cancer Biomarkers: A Report From the Population-Based Multicenter Sweden Cancerome Analysis Network—Breast Initiative
Christian Brueffer, Johan Vallon-Christersson, Dorthe Grabau, Anna Ehinger, Jari Häkkinen, Cecilia Hegardt, Janne Malina, Yilun Chen, Pär-Ola Bendahl, Jonas Manjer, Martin Malmberg, Christer Larsson, Niklas Loman, Lisa Rydén, Åke Borg & Lao H. Saal, 2018 Mar 9, In : JCO Precision Oncology. 2, p. 1-18Research output: Contribution to journal › Article
Abstract P1-06-01: Putting multigene signatures to the test: Prognostic assessment in population-based contemporary clinical breast cancer
Johan Staaf, Johan Vallon-Christersson, Jari Häkkinen, Lao Saal, Cecilia Hegardt, Christer Larsson, Anna Ehinger, Lisa Rydén, Niklas Loman, Martin Malmberg & Åke Borg, 2018 Feb, In : Cancer research. Supplement. 78, 4Research output: Contribution to journal › Published meeting abstract
Abstract P2-02-09: Breast cancer subtype distribution and circulating tumor DNA in response to neoadjuvant chemotherapy: Experiences from a preoperative cohort within SCAN-B
Niklas Loman, Yilun Chen, Kristina Aaltonen, Christian Brueffer, Anthony George, Lina Zander, Johan Vallon-Christersson, Jari Häkkinen, Daniel Förnvik, Robert Rigo, Anna Ehinger, Martin Malmberg, Christer Larsson, Cecilia Hegardt, Åke Borg, Lisa Rydén & Lao Saal, 2018 Feb, In : Cancer research. Supplement. 78, 4Research output: Contribution to journal › Published meeting abstract
Abstract P3-02-02: Concordance between immunohistochemical and gene-expression based subtyping of early breast cancer using core needle biopsies and surgical specimens - experices from SCAN-B
G Morgan, Christer Larsson, Balázs Tahin, Johan Vallon-Christersson, Jari Häkkinen, Anna Ehinger, Martin Malmberg, Cecilia Hegardt, Åke Borg, Lisa Rydén, Lao Saal, Ingrid Hedenfalk & Niklas Loman, 2018 Feb, In : Cancer research. Supplement. 78, 4Research output: Contribution to journal › Published meeting abstract
Abstract P4-09-03: On the development and clinical value of RNA-sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter SCAN-B study
Christian Brueffer, Johan Vallon-Christersson, Dorthe Grabau, Anna Ehinger, Jari Häkkinen, Cecilia Hegardt, Janne Malina, Yilun Chen, Pär-Ola Bendahl, Jonas Manjer, Martin Malmberg, Christer Larsson, Niklas Loman, Lisa Rydén, Åke Borg & Lao Saal, 2018 Feb, In : Cancer research. Supplement. 78, 4Research output: Contribution to journal › Published meeting abstract
Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative
Lisa Rydén, Niklas Loman, Christer Larsson, Cecilia Hegardt, Johan Vallon-Christersson, Martin Malmberg, Henrik Lindman, Anna Ehinger, Lao H. Saal & Åke Borg, 2018 Jan 17, In : British Journal of Surgery. 105, 2, p. e158–e168Research output: Contribution to journal › Article
- 2017
Myoepithelium assessment with p63 immunostaining in formalinfixed paraffin-embedded breast cancer tissue pre-treated with RNA-later
Anna Ehinger, Inger Remse, Kristina Lövgren, Cecilia Hegardt, Jari Häkkinen, Lao Saal, Johan Vallon-Christersson & Åke Borg, 2017 Sep 2, In : Virchows Archiv. 471, Supplement 1, p. 299 1 p., E-PS-02-027.Research output: Contribution to journal › Published meeting abstract
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Structure–Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi-synthetic Derivatives
Björn Borgström, Xiaoli Huang, Cecilia Hegardt, Stina Oredsson & Daniel Strand, 2017 Feb 10, In : Chemistry - A European Journal. 23, 9, p. 2077-2083 7 p.Research output: Contribution to journal › Article
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Abstract P1-07-17: The SCAN-B study: 5-year summary of a large-scale population-based prospective breast cancer translational genomics platform covering a wide geography of Sweden (NCT02306096)
Lao Saal, Cecilia Hegardt, Johan Vallon-Christersson, Jari Häkkinen, Anna Ehinger, Jonas Manjer, Christer Larsson, Niklas Loman, Lisa Rydén, Martin Malmberg & Åke Borg, 2017 Feb, In : Cancer Research. 77, 4 SupplResearch output: Contribution to journal › Published meeting abstract
- 2016
Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic
C Winter, M P Nilsson, E Olsson, A M George, Y Chen, A Kvist, T Törngren, J Vallon-Christersson, C Hegardt, J Häkkinen, G Jönsson, D Grabau, M Malmberg, U Kristoffersson, M Rehn, S K Gruvberger-Saal, C Larsson, Å Borg, N Loman & L H Saal, 2016 Aug, In : Annals of Oncology. 27, 8, p. 1532-8 7 p.Research output: Contribution to journal › Article
Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs.
