Darcy Wagner

Senior Lecturer, Docent, Wallenberg Molecular Medicine Fellow, Doctor of Philosophy (PhD) in Biomedical Engineering, Bachelor of Science in Mechanical Engineering (BSME)

Research areas and keywords

UKÄ subject classification

  • Cell and Molecular Biology
  • Biomaterials Science
  • Manufacturing, Surface and Joining Technology

Keywords

  • Lung Regeneration, Tissue Engineering, Stem Cells, Biomaterials, Mechanotransduction, Hippo, Bioengineering, Ex vivo, Bioreactor

Research

Over three million people die each year and over 60 million people suffer worldwide from chronic lung diseases (CLDs). At present, there is no cure for CLDs, including chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and pulmonary fibrosis. Lung transplantation is the only option at end-stage disease and is further complicated by shortage in organs available for transplantation and low efficacy. Five-year survival rate has remained at 50% for the last decade. New options are desperately needed for these patients.

My lab focuses on understanding the role of the extracellular environment for endogenous and exogenous lung tissue regeneration in healthy and diseased lung. In particular, our work focuses on the design and use of biologic and synthetic scaffolds to bioengineer new lung tissue for transplantation. We further aim to build new models of human lung tissue to reduce animal usage, better understand how regeneration processes are deranged in CLDs, and for use as drug discovery and therapeutic screening platforms.

Highlighted research outputs

Deniz Bölükbas, Stefan Datz, Charlotte Meyer-Schwickerath, Carmela Morrone, Ali Doryab, Dorothee Gössl, Malamati Vreka, Lin Yang, Christian Argyo, Sabine van Rijt, Michael Lindner, Oliver Eickelberg, Tobias Stoeger, Otmar Schmid, Sandra Lindstedt, Georgios T Stathopoulos, Thomas Bein, Darcy Wagner & Silke Meiners, 2020 May 13, In : Advanced Therapeutics.

Research output: Contribution to journalArticle

Cassandra L. Petrou, Tyler J. D'Ovidio, Deniz Bölükbas, Sinem Tas, R. Dale Brown, Ayed Allawzi, Sandra Lindstedt Ingemansson, Eva Nozik-Grayck, Kurt R. Stenmark, Darcy Wagner & Chelsea M. Magin, 2020 Aug 21, In : Journal of Materials Chemistry B. 8, 31, p. 6814-6826

Research output: Contribution to journalArticle

Dongsheng Jiang, Donovan Correa-Gallegos, Simon Christ, Ania Stefanska, Juan Liu, Pushkar Ramesh, Vijayanand Rajendran, Martina M. De Santis, Darcy E. Wagner & Yuval Rinkevich, 2018 Apr 1, In : Nature Cell Biology. 20, 4, p. 422-431 10 p.

Research output: Contribution to journalArticle

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