Charlotte Ling

Professor
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  1. 2019
  2. Liver DNA methylation of FADS2 associates with FADS2 genotypex 06 Biological Sciences 0604 Genetics

    Walle, P., Männistö, V., De Mello, V. D., Vaittinen, M., Alexander Perfilyev, Hanhineva, K., Charlotte Ling & Pihlajamäki, J., 2019 Jan 17, In : Clinical Epigenetics. 11, 1, 10.

    Research output: Contribution to journalArticle

  3. Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

    Cajsa Davegårdh, Hall Wedin, E., Broholm, C., Henriksen, T. I., Pedersen, M., Pedersen, B. K., Scheele, C. & Charlotte Ling, 2019 Jan 15, In : Stem Cell Research and Therapy. 10, 1, 26.

    Research output: Contribution to journalArticle

  4. Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

    Kluth, O., Stadion, M., Gottmann, P., Aga, H., Jähnert, M., Scherneck, S., Vogel, H., Krus, U., Seelig, A., Charlotte Ling, Gerdes, J. & Schürmann, A., 2019, In : Cell Reports. 26, 11, p. 3027-3036.e3

    Research output: Contribution to journalArticle

  5. Epigenetics in Human Obesity and Type 2 Diabetes

    Charlotte Ling & Tina Rönn, 2019, In : Cell Metabolism. 29, 5, p. 1028-1044 17 p.

    Research output: Contribution to journalReview article

  6. 2018
  7. A Single Bout of Electroacupuncture Remodels Epigenetic and Transcriptional Changes in Adipose Tissue in Polycystic Ovary Syndrome

    Kokosar, M., Benrick, A., Alexander Perfilyev, Emma Nilsson, Källman, T., Ohlsson, C., Charlotte Ling & Stener-Victorin, E., 2018 Dec 1, In : Scientific Reports. 8, 1, 1878.

    Research output: Contribution to journalArticle

  8. Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

    Line Hjort, Martino, D., Grunnet, L. G., Naeem, H., Maksimovic, J., Olsson, A. H., Zhang, C., Charlotte Ling, Olsen, S. F., Saffery, R. & Allan Arthur Vaag, 2018 Sep 6, In : JCI Insight. 3, 17, e122572.

    Research output: Contribution to journalArticle

  9. Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

    Backe, M. B., Andersson, J. L., Karl Bacos, Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, M., Dahlby, T., Bysani, M., Kristensen, L. H., Charlotte Ling, Olsen, L. & Mandrup-Poulsen, T., 2018, In : Molecular and Cellular Endocrinology. 460, p. 47-56

    Research output: Contribution to journalArticle

  10. 2017
  11. Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver

    Sonia García-Calzón, Alexander Perfilyev, Männistö, V., de Mello, V., Emma A Nilsson, Pihlajamäki, J. & Charlotte Ling, 2017 Sep 21, In : Clinical Epigenetics. 9, 1, p. 1-9 102.

    Research output: Contribution to journalArticle

  12. 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner

    Hjort, L., Jørgensen, S. W., Gillberg, L., Hall, E., Brøns, C., Frystyk, J., Allan A. Vaag & Charlotte Ling, 2017 Apr 21, In : Clinical Epigenetics. 9, 1, 40.

    Research output: Contribution to journalArticle

  13. Fetal hyperglycemia changes human preadipocyte function in adult life

    Hansen, N. S., Strasko, K. S., Hjort, L., Kelstrup, L., Houshmand-ØRegaard, A., Schrölkamp, M., Schultz, H. S., Scheele, C., Pedersen, B. K., Charlotte Ling, Clausen, T. D., Damm, P., Allan Vaag & Broholm, C., 2017 Apr 1, In : Journal of Clinical Endocrinology and Metabolism. 102, 4, p. 1141-1150 10 p.

    Research output: Contribution to journalArticle

  14. Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: A randomized controlled trial

    Alexander Perfilyev, Dahlman, I., Gillberg, L., Rosqvist, F., Iggman, D., Petr Volkov, Emma Nilsson, Risérus, U. & Charlotte Ling, 2017 Apr 1, In : American Journal of Clinical Nutrition. 105, 4, p. 991-1000 10 p.

    Research output: Contribution to journalArticle

  15. Abnormal epigenetic changes during differentiation of human skeletal muscle stem cells from obese subjects

    Cajsa Davegårdh, Broholm, C., Alexander Perfilyev, Henriksen, T., Sonia García-Calzón, Peijs, L., Hansen, N. S., Petr Volkov, Kjøbsted, R., Wojtaszewski, J. F. P., Pedersen, M., Pedersen, B. K., Ballak, D. B., Dinarello, C. A., Heinhuis, B., Joosten, L. A. B., Emma Nilsson, Allan Vaag, Scheele, C. & Charlotte Ling, 2017 Feb 22, In : BMC Medicine. 15, 1, p. 1-27 27 p., 39.