Xiaoli Huang, Björn Borgström, Sebastian Kempengren, Lo Persson, Cecilia Hegardt, Daniel Strand & Stina Oredsson, 2016, In : BMC Cancer. 16, 1, 145.Research output: Contribution to journal › Article
- 2015
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Stem cell biomarker ALDH1A1 in breast cancer shows an association with prognosis and clinicopathological variables that is highly cut-off dependent.
Martin Sjöström, Linda Werner Hartman, Gabriella Honeth, Dorthe Grabau, Per Malmström, Cecilia Hegardt, Mårten Fernö & Emma Niméus, 2015, In : Journal of Clinical Pathology. 68, 12, p. 1012-1019Research output: Contribution to journal › Article
The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine.
Lao Saal, Johan Vallon-Christersson, Jari Häkkinen, Cecilia Hegardt, Dorthe Grabau, Christof Winter, Christian Brueffer, Man-Hung Eric Tang, Christel Reuterswärd, Ralph Schulz, Anna K Karlsson, Anna Ehinger, Janne Malina, Jonas Manjer, Martin Malmberg, Christer Larsson, Lisa Rydén, Niklas Loman & Åke Borg, 2015, In : Genome Medicine. 7, 1, 20.Research output: Contribution to journal › Article
- 2014
Semisynthesis of SY-1 for Investigation of Breast Cancer Stem Cell Selectivity of C-Ring-Modified Salinomycin Analogues.
Xiaoli Huang, Björn Borgström, Linda Månsson, Lo Persson, Stina Oredsson, Cecilia Hegardt & Daniel Strand, 2014, In : ACS Chemical Biology. 9, 7, p. 1587-1594Research output: Contribution to journal › Article
- 2013
Synthetic modification of salinomycin: selective O-acylation and biological evaluation
Björn Borgström, Xiaoli Huang, Martin Posta, Cecilia Hegardt, Stina Oredsson & Daniel Strand, 2013, In : Chemical Communications. 49, 85, p. 9944-9946 3 p.Research output: Contribution to journal › Article
- 2012
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Characterisation of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumours.
Karolina Holm, Johan Staaf, Göran B Jönsson, Johan Vallon-Christersson, Haukur Gunnarsson, Adalgeir Arason, Linda Magnusson, Rosa B Barkardottir, Cecilia Hegardt, Markus Ringnér & Åke Borg, 2012, In : Breast Cancer Research and Treatment. 133, 2, p. 583-594Research output: Contribution to journal › Article
Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes.
Karolina Holm, Dorthe Grabau, Kristina Lövgren, Steina Aradottir, Sofia Gruvberger, Jillian Howlin, Lao Saal, Stephen P Ethier, Pär-Ola Bendahl, Olle Stål, Per Malmström, Mårten Fernö, Lisa Rydén, Cecilia Hegardt, Åke Borg & Markus Ringnér, 2012, In : Molecular Oncology. 6, 5, p. 494-506Research output: Contribution to journal › Article
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The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer.
Göran B Jönsson, Johan Staaf, Johan Vallon-Christersson, Markus Ringnér, Sofia Gruvberger, Lao Saal, Karolina Holm, Cecilia Hegardt, Adalgeir Arason, Rainer Fagerholm, Camilla Olsson, Dorthe Grabau, Ellinor Johnsson, Kristina Lövgren, Linda Magnusson, Paivi Heikkilä, Bjarni A Agnarsson, Oskar Th Johannsson, Per Malmström, Mårten Fernö & 5 others, , 2012, In : Cancer Research. 72, 16, p. 4028-4036Research output: Contribution to journal › Article
- 2011
CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers.
