Claes Wollheim

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  1. 2011
  2. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets.

    Beatrice Yang, Dayeh, T., Kirkpatrick, C. L., Taneera, J., Kumar, R., Leif Groop, Claes Wollheim, Dekker Nitert, M. & Charlotte Ling, 2011, In : Diabetologia. Dec, p. 360-367

    Research output: Contribution to journalArticle

  3. 2012
  4. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.

    Taneera, J., Lang, S., Sharma, A., Fadista, J., Zhou, Y., Ahlqvist, E., Jonsson, A., Lyssenko, V., Vikman, P., Hansson, O., Parikh, H., Korsgren, O., Soni, A., Krus, U., Zhang, E., Jing, X., Esguerra, J., Wollheim, C., Salehi, S. A., Rosengren, A. & 2 othersErik Renström & Leif Groop, 2012, In : Cell Metabolism. 16, 1, p. 122-134

    Research output: Contribution to journalArticle

  5. Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes.

    Beatrice Yang, Dayeh, T., Petr Volkov, Kirkpatrick, C. L., Malmgren, S., Jing, X., Erik Renström, Claes Wollheim, Dekker Nitert, M. & Charlotte Ling, 2012, In : Molecular Endocrinology. 26, 7, p. 1203-1212

    Research output: Contribution to journalArticle

  6. Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.

    Mahdi, T., Hänzelmann, S., Salehi, S. A., Jabar Muhammed, S., Reinbothe, T., Tang, Y., Axelsson, A., Zhou, Y., Jing, X., Almgren, P., Krus, U., Taneera, J., Blom, A., Lyssenko, V., Esguerra, J., Hansson, O., Eliasson, L., Derry, J., Zhang, E., Wollheim, C. & 3 othersLeif Groop, Erik Renström & Anders Rosengren, 2012, In : Cell Metabolism. 16, 5, p. 625-633

    Research output: Contribution to journalArticle

  7. 2013
  8. DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets.

    Hall, E., Dayeh, T., Kirkpatrick, C. L., Claes Wollheim, Dekker Nitert, M. & Charlotte Ling, 2013, In : BMC Medical Genetics. 14, Jul,23, 76.

    Research output: Contribution to journalArticle

  9. Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release

    Peter Spégel, Sharoyko, V., Göhring, I., Danielsson, A., Malmgren, S., Nagorny, C., Andersson, L., Köck, T., Sharp, G. W. G., Straub, S. G., Claes Wollheim & Hindrik Mulder, 2013, In : Biochemical Journal. 450, p. 595-605

    Research output: Contribution to journalArticle

  10. 2014
  11. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.

    Fadista, J., Vikman, P., Ottosson Laakso, E., Mollet, I., Esguerra, J., Taneera, J., Storm, P., Osmark, P., Ladenvall, C., Prasad, R., Hansson, K. B., Finotello, F., Uvebrant, K., Ofori, J., Di Camillo, B., Krus, U., Cilio, C., Hansson, O., Eliasson, L., Rosengren, A. & 3 othersErik Renström, Claes Wollheim & Leif Groop, 2014, In : Proceedings of the National Academy of Sciences. 111, 38, p. 13924-13929

    Research output: Contribution to journalArticle

  12. TCF7L2 is a master regulator of insulin production and processing.

    Zhou, Y., Park, S-Y., Su, J., Bailey, K., Ottosson Laakso, E., Liliya Shcherbina, Nikolay Oskolkov, Enming Zhang, Thevenin, T., Fadista, J., Bennet, H., Petter Vikman, Nils Wierup, Malin Fex, Rung, J., Claes Wollheim, Nobrega, M., Erik Renström, Leif Groop & Ola Hansson, 2014, In : Human Molecular Genetics. 23, 24, p. 6419-6431

    Research output: Contribution to journalArticle

  13. 2015
  14. Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.

    Taneera, J., Fadista, J., Emma Ahlqvist, Grubich Atac, D., Ottosson Laakso, E., Claes Wollheim & Leif Groop, 2015, In : Human Molecular Genetics. 24, 7, p. 1945-1955

    Research output: Contribution to journalArticle

  15. Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion

    Stamenkovic, J., Andersson, L., Adriaenssens, A. E., Bagge, A., Sharoyko, V., Gribble, F., Reimann, F., Claes Wollheim, Hindrik Mulder & Peter Spégel, 2015, In : Biochemical Journal. 468, p. 49-63

    Research output: Contribution to journalArticle

  16. Thrombin stimulates insulin secretion via protease-activated receptor-3.

    Hänzelmann, S., Wang, J., Güney, E., Tang, Y., Enming Zhang, Axelsson, A., Nenonen, H., S Albert Salehi, Claes Wollheim, Eva Zetterberg, Erik Berntorp, Costa, I. G., Castelo, R. & Anders Rosengren, 2015, In : Islets. 7, 4, p. e1118195

    Research output: Contribution to journalArticle

  17. 2016
  18. Transcriptional Regulation of X-Box-Binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4α) is Vital to Beta-Cell Function.