    Research output: Contribution to journalArticle

  16. Epigenetic alterations in blood mirror age-associated DNA methylation and gene expression changes in human liver

    Bysani, M., Alexander Perfilyev, de Mello, V., Tina Rönn, Nilsson, E., Pihlajamäki, J. & Charlotte Ling, 2017 Feb 1, In : Epigenomics. 9, 2, p. 105-122 18 p.

    Research output: Contribution to journalArticle

  17. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

    Keller, M., Hopp, L., Liu, X., Wohland, T., Rohde, K., Cancello, R., Klös, M., Bacos, K., Kern, M., Eichelmann, F., Dietrich, A., Schön, M. R., Gärtner, D., Lohmann, T., Dreßler, M., Stumvoll, M., Kovacs, P., DiBlasio, A. M., Ling, C., Binder, H. & 2 othersBlüher, M. & Böttcher, Y., 2017 Jan 1, In : Molecular Metabolism. 6, 1, p. 86-100 15 p.

    Research output: Contribution to journalArticle

  18. Hepatic DPP4 DNA methylation associates with fatty liver

    Baumeier, C., Saussenthaler, S., Kammel, A., Jähnert, M., Schlüter, L., Hesse, D., Canouil, M., Lobbens, S., Caiazzo, R., Raverdy, V., Pattou, F., Nilsson, E., Pihlajamäki, J., Charlotte Ling, Froguel, P., Schürmann, A. & Schwenk, R. W., 2017 Jan 1, In : Diabetes. 66, 1, p. 25-35 11 p.

    Research output: Contribution to journalArticle

  19. HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

    Daneshpajooh, M., Karl Bacos, Bysani, M., Bagge, A., Ottosson Laakso, E., Petter Vikman, Lena Eliasson, Hindrik Mulder & Charlotte Ling, 2017 Jan, In : Diabetologia. 60, 1, p. 116–125

    Research output: Contribution to journalArticle

  20. Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action

    de Mello, V., Matte, A., Alexander Perfilyev, Männistö, V., Tina Rönn, Nilsson, E., Käkelä, P., Charlotte Ling & Pihlajamäki, J., 2017, In : Epigenetics. 12, 4, p. 287-295 9 p.

    Research output: Contribution to journalArticle

  21. 2016
  22. Human adipogenesis is associated with genome-wide DNA methylation and gene-expression changes

    Broholm, C., Olsson, A. H., Alexander Perfilyev, Gillberg, L., Hansen, N. S., Ashfaq Ali, Mortensen, B., Charlotte Ling & Allan Vaag, 2016 Dec 1, In : Epigenomics. 8, 12, p. 1601-1617 17 p.

    Research output: Contribution to journalArticle

  23. Epigenetic programming of adipose-derived stem cells in low birthweight individuals

    Broholm, C., Olsson, A. H., Alexander Perfilyev, Hansen, N. S., Schrölkamp, M., Strasko, K. S., Scheele, C., Ribel-Madsen, R., Mortensen, B., Jørgensen, S. W., Charlotte Ling & Vaag, A., 2016 Dec, In : Diabetologia. 59, 12, p. 2664–2673 10 p.

    Research output: Contribution to journalArticle

  24. Epigenetic markers to further understand insulin resistance

    Charlotte Ling & Tina Rönn, 2016 Nov 1, In : Diabetologia. 59, 11, p. 2295-2297

    Research output: Contribution to journalDebate/Note/Editorial

  25. DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk

    Dayeh, T., Tuomi, T., Almgren, P., Alexander Perfilyev, Jansson, P. A., de Mello, V. D., Pihlajamäki, J., Allan Vaag, Leif Groop, Nilsson, E. & Charlotte Ling, 2016 Jul 2, In : Epigenetics. 11, 7, p. 482-488 7 p.

    Research output: Contribution to journalArticle

  26. A genome-wide mQTL analysis in human adipose tissue identifies genetic variants associated with DNA methylation, gene expression and metabolic traits

    Petr Volkov, Olsson, A. H., Gillberg, L., Jørgensen, S. W., Brøns, C., Karl Fredrik Eriksson, Leif Groop, Jansson, P. A., Nilsson, E., Tina Rönn, Allan Vaag & Charlotte Ling, 2016 Jun 1, In : PLoS ONE. 11, 6, e0157776.

