Daniel Bexell

Researcher, Associate Professor

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Neuroblastoma, Metastasis

Research

Novel treatment against childhood cancer neuroblastoma
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. Treatment of children with high-risk neuroblastoma remains largely unsuccessful, because of metastasis and treatment resistance, and is a serious clinical problem. There is therefore an urgent need for development of novel treatment for these children. One major obstacle in translational cancer research has been the lack of predictive preclinical models that faithfully represent tumors occurring in patients. Consequently, many therapeutic approaches based on these in vivo models have failed in clinical trials. We have recently established and characterized the first neuroblastoma orthotopic patient-derived xenografts (PDXs) by implanting patient-derived tumor explants into mice. These PDXs display invasive growth, spontaneous metastasis, and recapitulate the histology, protein marker expression, and clinically important gene copy number changes of the original tumors. Our goal is to use neuroblastoma PDXs to comprehensively characterize and target neuroblastoma metastases and treatment resistance. We combine next generation sequencing, in vitro drug testingcell- and molecular biology techniques, in vivo drug testing and advanced in vivo imaging to understand and target metastatic and treatment resistant tumors. Novel strategies for inhibiting aggressive neuroblastoma while minimizing toxicity are expected to increase survival of neuroblastoma patients, for whom prognosis is currently poor.

Highlighted research outputs

Braekeveldt, N., Von Stedingk, K., Fransson, S., Martinez-Monleon, A., Lindgren, D., Axelson, H., Levander, F., Willforss, J., Hansson, K., Øra, I., Backman, T., Börjesson, A., Beckman, S., Esfandyari, J., Berbegall, A. P., Noguera, R., Karlsson, J., Koster, J., Martinsson, T., Gisselsson, D. & 2 othersSven Påhlman & Daniel Bexell, 2018, In : Cancer Research. 78, 20, p. 5958-5969 12 p.

Research output: Contribution to journalArticle

Jenny Karlsson, Anders Valind, Linda Holmquist Mengelbier, Bredin, S., Louise Cornmark, Jansson, C., Wali, A., Johan Staaf, Viklund, B., Ingrid Øra, Anna Börjesson, Backman, T., Noémie Braekeveldt, Sandstedt, B., Pal, N., Isaksson, A., Lackner, B. G., Tord Jonson, Daniel Bexell & David Gisselsson, 2018 Jul, In : Nature Genetics. 50, 7, p. 944-950

Research output: Contribution to journalArticle

Noémie Braekeveldt, Wigerup, C., Tadeo, I., Beckman, S., Caroline Sandén, Jönsson, J., Jonas S Erjefält, Berbegall, A. P., Anna Börjesson, Backman, T., Ingrid Øra, Navarro, S., Noguera, R., David Gisselsson, Sven Påhlman & Daniel Bexell, 2016, In : Cancer Letters. 375, 2, p. 384-389

Research output: Contribution to journalArticle

Holmquist Mengelbier, L., Karlsson, J., Lindgren, D., Valind, A., Lilljebjörn, H., Jansson, C., Bexell, D., Braekeveldt, N., Ameur, A., Jonson, T., Kultima, H. G., Isaksson, A., Asmundsson, J., Versteeg, R., Rissler, M., Fioretos, T., Sandstedt, B., Börjesson, A., Backman, T., Pal, N. & 3 othersIngrid Øra, Mayrhofer, M. & David Gisselsson Nord, 2015, In : Nature Communications. 6, 6125.

Research output: Contribution to journalArticle

Noémie Braekeveldt, Wigerup, C., David Gisselsson Nord, Sofie Mohlin, Merselius, M., Beckman, S., Tord Jonson, Anna Börjesson, Backman, T., Tadeo, I., Berbegall, A. P., Ingrid Øra, Navarro, S., Noguera, R., Sven Påhlman & Daniel Bexell, 2015, In : International Journal of Cancer. 136, 5, p. E252-E261

Research output: Contribution to journalArticle

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