Daniel Bexell

Associate Professor, Senior Lecturer

Research areas and keywords

UKÄ subject classification

  • Cancer and Oncology

Keywords

  • Neuroblastoma, Metastasis

Research

Novel treatment against childhood cancer neuroblastoma
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. Treatment of children with high-risk neuroblastoma remains largely unsuccessful, because of metastasis and treatment resistance, and is a serious clinical problem. There is therefore an urgent need for development of novel treatment for these children. One major obstacle in translational cancer research has been the lack of predictive preclinical models that faithfully represent tumors occurring in patients. Consequently, many therapeutic approaches based on these in vivo models have failed in clinical trials. We have recently established and characterized the first neuroblastoma orthotopic patient-derived xenografts (PDXs) by implanting patient-derived tumor explants into mice. These PDXs display invasive growth, spontaneous metastasis, and recapitulate the histology, protein marker expression, and clinically important gene copy number changes of the original tumors. Our goal is to use neuroblastoma PDXs to comprehensively characterize and target neuroblastoma metastases and treatment resistance. We combine next generation sequencing, in vitro drug testingcell- and molecular biology techniques, in vivo drug testing and advanced in vivo imaging to understand and target metastatic and treatment resistant tumors. Novel strategies for inhibiting aggressive neuroblastoma while minimizing toxicity are expected to increase survival of neuroblastoma patients, for whom prognosis is currently poor.

Highlighted research outputs

Sofie Mohlin, Karin Hansson, Katarzyna Radke, Sonia Martinez, Carmen Blanco-Apiricio, Cristian Garcia-Ruiz, Charlotte Welinder, Javanshir Esfandyari, Michael O'Neill, Joaquin Pastor, Kristoffer von Stedingk & Daniel Bexell, 2019 Aug 1, In : EMBO Molecular Medicine. 11, 8, e10058.

Research output: Contribution to journalArticle

Noémie Braekeveldt, Kristoffer Von Stedingk, Susanne Fransson, Angela Martinez-Monleon, David Lindgren, Håkan Axelson, Fredrik Levander, Jakob Willforss, Karin Hansson, Ingrid Øra, Torbjörn Backman, Anna Börjesson, Siv Beckman, Javanshir Esfandyari, Ana P. Berbegall, Rosa Noguera, Jenny Karlsson, Jan Koster, Tommy Martinsson, David Gisselsson & 2 others, Sven Påhlman & Daniel Bexell, 2018, In : Cancer Research. 78, 20, p. 5958-5969 12 p.

Research output: Contribution to journalArticle

Jenny Karlsson, Anders Valind, Linda Holmquist Mengelbier, Sofia Bredin, Louise Cornmark, Caroline Jansson, Amina Wali, Johan Staaf, Björn Viklund, Ingrid Øra, Anna Börjesson, Torbjörn Backman, Noémie Braekeveldt, Bengt Sandstedt, Niklas Pal, Anders Isaksson, Barbara Gürtl Lackner, Tord Jonson, Daniel Bexell & David Gisselsson, 2018 Jul, In : Nature Genetics. 50, 7, p. 944-950

Research output: Contribution to journalArticle

Noémie Braekeveldt, Caroline Wigerup, David Gisselsson Nord, Sofie Mohlin, My Merselius, Siv Beckman, Tord Jonson, Anna Börjesson, Torbjörn Backman, Irene Tadeo, Ana P Berbegall, Ingrid Øra, Samuel Navarro, Rosa Noguera, Sven Påhlman & Daniel Bexell, 2015, In : International Journal of Cancer. 136, 5, p. E252-E261

Research output: Contribution to journalArticle

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