    Research output: Contribution to journalArticle

  27. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes

    Peiris, H., Duffield, M. D., Fadista, J., Jessup, C. F., Kashmir, V., Genders, A. J., McGee, S. L., Martin, A. M., Saiedi, M., Morton, N., Carter, R., Cousin, M. A., Kokotos, A. C., Oskolkov, N., Volkov, P., Hough, T. A., Fisher, E. M. C., Tybulewicz, V. L. J., Busciglio, J., Coskun, P. E. & 12 othersBecker, A., Belichenko, P. V., Mobley, W. C., Ryan, M. T., Chan, J. Y., Laybutt, D. R., Coates, P. T., Yang, S., Charlotte Ling, Leif Groop, Pritchard, M. A. & Keating, D. J., 2016 May 1, In : PLoS Genetics. 12, 5, e1006033.

    Research output: Contribution to journalArticle

  28. Developmental programming: State-of-the-science and future directions: Summary from a Pennington Biomedical symposium

    Sutton, E. F., Gilmore, L. A., Dunger, D. B., Heijmans, B. T., Hivert, M-F., Charlotte Ling, Martinez, J. A., Ozanne, S. E., Simmons, R. A., Szyf, M., Waterland, R. A., Redman, L. M. & Ravussin, E., 2016 May, In : Obesity. 24, 5, p. 1018–1026

    Research output: Contribution to journalReview article

  29. Epigenetics in type 2 diabetes

    Charlotte Ling & Pasquali, L., 2016 Jan 1, The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. Springer International Publishing, p. 241-258 18 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  30. Adipose tissue transcriptomics and epigenomics in low birthweight men and controls: role of high-fat overfeeding.

    Gillberg, L., Alexander Perfilyev, Brøns, C., Thomasen, M., Grunnet, L. G., Petr Volkov, Rosqvist, F., Iggman, D., Dahlman, I., Risérus, U., Tina Rönn, Emma A Nilsson, Vaag, A. & Charlotte Ling, 2016, In : Diabetologia. 59, 4, p. 799-812

    Research output: Contribution to journalArticle

  31. Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

    Karl Bacos, Gillberg, L., Petr Volkov, Olsson, A. H., Hansen, T., Pedersen, O., Gjesing, A. P., Eiberg, H., Tuomi, T., Almgren, P., Leif Groop, Lena Eliasson, Allan Vaag, Dayeh, T. & Charlotte Ling, 2016, In : Nature Communications. 7, 11089.

    Research output: Contribution to journalArticle

  32. Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome

    Kokosar, M., Benrick, A., Alexander Perfilyev, Fornes, R., Emma A Nilsson, Maliqueo, M., Behre, C. J., Sazonova, A., Ohlsson, C., Charlotte Ling & Stener-Victorin, E., 2016, In : Scientific Reports. 6, 22883.

    Research output: Contribution to journalArticle

  33. NIH working group report-using genomic information to guide weight management: From universal to precision treatment.

    Bray, M. S., Loos, R. J. F., McCaffery, J. M., Charlotte Ling, Paul Franks, Weinstock, G. M., Snyder, M. P., Vassy, J. L. & Agurs-Collins, T., 2016, In : Obesity. 24, 1, p. 14-22

    Research output: Contribution to journalReview article

  34. Risk för typ 2-diabetes kunde förutspås med epigenetik

    Karl Bacos & Charlotte Ling, 2016, In : Läkartidningen. 113, 17

    Research output: Contribution to journalArticle

  35. 2015
  36. Genome-Wide DNA and Histone Modification Studies in Metabolic Disease

    Charlotte Ling & Tina Rönn, 2015 Oct 28, Epigenomics in Health and Disease. Elsevier Inc., p. 255-270 16 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapter

  37. DNA methylation as a diagnostic and therapeutic target in the battle against Type 2 diabetes.

    Tina Rönn & Charlotte Ling, 2015, In : Epigenomics. 7, 3, p. 451-460

    Research output: Contribution to journalReview article

  38. Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels.

    Emma A Nilsson, Matte, A., Alexander Perfilyev, de Mello, V. D., Käkelä, P., Pihlajamäki, J. & Charlotte Ling, 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 11, p. E1491-E1501

    Research output: Contribution to journalArticle

  39. Helsinki alert of biodiversity and health

    von Hertzen, L., Beutler, B., Bienenstock, J., Blaser, M., Cani, P. D., Eriksson, J., Farkkila, M., Haahtela, T., Hanski, I., Jenmalm, M. C., Kere, J., Knip, M., Kontula, K., Koskenvuo, M., Ling, C., Mandrup-Poulsen, T., von Mutius, E., Makela, M. J., Paunio, T., Pershagen, G. & 6 othersRenz, H., Rook, G., Saarela, M., Vaarala, O., Veldhoen, M. & de Vos, W. M., 2015, In : Annals of Medicine. 47, 3, p. 218-225

    Research output: Contribution to journalReview article

  40. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood.

