Christian Krintel

Associate Researcher

Research areas and keywords

Keywords

  • Structural biology, Drug design, Protein Crystrallography, Enzyme Design, Lipases, Biophysics

Research

Structural biology and medical perspectives of human lipases.

Lipases are enzymes that can either hydrolyze or form the esterbonds which links fatty acids to glycerol molecules in lipids. There are numerous lipases present in humans and they play important roles our biology such as the mobilization of the energy we store in fat or the synthesis of complex compounds in our brain. Therefore knowledge of the structural biology and biochemistry of our lipases is important for the understanding of many diseases as well as for the development of drugs against them.

Currently we are investigating a variety of human lipases including:

Monoglyceride lipase (MAGL), bile salt stimulated lipase (BSSL), adipose triglyceride lipase (ATGL), lysosomal acid lipase, neutral cholesterol ester hydrolase and the Sn1 specific diglyceride lipases (DAGL’s).

Recent research outputs

Midtgaard, S. R., Darwish, T. A., Pedersen, M. C., Huda, P., Larsen, A. H., Jensen, G. V., Kynde, S. A. R., Skar-Gislinge, N., Nielsen, A. J. Z., Olesen, C., Blaise, M., Dorosz, J. J., Thorsen, T. S., Venskutonytė, R., Krintel, C., Møller, J. V., Frielinghaus, H., Gilbert, E. P., Martel, A., Kastrup, J. S. & 3 othersJensen, P. E., Nissen, P. & Arleth, L., 2017 Nov 27, In : The FEBS Journal.

Research output: Contribution to journalArticle

Söndergaard Hansen, J., Christian Krintel, Hernebring, M., Haataja, T. J. K., Sofia de Marè, Sebastian Wasserstrom, Kosinska-Eriksson, U., Palmgren, M., Cecilia Holm, Karin G. Stenkula, Jones, H. A. & Karin Lindkvist-Petersson, 2016 Dec 1, In : Metabolism, Clinical and Experimental. 65, 12, p. 1731-1742 12 p.

Research output: Contribution to journalArticle

Christian Krintel, Francotte, P., Pickering, D. S., Juknaite, L., Pøhlsgaard, J., Olsen, L., Frydenvang, K., Goffin, E., Pirotte, B. & Kastrup, J. S., 2016, In : Biophysical Journal. 110, 11, p. 2397-2406

Research output: Contribution to journalArticle

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