    Moore, B. D., Jin, R. U., Lo, H., Jung, M., Wang, H., Battle, M. A., Claes Wollheim, Urano, F. & Mills, J. C., 2016, In : Journal of Biological Chemistry. 291, 12, p. 6146-6157

    Research output: Contribution to journalArticle

  19. CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

    Abels, M., Riva, M., Bennet, H., Ahlqvist, E., Dyachok, O., Nagaraj, V., Shcherbina, L., Fred, R. G., Poon, W., Sörhede-Winzell, M., Fadista, J., Lindqvist, A., Kask, L., Sathanoori, R., Dekker-Nitert, M., Kuhar, M. J., Ahrén, B., Wollheim, C. B., Hansson, O., Tengholm, A. & 5 othersMalin Fex, Erik Renström, Leif Groop, Valeriya Lyssenko & Nils Wierup, 2016 Jun 23, In : Diabetologia. 59, 9, p. 1928–1937 10 p.

    Research output: Contribution to journalArticle

  20. Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

    Prasad, R. B., Lessmark, A., Almgren, P., Kovacs, G., Hansson, O., Oskolkov, N., Vitai, M., Ladenvall, C., Kovacs, P., Fadista, J., Lachmann, M., Zhou, Y., Sonestedt, E., Poon, W., Wollheim, C. B., Orho-Melander, M., Stumvoll, M., Tuomi, T., Pääbo, S., Koranyi, L. & 1 othersLeif Groop, 2016 Aug, In : Diabetologia. 59, 8, p. 1702-1713 12 p.

    Research output: Contribution to journalArticle

  21. 2017
  22. Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes

    L Shcherbina, A Edlund, J L S Esguerra, Abels, M., Zhou, Y., Ottosson-Laakso, E., C B Wollheim, O Hansson, L Eliasson & N Wierup, 2017, In : Molecular and Cellular Endocrinology. 447, p. 52-60

    Research output: Contribution to journalArticle

  23. Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes

    Axelsson, A., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M. & 9 othersJ D Johnson, C B Wollheim, Derry, J. M. J., Mecham, B., P Spégel, H Mulder, Costa, I. G., E Zhang & Rosengren, A. H., 2017 Jun 6, In : Nature Communications. 8, p. 15652

    Research output: Contribution to journalArticle

  24. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

    Axelsson, A. S., Tubbs, E., Mecham, B., Chacko, S., Nenonen, H. A., Tang, Y., Fahey, J. W., Derry, J. M. J., Claes B. Wollheim, Nils Wierup, Haymond, M. W., Friend, S. H., Hindrik Mulder & Anders H. Rosengren, 2017 Jun 14, In : Science Translational Medicine. 9, 394, 4477.

    Research output: Contribution to journalArticle

  25. 2018
  26. Silencing of the FTO gene inhibits insulin secretion: An in vitro study using GRINCH cells

    Taneera, J., Rashmi B Prasad, Dhaiban, S., Mohammed, A. K., Haataja, L., Arvan, P., Hamad, M., Leif Groop & Claes B Wollheim, 2018, In : Molecular and Cellular Endocrinology. 472, p. 10-17

    Research output: Contribution to journalArticle

  27. Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production

    Tubbs, E., Axelsson, A. S., Vial, G., Claes B. Wollheim, Rieusset, J. & Anders H. Rosengren, 2018, In : Molecular and Cellular Endocrinology. 461, p. 205-214

    Research output: Contribution to journalArticle

  28. Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase

    Andersson, L. E., Liliya Shcherbina, Al-Majdoub, M., Neelanjan Vishnu, Arroyo, C. B., Carrara, J. A., Claes B. Wollheim, Malin Fex, Hindrik Mulder, Nils Wierup & Peter Spégel, 2018 Mar 1, In : Diabetes. 67, 3, p. 372-384 13 p.

    Research output: Contribution to journalArticle

  29. 2019
  30. Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

    Enming Zhang, Israa Mohammed, Mohammed, S., Cheng Luan, Olof Asplund, Ahmed, M., Ye Yingying, Ben-Hail, D., Soni, A., Vishnu, N., Bompada Pradeep, Yang de Marinis, Leif Groop, Shoshan-Barmatz, V., Erik Renström, Claes Wollheim & S Albert Salehi, 2019 Jan 8, In : Cell Metabolism. 29, 1, p. 64-77.e6

    Research output: Contribution to journalArticle