Eleonor Olsson, Gabriella Honeth, Pär-Ola Bendahl, Lao Saal, Sofia Gruvberger, Markus Ringnér, Johan Vallon-Christersson, Göran B Jönsson, Karolina Holm, Kristina Lövgren, Mårten Fernö, Dorthe Grabau, Åke Borg & Cecilia Hegardt, 2011, In : BMC Cancer. 11, 418.Research output: Contribution to journal › Article
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The antiproliferative effect of dietary fibre phenolic compounds ferulic acid and p-coumaric acid on the cell cycle in Caco-2 cells
Birgit Janicke, Cecilia Hegardt, Morten Krogh, Gunilla Önning, Björn Åkesson, Helena Cirenajwis & Stina Oredsson, 2011, In : Nutrition and Cancer. 63, p. 611-622 12 p.Research output: Contribution to journal › Article
- 2010
Genomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristics
Göran B Jönsson, Johan Staaf, Johan Vallon-Christersson, Markus Ringnér, Karolina Holm, Cecilia Hegardt, Haukur Gunnarsson, Rainer Fagerholm, Carina Forsare, Bjarni A. Agnarsson, Outi Kilpivaara, Lena Luts, Paivi Heikkila, Kristiina Aittomaki, Carl Blomqvist, Niklas Loman, Per Malmström, Håkan Olsson, Oskar Th Johannsson, Adalgeir Arason & 3 others, , 2010, In : Breast Cancer Research. 12, 3, R42.Research output: Contribution to journal › Article
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Identification of Subtypes in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome.
Johan Staaf, Markus Ringnér, Johan Vallon-Christersson, Göran B Jönsson, Pär-Ola Bendahl, Karolina Holm, Adalgeir Arason, Haukur Gunnarsson, Cecilia Hegardt, Bjarni A Agnarsson, Lena Luts, Dorthe Grabau, Mårten Fernö, Per Malmström, Oskar Th Johannsson, Niklas Loman, Rosa B Barkardottir & Åke Borg, 2010, In : Journal of Clinical Oncology. 28, 11, p. 1813-1820Research output: Contribution to journal › Article
Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Karolina Holm, Cecilia Hegardt, Johan Staaf, Johan Vallon-Christersson, Göran B Jönsson, Håkan Olsson, Åke Borg & Markus Ringnér, 2010, In : Breast Cancer Research. 12, 3, R36.Research output: Contribution to journal › Article
Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.
Karin Rennstam, Nicole McMichael, Pontus Berglund, Gabriella Honeth, Cecilia Hegardt, Lisa Rydén, Lena Luts, Pär-Ola Bendahl & Ingrid Hedenfalk, 2010, In : Breast Cancer Research and Treatment. 122, p. 315-324Research output: Contribution to journal › Article
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Reduction of the putative CD44+CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047.
Helena Cirenajwis, Sandra Smiljanic, Gabriella Honeth, Cecilia Hegardt, Laurence J Marton & Stina Oredsson, 2010, In : Anti-Cancer Drugs. 21, 10, p. 897-906Research output: Contribution to journal › Article
- 2008
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Different cell cycle kinetic effects of N1,N11-diethylnorspermine-induced polyamine depletion in four human breast cancer cell lines.
Louise Myhre, Kersti Alm, Cecilia Hegardt, Johan Staaf, Göran B Jönsson, Sara Larsson & Stina Oredsson, 2008, In : Anti-Cancer Drugs. 19, 4, p. 359-368Research output: Contribution to journal › Article
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Effect of polyamine deficiency on proteins involved in Okazaki fragment maturation.
Veronica Johansson, Maria Falck Miniotis, Cecilia Hegardt, Göran B Jönsson, Johan Staaf, Pia Berntsson, Stina Oredsson & Kersti Alm, 2008, In : Cell Biology International. 32, p. 1467-1477Research output: Contribution to journal › Article
The CD44(+)/CD24(-) phenotype is enriched in basal-like breast tumors
Gabriella Honeth, Pär-Ola Bendahl, Markus Ringnér, Lao Saal, Sofia Gruvberger, Kristina Lövgren, Dorthe Grabau, Mårten Fernö, Åke Borg & Cecilia Hegardt, 2008, In : Breast Cancer Research. 10, 3, R53.Research output: Contribution to journal › Article
- 2007
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