    Tina Rönn, Petr Volkov, Gillberg, L., Kokosar, M., Alexander Perfilyev, Jacobsen, A. L., Jørgensen, S. W., Brøns, C., Jansson, P-A., Karl-Fredrik Eriksson, Pedersen, O., Hansen, T., Leif Groop, Stener-Victorin, E., Allan Vaag, Emma A Nilsson & Charlotte Ling, 2015, In : Human Molecular Genetics. 24, 13, p. 3792-3813

    Research output: Contribution to journalArticle

  41. Less pronounced response to exercise in healthy relatives to type 2 diabetics compared to controls.

    Carl Ekman, Targ Elgzyri, Ström, K., Almgren, P., Parikh, H., Dekker Nitert, M., Tina Rönn, Koivula, F., Charlotte Ling, Åsa Tornberg, Per Wollmer, Karl-Fredrik Eriksson, Leif Groop & Ola Hansson, 2015, In : Journal of Applied Physiology. 119, 9, p. 953-960

    Research output: Contribution to journalArticle

  42. The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

    Dahlman, I., Sinha, I., Gao, H., Brodin, D., Thorell, A., Rydén, M., Andersson, D. P., Henriksson, J., Alexander Perfilyev, Charlotte Ling, Dahlman-Wright, K. & Arner, P., 2015, In : International Journal of Obesity. 39, 6, p. 910-919

    Research output: Contribution to journalArticle

  43. The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes.

    Gillberg, L. & Charlotte Ling, 2015, In : Frontiers in Endocrinology. 6, 43.

    Research output: Contribution to journalReview article

  44. 2014
  45. A Central Role for GRB10 in Regulation of Islet Function in Man.

    Prokopenko, I., Poon, W., Mägi, R., Prasad, R., Salehi, S. A., Almgren, P., Osmark, P., Bouatia-Naji, N., Wierup, N., Fall, T., Stančáková, A., Barker, A., Lagou, V., Osmond, C., Xie, W., Lahti, J., Jackson, A. U., Cheng, Y-C., Liu, J., O'Connell, J. R. & 44 othersBlomstedt, P. A., Fadista, J., Alkayyali, S., Dayeh, T., Emma Ahlqvist, Taneera, J., Lecoeur, C., Kumar, A., Ola Hansson, Karin B Hansson, F Voight, B., Kang, H. M., Levy-Marchal, C., Vatin, V., Palotie, A., Syvänen, A-C., Mari, A., Weedon, M. N., Loos, R. J. F., Ong, K. K., Peter Nilsson, Isomaa, B., Tuomi, T., Wareham, N. J., Stumvoll, M., Widen, E., Lakka, T. A., Langenberg, C., Tönjes, A., Rauramaa, R., Kuusisto, J., Frayling, T. M., Froguel, P., Walker, M., Eriksson, J. G., Charlotte Ling, Kovacs, P., Ingelsson, E., McCarthy, M. I., Shuldiner, A. R., Silver, K. D., Laakso, M., Leif Groop & Valeriya Lyssenko, 2014, In : PLoS Genetics. 10, 4, e1004235.

    Research output: Contribution to journalArticle

  46. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes.

    Emma A Nilsson, Jansson, P. A., Alexander Perfilyev, Petr Volkov, Pedersen, M., Svensson, M. K., Poulsen, P., Ribel-Madsen, R., Pedersen, N. L., Almgren, P., Fadista, J., Tina Rönn, Klarlund-Pedersen, B., Scheele, C., Allan Vaag & Charlotte Ling, 2014, In : Diabetes. 63, 9, p. 2962-2976

    Research output: Contribution to journalArticle

  47. Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets.

    Hall, E., Petr Volkov, Dayeh, T., Karl Bacos, Tina Rönn, Dekker Nitert, M. & Charlotte Ling, 2014, In : BMC Medicine. 12, 1, 103.

    Research output: Contribution to journalArticle

  48. Epigenetic adaptation to regular exercise in humans.

    Charlotte Ling & Tina Rönn, 2014, In : Drug Discovery Today. 19, 7, p. 1015-1018

    Research output: Contribution to journalReview article

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